27/04/2026
We are happy to share a follow-up report on the Fbn1G234D aortic dissection mouse model. It is now available online.
Aortic dissection (AD) is characterized by separation within the medial layers of the aortic wall. Pathogenic variants in the fibrillin-1 gene (FBN1), which cause Marfan syndrome, represent a major genetic cause of AD. In a recently established Fbn1G234D/G234D mouse model, intimomedial tears develop...