10/05/2020
Inoue M, Kajiwara K, Yamaguchi A, Kiyono T, Samura O, Akutsu H, Sago H, Okamoto A, Umezawa A. Autonomous trisomic rescue of Down syndrome cells. Lab Invest. 2019, doi: 10.1038/s41374-019-0230-0 (in press).
Yazawa T, Imamichi Y, Sekiguchi T, Miyamoto K, Uwada J, Khan MRI, Suzuki N, Umezawa A, Taniguchi T. Transcriptional Regulation of Ovarian Steroidogenic Genes: Recent Findings Obtained from Stem Cell-Derived Steroidogenic Cells. Biomed Res Int. 2019, 2019:8973076.
Iwai M, Hamatani T, Nakamura A, Kawano N, Kanai S, Kang W, Yoshii N, Odawara Y, Yamada M, Miyamoto Y, Saito T, Saito H, Miyado M, Umezawa A, Miyado K, Tanaka M. Membrane protein CD9 is repositioned and released to enhance uterine function. Lab Invest. 2019, 99:200-209.
Ozeki M, Asada R, Saito AM, Hashimoto H, Fujimura T, Kuroda T, Ueno S, Watanabe S, Nosaka S, Miyasaka M, Umezawa A, Matsuoka K, Maekawa T, Yamada Y, Fujino A, Hirakawa S, Furukawa T, Tajiri T, Kinosh*ta Y, Souzaki R, Fukao T. Efficacy and safety of sirolimus treatment for intractable lymphatic anomalies: A study protocol for an open-label, single-arm, multicenter, prospective study (SILA). Regen Ther. 2019, 10:84-91.
Iwai M, Harada Y, Miyabayashi R, Kang W, Nakamura A, Kawano N, Miyamoto Y, Yamada M, Hamatani T, Miyado M, Yoshida K, Saito H, Tanaka M, Umezawa A, Miyado K. Chemotactic behavior of egg mitochondria in response to s***m fusion in mice. Heliyon. 2018, 4:e00944.
Seko Y, Iwanami M, Miyamoto-Matsui K, Takita S, Aoi N, Umezawa A, Kato S. The manner of decay of genetically defective EYS gene transcripts in photoreceptor-directed fibroblasts derived from retinitis pigmentosa patients depends on the type of mutation. Stem Cell Res Ther. 2018, 9:279.
Iso Y, Usui S, Toyoda M, Spees JL, Umezawa A, Suzuki H. Bone marrow-derived mesenchymal stem cells inhibit vascular smooth muscle cell proliferation and neointimal hyperplasia after arterial injury in rats. Biochem Biophys Rep. 2018, 16:79-87.
Yasuda S, Kusakawa S, Kuroda T, Miura T, Tano K, Takada N, Matsuyama S, Matsuyama A, Nasu M, Umezawa A, Hayakawa T, Tsutsumi H, Sato Y. Tumorigenicity-associated characteristics of human iPS cell lines. PLoS One. 2018, 13:e0205022.
Nakamura A, Kawano N, Motomura K, Kuroda A, Sekiguchi K, Miyado M, Kang W, Miyamoto Y, Hanai M, Iwai M, Yamada M, Hamatani T, Saito T, Saito H, Tanaka M, Umezawa A, Miyado K. Degradation of phosphate polymer polyP enhances lactic fermentation in mice. Genes Cells. 2018, 23:904-914.
Sakai T, Naito AT, Kuramoto Y, Ito M, Okada K, Higo T, Nakagawa A, Shibamoto M, Yamaguchi T, Sumida T, Nomura S, Umezawa A, Miyagawa S, Sawa Y, Morita H, Lee JK, Shiojima I, Sakata Y, Komuro I. Phenotypic Screening Using Patient-Derived Induced Pluripotent Stem Cells Identified Pyr3 as a Candidate Compound for the Treatment of Infantile Hypertrophic Cardiomyopathy. Int Heart J. 2018, 59:1096-1105.
Nishino K, Arai Y, Takasawa K, Toyoda M, Yamazaki-Inoue M, Sugawara T, Akutsu H, Nishimura K, Ohtaka M, Nakanishi M, Umezawa A. Epigenetic-scale comparison of human iPSCs generated by retrovirus, Sendai virus or episomal vectors. Regen Ther. 2018, 9:71-78.
