05/09/2025
The different types of sickle cell diseases;
Haemoglobin SS Disease (Sickle Cell Anemia): This is the most common and often most severe form, occurring when two sickle cell genes are inherited.
Haemoglobin SC Disease: This is the second most common type, usually milder than HbSS disease, resulting from inheriting one sickle cell gene and one HbC gene.
Haemoglobin S Beta-Thalassemia: This type involves inheriting a sickle cell gene and a beta-thalassemia gene.
Haemoglobin S Beta-Zero Thalassemia: This form is often severe, similar to Haemoglobin SS disease.
Haemoglobin S Beta-Plus Thalassemia: This form is typically milder.
Haemoglobin SE Disease: A rarer type resulting from inheriting an HbS gene and an HbE gene.
Haemoglobin SD Disease: Another rare form, occurring when an HbS gene and an HbD gene are inherited.
Haemoglobin SO Disease: A very rare type, where an HbS gene is inherited along with an HbO gene.
Other Rare Types: There are other even rarer combinations of an HbS gene with different abnormal hemoglobin genes. The severity of these rare types can vary significantly.
