22/08/2025
The meaning of moulding.
When neoplastic cells lose their “contact inhibition” mechanism and, instead of stopping, continue to increase in volume, crushing adjacent cells.
The nuclei appear to press into and deform against their neighbors, taking on an irregular, angled shape rather than a uniform one.
Nuclear molding is observed when cells are crowded into tight, cohesive sheets or clusters, a pattern common in aggressive tumor
