Human Technopole

12/03/2026

🫀 What if we could predict heart failure long before symptoms appear?

📊 In three international studies in the European Heart Journal, our Emanuele Di Angelantonio, Head of the Health Data Science Research Centre, co-led the development of three complementary models estimating heart failure risk across the entire cardiovascular disease spectrum.

🔬 From prevention in healthy adults to prognosis in patients with established disease, these tools use large-scale data to support earlier detection, more personalised care and more sustainable healthcare systems. Research that turns data into insight for human health.

Read more 👉https://humantechnopole.it/en/news/predicting-heart-failure-before-it-strikes/

11/03/2026

🧬 What determines how long a messenger RNA molecule stays active inside a cell?

🔬 Our Ivano Legnini, Group Leader at the Genomics Research Centre, has received a €1.35M Consolidator Grant from the Fondo Italiano per la Scienza for POLARIS, a project exploring how poly(A) tails control mRNA stability and gene expression.

🧠 By combining advanced sequencing, AI and computational modelling, the project aims to uncover the molecular logic behind RNA regulation. At Human Technopole, connecting disciplines and technologies helps turn basic research into discoveries shaping the future of human health.

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Human Technopole has been awarded a €1.35 million Consolidator Grant from the Fondo Italiano per la Scienza (FIS3) to investigate how cells control the stability of messenger RNAs. The funding will support the POLARIS project, led by the Legnini Group, which aims to uncover the molecular principle...

04/03/2026

🤖 What if artificial intelligence could help biology speak more clearly about health and disease?

🔬 Our Florian Jug, Research Group Leader, leads a team developing advanced AI methods to extract the most meaningful information from complex biological data. By supporting collaborators across life sciences, his Group helps push research beyond current limits and towards more precise understanding of human health conditions.

🏗️ From hackathons to international conferences, MIND is rapidly evolving into a thriving ecosystem where researchers meet, exchange ideas and build the future together.

Watch the interview 👉

Human Technopole at MIND Milano: pushing the boundaries of life sciences with AI-driven research. Florian Jug, Research Group Leader, explains how HT combine...

25/02/2026

🔬 How does a young institute position itself among top research centres worldwide?

🌍 In this interview, our Malina Iwanski, Postdoctoral Researcher in the Molecular Cell Biology Research Centre, reflects on HT’s role as a scientific pillar within the MIND district. She highlights how fundamental research and innovation form a continuous cycle: new ideas spark technologies, technologies enable new questions, and discoveries move closer to real-world impact.

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Human Technopole: advancing world-class scientific research and collaboration. Postdoctoral researcher Malina Iwanski shares how HT is shaping the future of ...

20/02/2026

🧬 How do we push imaging beyond the diffraction limit to understand biology molecule by molecule?

🎙️ In this interview, Ralf Jungmann (MPI of Biochemistry), guest of our “HT Seminars: Connecting Discoveries” series, shares how DNA-PAINT is enabling new insights into molecular organisation and function.

🔬 The series brings leading international researchers to Human Technopole, strengthening interdisciplinary exchange across the life sciences.

👏 Thanks to our interviewers: Damian Edward Dalle Nogare (National Facility for Data Handling & Analysis) and Diya Srivastava (Jug Group, Computational Biology Research Centre), for guiding this conversation.

Watch the full interview 👉

How do we push imaging beyond the diffraction limit to understand biology molecule by molecule? In this interview, Ralf Jungmann (MPI of Biochemistry), guest...

19/02/2026

🧠 How do synapses regulate the proteins that enable learning and memory?

🔬 On 26 February 2026, we host Erin Schuman, Director at the Max Planck Institute for Brain Research, for the next “HT Seminars: Connecting Discoveries” talk. She will discuss how neurons produce and degrade proteins directly at synapses, and why this local control is essential for plasticity and brain function.

🌍 The HT Seminars series bring leading international scientists to MIND - Milan Innovation District to connect disciplines and spark exchange across genomics, structural biology, neurogenomics and health data science. By advancing basic research, we open new opportunities to understand complex biological systems and improve human health, together.