Kang W, Ishida E, Yamatoya K, Nakamura A, Miyado M, Miyamoto Y, Iwai M, Tatsumi K, Saito T, Saito K, Kawano N, Hamatani T, Umezawa A, Miyado K, Saito H. Autophagy-disrupted LC3 abundance leads to death of supporting cells of human oocytes. Biochem Biophys Rep. 2018, 15:107-114.
Yoshida K, Kang W, Nakamura A, Kawano N, Hanai M, Miyado M, Miyamoto Y, Iwai M, Hamatani T, Saito H, Miyado K, Umezawa A. Ubiquitin-activating enzyme E1 inhibitor PYR-41 retards s***m enlargement after fusion to the egg. Reprod Toxicol. 2018, 76:71-77.
Matsunari H, Watanabe M, Nakano K, Enosawa S, Umeyama K, Uchikura A, Yashima S, Fukuda T, Klymiuk N, Kurome M, Kessler B, Wuensch A, Zakhartchenko V, Wolf E, Hanazono Y, Nagaya M, Umezawa A, Nakauchi H, Nagashima H. Modeling lethal X-linked genetic disorders in pigs with ensured fertility. Proc Natl Acad Sci U S A. 2018, 115:708-713.
Bai F, Li Z, Umezawa A, Terada N, Jin S. Bacterial type III secretion system as a protein delivery tool for a broad range of biomedical applications. Biotechnol Adv. 2018, 36:482-493.
Takasawa K, Arai Y, Yamazaki-Inoue M, Toyoda M, Akutsu H, Umezawa A, Nishino K. DNA hypermethylation enhanced telomerase reverse transcriptase expression in human-induced pluripotent stem cells. Hum Cell. 2018, 31:78-86.
Fukuda A, Umezawa A, Akutsu H. Manipulation of Xist Imprinting in Mouse Preimplantation Embryos. Methods Mol Biol. 2018, 1861:47-53.
Fukami M, Suzuki E, Izumi Y, Torii T, Narumi S, Igarashi M, Miyado M, Katsumi M, Fujisawa Y, Nakabayashi K, Hata K, Umezawa A, Matsubara Y, Yamauchi J, Ogata T. Paradoxical gain-of-function mutant of the G-protein-coupled receptor PROKR2 promotes early puberty. J Cell Mol Med. 2017, 21:2623-2626.
Kojima J, Fukuda A, Taira H, Kawasaki T, Ito H, Kuji N, Isaka K, Umezawa A, Akutsu H. Efficient production of trophoblast lineage cells from human induced pluripotent stem cells. Lab Invest. 2017, 97:1188-1200.
Ohno M, Fuchimoto Y, Hsu HC, Higuchi M, Komura M, Yamaoka T, Umezawa A, Enosawa S, Kuroda T. Airway reconstruction using decellularized tracheal allografts in a porcine model. Pediatr Surg Int. 2017, 33:1065-1071.
Kuroda T, Yasuda S, Nakashima H, Takada N, Matsuyama S, Kusakawa S, Umezawa A, Matsuyama A, Kawamata S, Sato Y. Identification of a Gene Encoding Slow Skeletal Muscle Troponin T as a Novel Marker for Immortalization of Retinal Pigment Epithelial Cells. Sci Rep. 2017, 7:8163.
Ikemoto Y, Takayama Y, Fujii K, Masuda M, Kato C, Hatsuse H, Fujitani K, Nagao K, Kameyama K, Ikehara H, Toyoda M, Umezawa A, Miyash*ta T. Somatic mosaicism containing double mutations in PTCH1 revealed by generation of induced pluripotent stem cells from nevoid basal cell carcinoma syndrome. J Med Genet. 2017, 54:579-584.
Ochiai H, Kishi K, Kubota Y, Oka A, Hirata E, Yabuki H, Iso Y, Suzuki H, Umezawa A. Transplanted mesenchymal stem cells are effective for skin regeneration in acute cutaneous wounds of pigs. Regen Ther. 2017, 7:8-16.
Kajiwara K, Tanemoto T, Wada S, Karibe J, Ihara N, Ikemoto Y, Kawasaki T, Oishi Y, Samura O, Okamura K, Takada S, Akutsu H, Sago H, Okamoto A, Umezawa A. Fetal Therapy Model of Myelomeningocele with Three-Dimensional Skin Using Amniotic Fluid Cell-Derived Induced Pluripotent Stem Cells. Stem Cell Reports. 2017, 8:1701-1713.
