
18/09/2025
Acute myeloid leukemia-associated mutations influence the biology of hematopoietic cells during the pre-leukemic phase, and could sustain leukemic stem cell (LSC) quiescence through modulation of dormant and active states of the LSC with a critical role for extended self-renewal in pre-leukemic hematopoietic stem cells. A new study sheds light on the cooperation of nucleophosmin 1 (NPM1) gene mutations and internal tandem duplications (ITD) of the fms-related tyrosine kinase 3 (FLT3) gene in LSC.
https://haematologica.org/article/view/11973