06/02/2026
Perspective Articles: Spleen volume reduction has long been a key endpoint in randomized controlled trials in myelofibrosis.
Find here a critical review of the limitations of relying on spleen response alone and the reason for a broader, more patient-centered approach to clinical trial design. By integrating symptoms, quality of life, biological markers, and long-term outcomes, the authors discuss how future trials can better capture meaningful clinical benefit and guide therapeutic decision-making in myelofibrosis.
https://haematologica.org/article/view/12296