Yamatoya K, Saito K, Saito T, Kang W, Nakamura A, Miyado M, Kawano N, Miyamoto Y, Umezawa A, Miyado K, Saito H. Birthweights and Down syndrome in neonates that were delivered after frozen-thawed embryo transfer: The 2007-2012 Japan Society of Obstetrics and Gynecology National Registry data in Japan. Reprod Med Biol. 2017, 16:228-234.
Mitani A, Fukuda A, Miyash*ta T, Umezawa A, Akutsu H. The serine 106 residue within the N-terminal transactivation domain is crucial for Oct4 function in mice. Zygote. 2017, 25(2):197-204.
Chen YM, Chen LH, Li MP, Li HF, Higuchi A, Kumar SS, Ling QD, Alarfaj AA, Munusamy MA, Chang Y, Benelli G, Murugan K, Umezawa A. Xeno-free culture of human pluripotent stem cells on oligopeptide-grafted hydrogels with various molecular designs. Sci Rep. 2017, 7:45146.
Uchida H, Machida M, Miura T, Kawasaki T, Okazaki T, Sasaki K, Sakamoto S, Ohuchi N, Kasahara M, Umezawa A, Akutsu H. A xenogeneic-free system generating functional human gut organoids from pluripotent stem cells. JCI Insight. 2017, 2:e86492.
Seko Y, Azuma N, Yokoi T, Kami D, Ishii R, Nishina S, Toyoda M, Shimokawa H, Umezawa A. Can Human Embryonic Stem Cell-Derived Stromal Cells Serve a Starting Material for Myoblasts? Curr Eye Res. 2017, 42:145-154.
Ando Y, Saito M, Machida M, Yoshida-Noro C, Akutsu H, Takahashi M, Toyoda M, Umezawa A. Can Human Embryonic Stem Cell-Derived Stromal Cells Serve a Starting Material for Myoblasts? Stem Cells Int. 2017, 2017:7541734.
Akutsu H, Nasu M, Morinaga S, Motoyama T, Homma N, Machida M, Yamazaki-Inoue M, Okamura K, Nakabayashi K, Takada S, Nakamura N, Kanzaki S, Hata K, Umezawa A. In vivo maturation of human embryonic stem cell-derived teratoma over time. Regen Ther. 2016, 5:31-39.
Yazawa T, Imamichi Y, Miyamoto K, Khan MR, Uwada J, Umezawa A, Taniguchi T. Induction of steroidogenic cells from adult stem cells and pluripotent stem cells [Review]. Endocr J. 2016, 63:943-951.
Fukuda A, Mitani A, Miyash*ta T, Kobayashi H, Umezawa A, Akutsu H. Spatiotemporal dynamics of OCT4 protein localization during preimplantation development in mice. Reproduction. 2016, 152:417-430.
Fukuda A, Mitani A, Miyash*ta T, Sado T, Umezawa A, Akutsu H. Maintenance of Xist Imprinting Depends on Chromatin Condensation State and Rnf12 Dosage in Mice. PLoS Genet. 2016, 12:e1006375.
Imamichi Y, Yuhki KI, Orisaka M, Kitano T, Mukai K, Ushikubi F, Taniguchi T, Umezawa A, Miyamoto K, Yazawa T. 11-Ketotestosterone Is a Major Androgen Produced in Human Go**ds. J Clin Endocrinol Metab. 2016, 101:3582-3591.
Hayakawa T, Harris I, Joung J, Kanai N, Kawamata S, Kellathur S, Koga J, Lin YC, Maruyama Y, McBlane J, Nishimura T, Renner M, Ridgway A, Salmikangas P, Sakamoto N, Sato D, Sato Y, Toda Y, Umezawa A, Werner M, Wicks S. Report of the International Regulatory Forum on Human Cell Therapy and Gene Therapy Products. Biologicals. 2016, 44:467-479.
Nishino K, Umezawa A. DNA methylation dynamics in human induced pluripotent stem cells. Hum Cell. 2016, 29:97-100.
Nakamura A, Hamaguchi E, Horikawa R, Nishimura Y, Matsubara K, Sano S, Nagasaki K, Matsubara Y, Umezawa A, Tajima T, Ogata T, Kagami M, Okamura K, Fukami M. Complex Genomic Rearrangement Within the GNAS Region Associated With Familial Pseudohypoparathyroidism Type 1b. J Clin Endocrinol Metab. 2016, 101:2623-2627.
