Oncologist. Cancer care. Doctor Tatiana Turobova - តាត្យ៉ាណា ទូរ៉ូបូវ៉ា

02/12/2025

🧬 CAR T-cell therapy is an FDA-approved therapy that has improved progression-free survival for multiple myeloma, improved overall survival for large B-cell lymphoma, and attained high rates of cancer remission for other hematologic malignancies such as acute lymphoblastic leukemia, follicular lymphoma, and mantle cell lymphoma. This Review summarizes evidence regarding cellular immunotherapies for .

Six CAR T-cell products are approved by the US Food and Drug Administration (FDA) for 6 hematologic malignancies: B-cell acute lymphoblastic leukemia, large B-cell lymphoma, follicular lymphoma, mantle cell lymphoma, chronic lymphocytic leukemia, and multiple myeloma. Compared with standard chemotherapy followed by stem cell transplant, CAR T cells improved 4-year overall survival in patients with large B-cell lymphoma.

CAR T-cell therapy is associated with reversible acute toxicities, such as cytokine release syndrome in approximately 40% to 95% of patients, and neurologic disorders in approximately 15% to 65%. New CAR T-cell therapies in development aim to increase efficacy, decrease adverse effects, and treat other types of cancer.

💾 Save this Review for your bibliography. Find the link in the comments below. ⬇️

01/12/2025

01/12/2025

Small cell lung cancer represents 10% to 15% of all lung cancers, and approximately 16 000 cases were diagnosed in the US in 2024.

📝 This JAMA Patient Page describes small cell lung cancer and its symptoms, diagnosis and staging, treatment, and prognosis.

https://ja.ma/48iYgu2

29/11/2025

🤱🏻ការរៀបចំផែនការមានផ្ទៃពោះ បន្ទាប់ពីការព្យាបាលជំងឺមហារីកសុដន់៖ អនុសាសន៍សំខាន់ៗ | Planning pregnancy after Breast cancer treatment: the main recommendations

❓What is the best time to stop adjuvant endocrine therapy (ET) for Breast cancer (BC) patients who desire to attempt pregnancy?

It is recommended, that patients with a history of hormone receptor-positive invasive BC, who wish to stop ET to attempt pregnancy, complete at least 1️⃣8️⃣ months (1.5 y) of ET before interruption.
The total time of interruption of ET allowed in a scientific investigations was 2 years, including time to conception, pregnancy and breastfeeding.

Patients with higher-risk disease (ex., stage III, high-risk by
genetic testing) should consider longer duration before interruption of ET. Patients with ER-positive DCIS not need to delay childbearing to complete adjuvant ET.

❓How long should patients wait after a stage I-III hormone receptor-negative BC diagnosis to attempt pregnancy?

It is recommended that most patients with a history of hormone receptor negative BC wait at least 2-3 years after the diagnosis and at least 1️⃣ year after completion of treatment before attempting pregnancy.

❓What is the recommended washout period after neo/adjuvant treatment before attempting pregnancy?

Patients, who received chemotherapy and/or radiation. should wait at least 1️⃣ year before attempting pregnancy. Patients who are taking adjuvant ET should have a 3️⃣-month washout period before attempting
pregnancy.

❓Should women, who desire pregnancy, avoid adjuvant bisphosphonates?

Based on the lack of data regarding the safety of pregnancy and
breastfeeding after bisphosphonates, the limited benefit for prevention of bone metastasis, and the low risk of fracture in premenopausal women, AVOIDANCE ❌of bisphosphonates is recommended in patients, who desire pregnancy in the future.

❓Should women with a history of stage I-III BC, who desire pregnancy undergo body imaging prior to pregnancy?

Staging scans may be considered, especially for ladies at high risk of BC recurrence.

https://55933-bcmed.s3.amazonaws.com/bcp/files/flexpaper/pdf/dana-farber-consensus-statement---patients-with-a-history-of-breast-cancer-who-desire-pregnancy.pdf

👩🏻‍⚕️ For all ladies the question about possibility to plan pregnancy after BC treatment has to be discussed with multidisciplinary team of specialists: Medical oncologist, Breast surgeon and ObGyn specialist.

