05/08/2025
A new scientific bombshell: what’s happening in your mouth could shape the fate of your brain. Researchers have now linked gum disease, specifically the bacteria Porphyromonas gingivalis, to the onset and progression of Alzheimer’s. This microscopic menace doesn’t just cause bad breath or bleeding gums. Scientists have found it in the brains of Alzheimer’s patients, and in lab animals, it actually invades brain tissue, igniting the buildup of toxic amyloid beta, the same protein that destroys memory and cognition.
Even more alarming: these bacteria release harmful enzymes that show up in the brain years before any clinical signs of dementia, hinting that chronic gum infection could trigger Alzheimer’s long before symptoms appear. The discovery is so powerful, it’s shifting how experts approach the disease. A new drug, COR388 from Cortexyme, is already showing promise in blocking both the bacteria and the deadly protein tangle it creates in animal models.
With no major breakthrough in dementia treatments for over a decade, this new mouth-brain connection is a wake-up call. Good oral hygiene, brushing, flossing, and regular dental checkups, may be one of the most important (and overlooked) ways to protect your brain for years to come. Sometimes the first line of defense against memory loss starts with your toothbrush.
Source: Dominy, S.S., et al., Science Advances, 2019; mouth-brain research, new Alzheimer’s treatment developments.