Komuta Y, Ishii T, Kaneda M, Ueda Y, Miyamoto K, Toyoda M, Umezawa A, Seko Y. In vitro transdifferentiation of human peripheral blood mononuclear cells to photoreceptor-like cells. Biol Open. 2016, 5:709-19.
Fujinaga H, Fujinaga H, Watanabe N, Kato T, Tamano M, Terao M, Takada S, Ito Y, Umezawa A, Kuroda M. Cord blood-derived endothelial colony-forming cell function is disrupted in congenital diaphragmatic hernia. Am J Physiol Lung Cell Mol Physiol. 2016, 310:L1143-1154.
Higasa K, Miyake N, Yoshimura J, Okamura K, Niihori T, Saitsu H, Doi K, Shimizu M, Nakabayashi K, Aoki Y, Tsurusaki Y, Morish*ta S, Kawaguchi T, Migita O, Nakayama K, Nakashima M, Mitsui J, Narahara M, Hayashi K, Funayama R, Yamaguchi D, Ishiura H, Ko WY, Hata K, Nagashima T, Yamada R, Matsubara Y, Umezawa A, Tsuji S, Matsumoto N, Matsuda F. Human genetic variation database, a reference database of genetic variations in the Japanese population. J Hum Genet. 2016, 61:547-553.
Okamura K, Sakaguchi H, Sakamoto-Abutani R, Nakanishi M, Nishimura K, Yamazaki-Inoue M, Ohtaka M, Periasamy VS, Alshatwi AA, Higuchi A, Hanaoka K, Nakabayashi K, Takada S, Hata K, Toyoda M, Umezawa A. Distinctive features of single nucleotide alterations in induced pluripotent stem cells with different types of DNA repair deficiency disorders. Sci Rep. 2016, 6:26342.
Sato H, Ishii Y, Yamamoto S, Azuma E, Takahashi Y, Hamashima T, Umezawa A, Mori H, Kuroda S, Endo S, Sasahara M. PDGFR-β Plays a Key Role in the Ectopic Migration of Neuroblasts in Cerebral Stroke. Stem Cells. 2016, 34:685-698.
Mizukami T, Iso Y, Sato C, Sasai M, Spees JL, Toyoda M, Umezawa A, Miyazaki A, Suzuki H. Priming with erythropoietin enhances cell survival and angiogenic effect of mesenchymal stem cell implantation in rat limb ischemia. Regenerative Therapy. 2016, 4:1-8.
Itakura Y, Sasaki N, Kami D, Gojo S, Umezawa A, Toyoda M. N- and O-glycan cell surface protein modifications associated with cellular senescence and human aging. Cell Biosci. 2016, 6:14.
Park SJ, Komiyama Y, Suemori H, Umezawa A, Nakai K. OpenTein: a database of digital whole-slide images of stem cell-derived teratomas. Nucleic Acids Res. 2016, 44(D1):D1000-1004.
Nasu M, Takayama S, Umezawa A. Efficiency of Human Epiphyseal Chondrocytes with Differential Replication Numbers for Cellular Therapy Products. Biomed Res Int. 2016, 2016:6437658.
Tone H, Yoshioka S, Akiyama H, Nishimura A, Ichimura M, Nakatani M, Kiyono T, Toyoda M, Watanabe M, Umezawa A. Embryoid Body-Explant Outgrowth Cultivation from Induced Pluripotent Stem Cells in an Automated Closed Platform. Biomed Res Int. 2016, 2016:7098987.
Kitajima K, Nakajima M, Kanokoda M, Kyba M, Dandapat A, Tolar J, Saito MK, Toyoda M, Umezawa A, Hara T. GSK3β inhibition activates the CDX/HOX pathway and promotes hemogenic endothelial progenitor differentiation from human pluripotent stem cells. Exp Hematol. 2016, 44:68-74.e1-10.
Hashimoto A, Naito AT, Lee JK, Kitazume-Taneike R, Ito M, Yamaguchi T, Nakata R, Sumida T, Okada K, Nakagawa A, Higo T, Kuramoto Y, Sakai T, Tominaga K, Okinaga T, Kogaki S, Ozono K, Miyagawa S, Sawa Y, Sakata Y, Morita H, Umezawa A, Komuro I. Generation of Induced Pluripotent Stem Cells From Patients With Duchenne Muscular Dystrophy and Their Induction to Cardiomyocytes. Int Heart J. 2016, 57:112-117.