☝🏻During and after pregnancy the lady has to be under control of these specialists too.
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29/11/2025

At Oncology office of Sen Sok IU we provide next examinations:

✔️ Complete blood count (25 parameters), ESR,
✔️ Blood film morphology,
✔️ Biochemistry of blood,
✔️ Blood group and Rh,
✔️ tests ( , , , etc.),
✔️ ( , , , etc.),
✔️ Tumor markers ( , CA15.3, , , etc.),
✔️ Genetic testing for Hereditary cancer syndromes (84 genes) and ,
✔️ Urine tests,
✔️ etc.
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☎️ 070 888 251, 📲 Telegram, WhatsApp 016 669 676 and 087 777 426
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🌏 Google maps: https://maps.app.goo.gl/3LuUPnm4cJQHH2za6
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27/11/2025

❓What is the best place to go for diagnosis and treatment of brain 🧠 tumors (brain cancer) in Cambodia?

☝🏻It is NOT an advertising or paid content. It is just an advise from me, as a Medical oncologist, who has been working in Cambodia from 2010.

👍🏻 The Beast place is National Cancer Center at មន្ទីរពេទ្យកាល់ម៉ែត - Calmette Hospital
3 reasons:
1️⃣ there are MRI machines: MRI is the best way for diagnosis and post-treatment follow-up of brain tumors,
2️⃣ there are specialists-neurosurgeons, who can provide ✔️diagnosis and ✔️surgery treatment of brain tumors,
3️⃣ there is an equipment for Radiation therapy.

✔️Kindly remember about it and share this information to your family and friends.

❤️ Please, stay safe and healthy!
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27/11/2025

👩🏻‍⚕️At Oncology office and Imagery department of Sen Sok IU hospital we provide diagnosis and therapy of BREASTS' CYSTS.

Short information about BREAST CYSTS:
✔️the most frequent benign lesions of breasts,
✔️their content is a fluid,
✔️may be found in one or both breasts,
✔️can be solitary or multiple,
✔️can be small (few mm) and big (2-5 cm),
✔️can be found in women of any age,
✔️can disappear spontaneously or, opposite, can grow fast (ex., before period), after periods it can decrease size and disappear,
✔️they easily identified during ultrasonography,
✔️when a big cyst's presence has been confirmed by ultrasonography, a fine-needle cyst's aspiration (FNA) 💉may be performed.
After draw-up a cyst's content (fluid) into a syringe the cyst often collapsing like a pricked balloon. The fluid will be examined under a microscope🔬,
✔️rarely, cancers can form as cysts and for this reason all aspirated bloodstained fluid needs to be examined under a microscope🔬.

A question about surgery can decide ❗️only well-experiences Breast doctor, because there is just a 10% risk of cancer being associated with a cyst that contains blood, and this type of cyst should be removed.

👩🏻‍⚕️For ladies with simple, small, painless breasts’ cysts we recommend to perform breast-self examination every month and visit Breast doctor every 6-12 months for breast physical examination and ultrasonography of breasts in dynamic.
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For appointment:
📲 Telegram-chat 016 669 676
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⏰Monday - Friday, 7.30 -11.15
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26/11/2025

For Medical oncologists, Imagery specialists and Endocrinologists: a new article (19.11.2025) about thyroid imaging
Ultrasound-based risk stratification systems (RSS), including ACR TI-RADS and EU-TIRADS, provide evidence-based frameworks that enhance diagnostic accuracy and reduce unnecessary biopsies by incorporating key sonographic features and size-specific FNA thresholds.
DTDs, such as Hashimoto thyroiditis and Graves’ disease, are optimally assessed by ultrasound, with characteristic imaging patterns supporting diagnosis in conjunction with thyroid function
tests.
The rising incidence of TC, largely driven by increased imaging, contrasts with stable mortality rates and highlights the need for evidence-based management.
Accurate diagnosis depends on ultrasound, histopathology, and molecular profiling, while optimal care requires multidisciplinary coordination and judicious use of advanced imaging and biopsy techniques.

fil:///C:/Users/DELL/Downloads/s00330-025-12101-2.pdf

https://link.springer.com/article/10.1007/s00330-025-12101-2?fbclid=IwY2xjawOTk-NleHRuA2FlbQIxMABicmlkETFQcmIzRGJ1c3h4TEQ3ckJNc3J0YwZhcHBfaWQQMjIyMDM5MTc4ODIwMDg5MgABHh1uPHQe8YLoyU3hdgs_au_koNQJyd84lQz8zq2Em8IKdi7D7ZgEv6iEorS0_aem_T2lbzObKo-qPUBf-1ruy8Q

Abstract Thyroid nodules are frequently encountered at imaging, yet most are benign and do not require intervention. The clinical challenge lies in distinguishing nodules that warrant further investigation from those that do not, to avoid unnecessary biopsies, anxiety, and overtreatment. Ultrasound....

