10/08/2025
𝗡𝗲𝘄 𝗥𝗲𝘃𝗶𝗲𝘄 𝗔𝗿𝘁𝗶𝗰𝗹𝗲: 𝗧𝗲𝘀𝘁𝗼𝘀𝘁𝗲𝗿𝗼𝗻𝗲 𝗧𝗿𝗲𝗮𝘁𝗺𝗲𝗻𝘁 𝗳𝗼𝗿 𝗛𝘆𝗽𝗼𝗴𝗼𝗻𝗮𝗱𝗶𝘀𝗺
In men, marked hypogonadism due to pituitary or testicular disease generally has readily recognizable clinical manifestations, such as decreases in libido and s*xual activity, loss of secondary s*x characteristics and muscle mass, hot flushes, and anemia. Testosterone preparations have been approved by regulatory agencies to treat hypogonadism and are effective in correcting the clinical abnormalities associated with this condition in many men. Most men currently treated with testosterone preparations, however, are middle-aged or older and have only moderately decreased testosterone levels, a high burden of chronic diseases, and nonspecific symptoms that overlap with age-related symptoms. The benefits and risks of testosterone treatment in this population are less clear and are associated with controversy. In a new review, Shalender Bhasin, MB, BS, and Peter J. Snyder, MD, consider available information about the benefits and risks of testosterone treatment in middle-aged and older men with moderate degrees of hypogonadism.
Read the Review Article “Testosterone Treatment in Middle-Aged and Older Men with Hypogonadism” by Shalender Bhasin, MB, BS, and Peter J. Snyder, MD, from , , and , at NEJM.org (link in bio).