Sivan PP, Syed S, Mok PL, Higuchi A, Murugan K, Alarfaj AA, Munusamy MA, Awang Hamat R, Umezawa A, Kumar S. Stem Cell Therapy for Treatment of Ocular Disorders. Stem Cells Int. 2016, 2016:8304879.
Yokoyama M, Sato M, Umezawa A, Mitani G, Takagaki T, Yokoyama M, Kawake T, Okada E, Kokubo M, Ito N, Takaku Y, Murai K, Matoba R, Akutsu H, Yamato M, Okano T, Mochida J. Assessment of the Safety of Chondrocyte Sheet Implantation for Cartilage Regeneration. Tissue Eng Part C Methods. 2016, 22:59-68.
Hayakawa T, Aoi T, Umezawa A, Ozawa K, Sato Y, Sawa Y, Matsuyama A, Yamanaka S, Yamato M. A study on ensuring the quality and safety of pharmaceuticals and medical devices derived from the processing of human embryonic stem cells. Regenerative Therapy. 2015, 2:109-122.
Hayakawa T, Aoi T, Umezawa A, Ozawa K, Sato Y, Sawa Y, Matsuyama A, Yamanaka S, Yamato M. A study on ensuring the quality and safety of pharmaceuticals and medical devices derived from processing of allogeneic human induced pluripotent stem(-Like) cells. Regenerative Therapy. 2015, 2:95-108.
Hayakawa T, Aoi T, Umezawa A, Ozawa K, Sato Y, Sawa Y, Matsuyama A, Yamanaka S, Yamato M. A study on ensuring the quality and safety of pharmaceuticals and medical devices derived from processing of autologous human induced pluripotent stem(-like) cells. Regenerative Therapy. 2015. 2:81-94.
Hayakawa T, Aoi T, Umezawa A, Ozawa K, Sato Y, Sawa Y, Matsuyama A, Yamanaka S, Yamato M. A study on ensuring the quality and safety of pharmaceuticals and medical devices derived from the processing of allogeneic human somatic stem cells. Regenerative Therapy. 2015, 2:70-80.
Hayakawa T, Aoi T, Umezawa A, Ozawa K, Sato Y, Sawa Y, Matsuyama A, Yamanaka S, Yamato M. A study on ensuring the quality and safety of pharmaceuticals and medical devices derived from the processing of autologous human somatic stem cells. Regenerative Therapy. 2015, 2:57-69.
Nakamura A, Miyado K, Yamatoya K, Kawano N, Umezawa A. Breast milk stimulates growth hormone secretion in infant mice, and phosphorus insufficiency disables this ability and causes dwarfism-like symptoms. Regenerative Therapy. 2015, 2:49-56.
Higuchi A, Kao SH, Ling QD, Chen YM, Li HF, Alarfaj AA, Munusamy MA, Murugan K, Chang SC, Lee HC, Hsu ST, Kumar SS, Umezawa A. Long-term xeno-free culture of human pluripotent stem cells on hydrogels with optimal elasticity. Sci Rep. 2015, 5:18136.
Tsumura H, Ito M, Takami M, Arai M, Li XK, Hamatani T, Igarashi A, Takada S, Miyado K, Umezawa A, Ito Y. Conditional deletion of CD98hc inhibits osteoclast development. Biochem Biophys Rep. 2015, 5:203-210.
Fukuda A, Mitani A, Miyash*ta T, Umezawa A, Akutsu H. Chromatin condensation of Xist genomic loci during oogenesis in mice. Development. 2015, 142:4049-4055.
Miura T, Sugawara T, Fukuda A, Tamoto R, Kawasaki T, Umezawa A, Akutsu H. Generation of primitive neural stem cells from human fibroblasts using a defined set of factors. Biol Open. 2015, 4:1595-1607.
Ojima T, Shibata E, Saito S, Toyoda M, Nakajima H, Yamazaki-Inoue M, Miyagawa Y, Kiyokawa N, Fujimoto J, Sato T, Umezawa A. Glycolipid dynamics in generation and differentiation of induced pluripotent stem cells. Sci Rep. 2015, 5:14988.
