Regenerative Technologies Lab

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Regenerative Technologies Lab

Regenerative Technologies Laboratory is part of the BioRobotics Institute of Scuola Superiore Sant’Anna.

Our scientific research focuses on developing technologies for Regenerative Medicine and Artifical Organs. The Regenerative Technologies Lab is grounded on a strongly interdisciplinary approach and on cross-fertilization between mechatronics, materials science, biotechnologies and molecular biology, with the aim of developing new therapeutic systems at different scales.

06/11/2024

🚀 Our latest research at 🚀

👩🏼‍⚕️ Sofia presented her work at the 23rd International Symposium on Therapeutic Ultrasound in 🇹🇼

🫧 She presented a poster on "Triggered drug delivery from perfluorocarbon droplets exploiting low-intensity pulsed ultrasound at low frequencies", in the framework of the European project .

🌟 It's been an amazing opportunity to learn about the latest advancements in therapeutic ultrasound, meet people working in the field from all over the world 🌎 ...
.. and of course get to know Taipei's vibrant culture and delicious cuisine! 🧋🏯

09/08/2024

📢 PAPER ALERT 📢

In the framework of the FORGETDIABETES project, our group proposed an innovative approach to refill a fully implantable system for automatic intraperitoneal or intrathecal drug delivery 💊
The system could be refilled non-invasively through an ingestible drug-carrying capsule, which was magnetically docked 🧲

🚀 See the paper, published on Advanced Intelligent Systems: https://onlinelibrary.wiley.com/doi/full/10.1002/aisy.202400125

💡More info here: https://forgetdiabetes.eu/

30/07/2024

📢 PAPER ALERT 📢

We are proud to announce that our newest review paper, conceived within the framework of the REBORN Project, has just been published on the prestigious Advanced Materials journal! 🚀

🔎 It explores the exciting world of stimuli-responsive medical patches. Thanks to the integration of smart biomaterials, they are able to deliver on-demand local therapy for drug delivery and tissue regeneration applications 🧬🧫

🔗 If you are interested in knowing more, check it out here 👉🏼
https://onlinelibrary.wiley.com/doi/full/10.1002/adma.202310110

06/07/2024

Despite the ADMAIORA Project successfully coming to an end, the RT Lab is now engaged in the clinical translation of the technology.

In the first picture, Dr. Alessandro Russo, orthopaedic specialist at Istituto Ortopedico Rizzoli (Bologna), is testing the arthroscopic tool developed by our team for the in situ deposition of the nanocomposite hydrogel.

In the second picture, the latest publication about usability tests of our telehealth platforms for remote monitoring of knee osteoarthritis among which a mobile app, a thermal camera, and an ultrasound (US) imaging system for remote imaging.

🔗 Do you want to know more about it? 👉🏼 Check the ADMAIORA website and look for the paper in the last publications on www.admaiora-project.com/

                               

04/07/2024

📢 PAPER ALERT 📢
The most important achievements of the ADMAIORA Project on ultrasound-driven cartilage regeneration have been recently published in the prestigious ACS Nano journal!
We are proud that this work was selected for the journal’s cover! 🚀
Read it here 👉🏼 https://pubs.acs.org/doi/full/10.1021/acsnano.3c08738

03/07/2024

➡️ ADMAIORA (full name: ADvanced nanocomposite MAterIals fOr in situ treatment and ultRAsound-mediated management of osteoarthritis) is a 🇪🇺 EU-funded research project focused on groundbreaking treatment against osteoarthritis (OA).

🎯 The project aims, in the long-term, at increasing the healthy and active lifespan of people affected by OA, by considerably slowing down or even stopping the degeneration process, thus delaying by several years or even avoiding surgical interventions for total joint replacement.

🔬 RT Lab is the project coordinator, responsible for developing the nanocomposite hydrogel and the low-intensity pulsed ultrasound platform, as well as designing and developing the arthroscopic 3D bioprinting tool.

🔗 More info here 👉🏼 https://www.admaiora-project.com/

17/03/2024

📸 Have a look at Sofia’s microfluidic chip! 👩🏼‍🔬

💡 It is a device whose micrometric channels allow to handle and mix two or more liquids with great precision 🧪🎯

🔎 In our lab we use it to produce microdroplets 🫧 with a highly controlled core-shell structure, for drug delivery applications, within the REBORN project 🔬💊

13/03/2024

➡️ REBORN (full name: Remodelling of the infarcted heart: piezoelectric multifunctional patch enabling the sequential release of therapeutic factors) is a 🇪🇺 EU-funded research project focused on the development of a smart cardiac patch.

🎯 The project aims at the regeneration of heart tissue after myocardial infarction, by means of a piezoelectric multifunctional patch. Once applied to the heart, it will have the ability to stimulate its activity and deliver anti-inflammatory, anti-fibrotic drugs and proliferative factors under ultrasound stimulation.

🔬 The role of the RT Lab is to develop innovative ultrasound technologies to enable a localized, controlled and sequential release of different drugs.

🔗 More info here 👉🏼 https://rebornproject.eu/

25/01/2024

Last week our PI Leonardo Ricotti participated as an invited speaker at the in (Ventura, USA). He spoke about the latest results of and projects. This conference was an exceptional opportunity to not only showcase our latest results but also to exchange innovative ideas with leading minds in the field.

02/11/2023

Last week, Prof. Leonardo Ricotti participated in a Workshop, organized by I-RIM Istituto di Robotica e Macchine Intelligenti in Rome, during the 5th Italian Conference on Robotics and Intelligent Machines.
The workshop, entitled 'How Soft are these Robots', analyzed the latest advancements in the field of soft and biohybrid robots.

Leonardo Ricotti delivered a talk on “Biohybrid machines: a synergy between artificial and biological components”, in which also the BioMeld project efforts were presented!

Project BioMeld

16/10/2023

Hind Al-Haddad is a PhD student in BioRobotics at the BioRobotics Institute of Scuola Superiore Sant'Anna, within the "Regenerative Technologies" lab.

She holds a Bachelor's degree in Biomedical Engineering from the University of Baghdad, Iraq. A Master's Degree in Bionics Engineering, jointly offered by the University of Pisa and Scuola Superiore Sant'Anna.
During her master's thesis, she worked on developing and characterizing a bilayer hydrogel that mimics the mechanical characteristics of articular cartilage for restoring the area where the articular cartilage was damaged due to trauma or osteoarthritis.

Currently, she is working on developing and optimizing an invisible, fully implanted artificial pancreas to restore the lost functionality of the insulin-dependent patient pancreas. Her work is in the framework of the European project FORGETDIABETES.

She aims to contribute to innovations that will improve human health and health care at all levels. As a result, she is concentrating her efforts on conducting research that will aid in the restoration of everyday life for patients suffering from chronic diseases.

11/10/2023

Post-doc / research assistant positions open at the Regenerative Technologies Lab!
TAKE A LOOK AT OUR WEBSITE 👀➡️https://www.regenerativelab.it/join-us/

Indirizzo

Viale Rinaldo Piaggio, 34
Pontedera
56025

Telefono

+39050883000

Sito Web

https://www.regenerativelab.it/

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