25/11/2025

☢️ ហើមសុដន់បន្ទាប់ពីការព្យាបាលដោយកាំរស្មីបន្ទាប់ពីការវះកាត់សុដន់សម្រាប់ជំងឺមហារីកសុដន់៖ តើវាមានរយៈពេលប៉ុន្មាន និងរបៀបគ្រប់គ្រង? | Breast edema after Radiation therapy following breast-conserving surgery for Breast cancer: how long does is last and how to manage?

After Radiation therapy (RT) many ladies experience swelling (edema), heaviness, and a feeling of "tightness" in breasts.

ℹ️ This is a common side-effect caused by fluid leakage into breast tissues due to inflammation and damage to the lymphatic system, causing tissues to become denser and "accumulate" fluid.

ℹ️ Symptoms:
✔️ Swelling: the breast may feel heavier or increase in size,
✔️ Skin changes: you may notice skin thickening, redness, tenderness, or a "peau d'orange" (orange peel) appearance,
✔️ ni**le swelling,
✔️ heaviness and pain.

⏰How long does swelling last?
✔️mild swelling may persist 2-6 months after finishing RT,
✔️moderate to severe post-radiation edema can sometimes last up to 12 months, gradually decreasing.

ℹ️ How to manage breast edema:
✔️ wear a supportive bra without underwires,
✔️ avoid activities that put pressure on the chest or arm, such as heavy lifting,
✔️ do gentle exercise: range-of-motion exercises, walking, or swimming,
✔️ protect your skin: keep the skin in the treated area clean and moisturized to prevent cracks and infection,
✔️apply cold packs to relieve discomfort.

👩🏻‍⚕️When to contact your doctor? If you notice:
♦️ a sharp increase in breast size,
♦️ redness, warmth, severe pain,
♦️ lumps that are growing,
♦️ asymmetry that is getting worse,
♦️persistent swelling without changes during few weeks or months.

☝🏻Please, note: recovery from RT is a journey, and it's different for everyone.
Don't compare yourself to others: everyone has different tissue sensitivities and treatment histories.
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25/11/2025

New article for Medical oncologists

Non-small cell lung cancer (NSCLC) is the third most common cause of bone metastases (BoMs), following breast cancer and prostate cancer. At diagnosis, approximately 20–30 % of patients with NSCLC present with BoMs, and an additional 35–60 % will develop bone disease during their illness. BoMs...

25/11/2025

📝Clinical case of 1) suspicious for malignancy and 2) benign right breast lesions: you can see difference between them on ultrasonography pictures and mammograms

👩🏻 Yesterday one 46 y.o. lady came to see me for Breast cancer screening. She did not do any breasts examinations > 3 years.
When the woman was young, she had a right breast mass, which disappeared during the 1st pregnancy.
Few weeks ago the lady found the right breast mass again during breast self-examination.

🖐🏻 During physical examination: the left breast shows no signs of pathology; in the right breast at 12 o'clock (12 OC) there is a lump, approximately 2 cm in size, slightly mobile, and painless. The overlying skin is normal, and the axillary lymph nodes are not enlarged.

👀 During mammography: left breast - without signs of pathology (BI-RADS I). In the right breast there are 2 benign calcifications and there is a spiculated area 1 x 2 cm with microcalcifications (inside of the yellow circle on the 2d picture) - suspicious lesion (BI-RADS IVc).

👀 During breasts ultrasonography: left breast - without signs of pathology (BI-RADS I). No enlarged axillary lymph nodes. In the right breast there are 2 lesions:
✔️ probably benign at 10 OC (on the lower part of the 3d picture) - one nodule 4x5x7 mm, well-defined, with regular contour, without Doppler-signal inside,
✔️ highly suspicious for malignancy at 12 OC (the upper part of the 3d picture and the 4th picture): hypoechoic node with vertical orientation, spiculated, ill-defined, 7x8x13 mm, with signs of hypervascularization (BI-RADS IVc).

💉Core-needle biopsy of the right breast mass at 12 OC was performed.

ℹ️ Now we will wait histology confirmation of oncology disease.

☝🏻After confirmation in plans:
- immunohistochemistry examination of the specimen,
- blood work,
- CT-scan chest and abdomen with contrast,
- radical surgery treatment with one more histology examination of the removed specimen, after which we will decide about next steps of cancer treatment.
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⏰Breast cancer screening: Monday-Friday, 7.30-11.15 AM
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📲For appointments: Telegram-chat 016 669 676 (text-message during working hrs)
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24/11/2025

For Medical oncologists and Radiologists: it is a very interesting investigation

AI demonstrated substantially improved PDAC detection on routine CT scans compared to radiologists on average, showing potential to detect cancer earlier and improve patient outcomes.