Fukuda A, Tanino M, Matoba R, Umezawa A, Akutsu H. Imbalance between the expression dosages of X-chromosome and autosomal genes in mammalian oocytes. Sci Rep. 2015, 5:14101.
Hayakawa T, Aoi T, Bravery C, Hoogendoorn K, Knezevic I, Koga J, Maeda D, Matsuyama A, McBlane J, Morio T, Petricciani J, Rao M, Ridgway A, Sato D, Sato Y, Stacey G, Sakamoto N, Trouvin JH, Umezawa A, Yamato M, Yano K, Yokote H, Yoshimatsu K, Zorzi-Morre P. Report of the international conference on regulatory endeavors towards the sound development of human cell therapy products. Biologicals. 2015, 43:283-297.
Yazawa T, Imamichi Y, Miyamoto K, Khan MR, Uwada J, Umezawa A, Taniguchi T. Regulation of Steroidogenesis, Development, and Cell Differentiation by Steroidogenic Factor-1 and Liver Receptor Homolog-1. Zoolog Sci. 2015, 32:323-330.
Okamura K, Toyoda M, Hata K, Nakabayashi K, Umezawa A. Whole-exome sequencing of fibroblast and its iPS cell lines derived from a patient diagnosed with xeroderma pigmentosum. Genom Data. 2015, 6:4-6.
Mizutani T, Kawabe S, Ishikane S, Imamichi Y, Umezawa A, Miyamoto K. Identification of novel steroidogenic factor 1 (SF-1)-target genes and components of the SF-1 nuclear complex. Mol Cell Endocrinol. 2015, 408:133-137.
Nasu M, Takayama S, Umezawa A. Endochondral ossification model system: designed cell fate of human epiphyseal chondrocytes during long-term implantation. J Cell Physiol. 2015, 230:1376-1388.
Watada Y, Yamash*ta D, Toyoda M, Tsuchiya K, Hida N, Tanimoto A, Ogawa K, Kanzaki S, Umezawa A. Magnetic resonance monitoring of superparamagnetic iron oxide (SPIO)-labeled stem cells transplanted into the inner ear. Neurosci Res. 2015, 95:21-26.
Takeuchi M, Higashino A, Takeuchi K, Hori Y, Koshiba-Takeuchi K, Makino H, Monobe Y, Kishida M, Adachi J, Takeuchi J, Tomonaga T, Umezawa A, Kameoka Y, Akagi K. Transcriptional Dynamics of Immortalized Human Mesenchymal Stem Cells during Transformation. PLoS One. 2015, 10(5):e0126562. Erratum in: PLoS One. 2015;10(6):e0131383.
Mizutani T, Ishikane S, Kawabe S, Umezawa A, Miyamoto K. Transcriptional regulation of genes related to progesterone production. Endocr J. 2015, 62(9):757-763.
Akutsu H, Machida M, Kanzaki S, Sugawara T, Ohkura T, Nakamura N, Yamazaki-Inoue M, Miura T, Vemuri MC, Rao MS, Miyado K, Umezawa A. Xenogeneic-free defined conditions for derivation and expansion of human embryonic stem cells with mesenchymal stem cells. Regenerative Therapy. 2015, 1:18-29.
Ono C, Yoshida M, Kawano N, Miyado K, Umezawa A. Staphylococcus epidermidis is involved in a mechanism for female reproduction in mice. Regenerative Therapy. 2015, 1:11-17.
Nakamura A, MiyadoK, Nasu M, Kono T, Umezawa A. Phosphorus-insufficient maternal milk is associated with ectopic expression of collagen I and female-specific bony changes in infant mouse cartilages. Regenerative Therapy. 2015, 1:5-10.
Inoue T, Umezawa A, Takenaka T, Suzuki H, Okada H. The contribution of epithelial-mesenchymal transition to renal fibrosis differs among kidney disease models. Kidney Int. 2015, 87(1):233-238.
Higuchi A, Ling QD, Kumar SS, Munusamy MA, Alarfaj AA, Chang Y, Kao SH, Lin KC, Wang HC, Umezawa A. Generation of pluripotent stem cells without the use of genetic material. Lab Invest. 2015, 95(1):26-42.
Santostefano KE, Hamazaki T, Biel NM, Jin S, Umezawa A, Terada N. A practical guide to induced pluripotent stem cell research using patient samples. Lab Invest. 2015, 95(1):4-13.
