25/09/2025
WHO statement on autism-related issues
The World Health Organization (WHO) emphasizes that there is currently no conclusive scientific evidence confirming a possible link between autism and use of acetaminophen (also known as paracetamol) during pregnancy.
Globally, nearly 62 million people (1 in 127) have autism spectrum disorder, a diverse group of conditions related to development of the brain. Although awareness and diagnosis have improved in recent years, the exact causes of autism have not been established, and it is understood there are multiple factors that can be involved.
Extensive research has been undertaken over the past decade, including large-scale studies, looking into links between acetaminophen use during pregnancy and autism. At this time, no consistent association has been established.
WHO recommends that all women continue to follow advice of their doctors or health workers, who can help assess individual circumstances and recommend necessary medicines.
Any medicine should be used with caution during pregnancy, especially in the first three months, and in line with advice from health professionals.
Also, a robust, extensive evidence base exists showing childhood vaccines do not cause autism. Large, high-quality studies from many countries have all reached the same conclusion. Original studies suggesting a link were flawed and have been discredited.
Since 1999, independent experts advising WHO have repeatedly confirmed that vaccines - including those with thiomersal or aluminum - do not cause autism or other developmental disorders.
Childhood vaccine schedules are developed through a careful, extensive and evidence-based process involving global experts and country input.
The childhood immunization schedule, carefully guided by WHO, has been adopted by all countries, and has saved at least 154 million lives over the past 50 years. The schedule remains essential for the health and wellbeing of every child and every community. These schedules have continually evolved with science and now safeguard children, adolescents and adults against 30 infectious diseases.
Every vaccine recommendation by the Strategic Advisory Group of Experts on Immunization (SAGE), an independent advisory group to WHO, is grounded in rigorous review of evidence and carefully designed to offer the best protection against serious diseases and to be delivered when most needed.
When immunization schedules are delayed or disrupted, or altered without evidence review, there is a sharp increase in the risk of infection not only for the child, but also for the wider community.
Infants too young to be vaccinated and people with weakened immune systems or underlying health conditions are at greatest risk.
Autism and neurodevelopmental disorders are among priority mental health and neurological conditions being discussed at the 4th UN High-Level Meeting on NCDs and mental health this Thursday, 25 September.
As a global community, we need to do more to understand the causes of autism and how best to care for and support the needs of autistic people and their families.
WHO is committed to advancing this goal working together with partners including autistic-led organizations and other organizations representing persons with lived experience.
WHO also stands with people who are living with autism and their families, a dignified community entitled to evidence-based considerations free of stigma.