Register by 25 February 2026 👉 https://humantechnopole.it/en/training/external-training/external-seminar-series-2026/ #26-february-2026-erin-schuman

18/02/2026

🌱 Can a research campus change how we do science and how we live in a city?

🔬 In this interview, our Giovanni Maltinti, PhD student in the Gaia Pigino Group, reflects on two core values of Human Technopole and the wider MIND district: collaboration and innovation. Scientists working side by side, sharing tools and ideas, are essential to move research forward. Technologies such as cryo-electron microscopes, rare in Italy and across Europe, enable us to study life at unprecedented detail and open new paths towards discoveries that can improve life expectancy and quality of life.

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Human Technopole at MIND Milano: empowering the next generation of scientists. Giovanni Maltinti, PhD student, shares how collaboration and innovation drive ...

14/02/2026

Our Piero Carninci, Head of Genomics Research Centre (Functional Genomics Programme), was a guest on Radio3 Scienza to explore a key question in biology: what does non-coding DNA really do?

🧬 With tools like AlphaGenome, AI can analyse up to one million DNA bases at once, helping predict the impact of mutations in regions once called “junk DNA”.

🤖 A step towards connecting data, biology and discovery to advance human health.

In Italian 👉

La lingua del DNA - Radio3 Scienza - Nel 2024 con AlphaFold si era aggiudicata il Premio Nobel per la chimica. Oggi l'azienda DeepMind di Google sulle pagine di Nature ha annunciato un nuovo strumento di ricerca: AlphaGenome. Il software, con l'aiuto dell'intelligenza artificiale, sarebbe in grado d...

13/02/2026

🧬 What if looking beyond known genes could unlock new cancer treatments?

💻 🔬 Our Lorenzo Calviello, Group Leader in the Genomics and Computational Biology Research Centres, has been awarded from Fondazione AIRC per la Ricerca sul Cancro to study how novel RNAs and proteins drive colorectal cancer and how they could become new targets for immunotherapy.

The project brings together computational biology, patient-derived organoids and advanced proteomics, powered by Human Technopole’s National Facilities and international collaboration.

Lorenzo Calviello and his group of the Human Technopole’s Research Centres for Genomics and Computational Biology have been awarded a five-year My First AIRC Grant by Fondazione AIRC per la Ricerca sul Cancro. The grant provides over €99,000 for 2026, for a total of €500,000, to support a proj...

05/02/2026

🔓A new Call for Access to our National Facilities is now open, building on a 147% year-on-year growth in proposals from the Italian research community.

🔬 From genomics to imaging and data analysis, researchers gain access to advanced technologies and dedicated scientific support.

🤝 An open, merit-based model designed to connect disciplines and accelerate discovery.

Discover more and submit your proposal 👉

Human Technopole has opened a new Call for Access to its National Facilities on 1 February 2026, offering researchers from Italy the opportunity to access cutting-edge technologies and expertise across the institute’s advanced research platforms.

03/02/2026

🔬 How are thyroid hormones released at the molecular level?

🧬 Our Coscia Group uncovered how sortilin binds thyroglobulin through a flexible peptide motif, guiding it along the pathway to hormone release. Using cryo-EM, biophysics and AI-based modelling, the study reveals a mechanism that may apply to many other proteins across the body.

Published in Nature Communications.

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Human Technopole researchers have identified the molecular mechanisms by which the membrane receptor sortilin binds thyroglobulin along its pathway to the release of thyroid hormones within the thyroid gland. The results of the research were published in Nature Communications and highlight that sort...

26/01/2026

🧠 AI works best when it’s shared! The AI4Life project, co-led by our Florian Jug (Computational Biology Research Centre) and Anna Kreshuk (EMBL), earned the top score in the European Commission’s final review.

🔬 The project tackled a key challenge: making AI accessible to non-specialist researchers. Tools like the BioImage Model Zoo let scientists use powerful AI models without advanced coding skills.

The AI4Life project, co-led by Florian Jug (Computational Biology Research Centre at Human Technopole) and Anna Kreshuk (EMBL), received the highest possible score in the European Commission’s final review, recognising its scientific impact and the quality of its achievements in applying artificia...