＜特許権等知的財産権の取得及び申請状況＞
機能的肝前駆細胞または機能的肝細胞を調整する方法（出願番号：特願2017-251725。出願日：2018年12月27日、発明者：梅澤明弘、清野透）
非破壊的な細胞検査方法（出願番号：特願2019-24097、出願日：2019年2月14日、発明者：梅澤明弘、他）
人工多能性幹細胞の分化誘導方法（出願番号：特願2014-114190、出願日：2014年6月2日、発明者：梅澤明弘, 阿久津英憲 他）
人工多能性幹細胞標識用試薬及びそれを用いた人工多能性幹細胞標識方法（出願番号：特願2013-129726(P2013-129726)、出願日：2013年6月20日、発明者：梅澤明弘 他）
腸構造体を分化誘導する方法（出願番号：特願2013-121972(P2013-121972)、出願日：2013年6月10日、発明者：梅澤明弘, 阿久津英憲 他）
神経細胞への分化誘導を促進させる細胞培養基材（出願番号：特願2013-121124（P2013-121124）、出願日：2013年6月7日、発明者：阿久津英憲, 梅澤明弘 他）
iPS前駆細胞及びiPS細胞（出願番号：特願2013-82731(P2013-82731)、出願日：2013年4月11日、発明者：阿久津英憲, 梅澤明弘 他）
誘導多能性幹細胞（iPS細胞）の製造方法（出願番号：特願2009-152166(P2009-152166)、出願日：2009年6月26日、発明者：梅澤明弘 他）
＜ノウハウ契約＞
ヒト多能性幹細胞より肝細胞を製造する方法（発明者：梅澤明弘）
軟骨形成能を有する細胞の製造方法（発明者：梅澤明弘 他）
胎盤から初代細胞を作製する方法（発明者：梅澤明弘）
ノウハウは、特許と共に、研究の成果物を保護するための非常に重要なツールである。特許出願を行えば、その発明は公開されることとなる。しかしながら、ノウハウとして発明を管理する方法を選べば、その発明は公開されることはなく、特許出願に比べてより長期に技術のリードタイムを確保することが可能となる。また、このような秘密情報としての管理の他に、第三者に対する技術移転においてもノウハウを活用することができる。先端技術の中には、発明として切り出せる部分以外にも重要な技術情報が多くある。そして、このような技術情報の集積そのものが、第三者にとって価値がある場合がある。したがって、特許情報による発明の管理だけでなく、技術情報全体をノウハウとして管理することが、後の実用化において大きな助けとなることがある。
＜政策提言＞
生物由来原料基準の一部を改正する件（平成26年9月26日制定，厚生労働省告示375号）
再生医療等の安全性の確保等に関する法律施行規則（平成26年9月26日，厚生労働省令第110号）
同種iPS（様）細胞由来網膜色素上皮細胞に関する評価指標（薬食機発0912第2号別添1，平成26年9月12日）
iPS細胞等をもとに製造される細胞組織加工製品の造腫瘍性に関する議論のまとめ（医薬品医療機器総合機構科学委員会細胞組織加工製品専門部会，平成25年8月20日）
自己iPS細胞由来網膜色素上皮細胞に関する評価指標（薬食機発0529第1号別添1，平成25年5月29日）
ヒト幹細胞を用いる臨床研究に関する指針（平成25年10月1日全部改正，厚生労働省告示第317号）
厚生科学審議会科学技術部会 再生医療の安全性確保と推進に関する専門委員会
報告書「再生医療の安全性確保と推進のための枠組み構築について」（平成25年4月18日）厚生労働省医薬食品局「薬事法改正における再生医療製品の位置づけに関する意見交換会」での提言（平成24年度）
ヒト（自己）体性幹細胞加工医薬品等の品質及び安全性の確保に関する指針（薬食発0907第2号，平成24 年9月7日）
ヒト（同種）体性幹細胞加工医薬品等の品質及び安全性の確保に関する指針（薬食発0907第3号，平成24 年9月7日）
ヒト（自己）iPS（様）細胞加工医薬品等の品質及び安全性の確保に関する指針（薬食発0907第4号，平成24 年9月7日）
ヒト（同種）iPS（様）細胞加工医薬品等の品質及び安全性の確保に関する指針（薬食発0907第5号，平成24 年9月7日）
ヒトES細胞加工医薬品等の品質及び安全性の確保に関する指針（薬食発0907第6号，平成24 年9月7日）
