13/02/2026
藤本健二医師が、IDH阻害剤の長期投与がIDH変異型神経膠腫のエピゲノムを変化させ抗腫瘍効果をもたらすことを実験的に示した研究がActa Neuropathologica誌に掲載されました。
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Heterozygous mutations in isocitrate dehydrogenase (IDH) 1 and 2 are hallmarks of astrocytoma, IDH-mutated, and oligodendroglioma, IDH-mutated, as defined by the World Health Organization Classification of Tumors of the Central Nervous System, 5th Edition. Mutant IDH confers a neomorphic enzymatic a...