Haematologica

Haematologica www.haematologica.org publishes novel findings in basic, clinical and translational hematology research. Impact Factor (JCR) 7.116 (7th of 76)

Haematologica/The Hematology Journal (pISSN: 0390-6078, eISSN: 1592-8721, NLM ID: 0417435) publishes peer-reviewed papers across all areas of experimental and clinical hematology. The journal is owned by a non-profit organization, the Ferrata Storti Foundation, and serves the scientific community strictly following the International Committee of Medical Journal Editors (ICMJE, www.icmje.org) recommendations on publication ethics policies for medical journals. Haematologica was founded in 1920 by Adolfo Ferrata

Therapeutic options for children with acquired aplastic anemia continue to evolve.A new study evaluates the safety and e...
24/03/2026

Therapeutic options for children with acquired aplastic anemia continue to evolve.
A new study evaluates the safety and efficacy of romiplostim in pediatric patients who are naïve to immunosuppressive therapy, addressing an important question about treatment strategies and early disease management in this vulnerable population.
https://haematologica.org/article/view/12189

Ovarian tissue autotransplantation in acute leukemia. Fertility preservation is an increasingly important issue for pati...
22/03/2026

Ovarian tissue autotransplantation in acute leukemia.
Fertility preservation is an increasingly important issue for patients with acute leukemia. A new study examines ovarian tissue autotransplantation as a strategy to restore fertility, addressing the complex balance between oncological safety and reproductive outcomes in leukemia survivors.
https://haematologica.org/article/view/12173

Unrelated donor selection for ALL transplantation in the PTCy era. Post-transplant cyclophosphamide (PTCy) helps to rede...
20/03/2026

Unrelated donor selection for ALL transplantation in the PTCy era.
Post-transplant cyclophosphamide (PTCy) helps to redefine donor choice in allogeneic transplantation. In this analysis from the Acute Leukemia Working Party of the European Society for Blood and Marrow Transplantation, investigators evaluate key considerations when selecting unrelated donors for patients with acute lymphoblastic leukemia, addressing a central question in contemporary transplant practice.
https://haematologica.org/article/view/12195

Can we refine outcome prediction after transplant? Donor selection remains a key challenge in allogeneic hematopoietic s...
17/03/2026

Can we refine outcome prediction after transplant? Donor selection remains a key challenge in allogeneic hematopoietic stem cell transplantation. A new study explores how integrating high-resolution killer cell immunoglobulin-like receptor (KIR) genotyping may enhance our understanding of immune interactions after transplant and improve outcome prediction. The findings raise important questions about how immunogenetic profiling could shape future transplant strategies.
https://haematologica.org/article/view/12166

Transplant-associated thrombotic microangiopathy (TMA) is a serious complication occurring after hematopoietic stem cell...
15/03/2026

Transplant-associated thrombotic microangiopathy (TMA) is a serious complication occurring after hematopoietic stem cell transplantation and is driven by endothelial damage and complement activation. A new study investigates the role of KLF4 in regulating endothelial responses under these conditions, offering new mechanistic insight into vascular injury after transplantation, and raises questions about future therapeutic strategies.
doi.org/10.3324/haematol.2025.287676

Caffeine is one of the most widely consumed psychoactive compounds worldwide, making it one of the most pervasive modula...
12/03/2026

Caffeine is one of the most widely consumed psychoactive compounds worldwide, making it one of the most pervasive modulators of systemic and cellular physiology. A new study evaluates the impact of caffeine on the quality of stored red blood cells (RBC) and post-transfusion circulatory parameters. Interestingly, this psychoactive agent negatively affects RBC transfusion quality.
https://haematologica.org/article/view/12261

The identification of patients with acute myeloid leukemia (AML) who may have resistant disease when treated with standa...
10/03/2026

The identification of patients with acute myeloid leukemia (AML) who may have resistant disease when treated with standard induction chemotherapy is still challenging: Murphy and colleagues present the first prospective, multicenter study aiming to evaluate the prognostic value of the leukemic stem cell 17-gene (LSC17) score in patients with newly diagnosed AML.
https://haematologica.org/article/view/12171

Perspective Articles: Acute leukemia of ambiguous lineage (ALAL) is a rare and high-risk leukemia lacking clear lineage ...
07/03/2026

Perspective Articles: Acute leukemia of ambiguous lineage (ALAL) is a rare and high-risk leukemia lacking clear lineage differentiation, including mixed phenotype acute leukemia and acute undifferentiated leukemia. This review discusses how recent genetic, epigenetic, and metabolic insights are reshaping the diagnosis, classification, and risk stratification, while highlighting emerging targeted therapeutic strategies and persistent clinical challenges. Despite evolving WHO and ICC frameworks, major questions remain regarding optimal therapy selection, minimal residual disease monitoring, and transplantation decisions in ALAL.
https://haematologica.org/article/view/12929

Review article: An overview of the clinical landscape and diagnostic strategies for telomere biology disorders, highligh...
04/03/2026

Review article: An overview of the clinical landscape and diagnostic strategies for telomere biology disorders, highlighting the role of telomere dysfunction in cancer development and clonal hematopoiesis, and discussing emerging therapeutic approaches. The review underscores the importance of individualized, multidisciplinary management to optimize patients’ outcomes.
https://haematologica.org/article/view/12905

Primary asciminib resistance in atypical chronic myeloid leukemia (CML): a case report. How atypical fusion transcripts ...
27/02/2026

Primary asciminib resistance in atypical chronic myeloid leukemia (CML): a case report. How atypical fusion transcripts can influence treatment response and the importance of precise molecular characterization when selecting and monitoring targeted therapies in CML.
https://haematologica.org/article/view/12947

What happens to lenalidomide-induced TP53 clonal hematopoiesis (CH) in patients with multiple myeloma after lenalidomide...
25/02/2026

What happens to lenalidomide-induced TP53 clonal hematopoiesis (CH) in patients with multiple myeloma after lenalidomide cessation? Can CH be reversible? Two clinical cases raise important questions about monitoring CH and long-term risk assessment in treated patients.
https://haematologica.org/article/view/12946

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