08/01/2026
A research study published in the journal 𝘕𝘢𝘵𝘶𝘳𝘦 𝘊𝘰𝘮𝘮𝘶𝘯𝘪𝘤𝘢𝘵𝘪𝘰𝘯𝘴 reveals a novel mechanism linking mitochondrial dysfunction to cellular senescence. Specifically, mitochondrial RNA (mtRNA) leakage could activate innate immune RNA sensors in the cytosol and drive the Senescence-Associated Secretory Phenotype (SASP), which promotes inflammation and senescence-driven disorders.
https://www.nature.com/articles/s41467-025-66159-z