12/05/2022
Do you know?
❌ How HP bacteria work in the stomach?
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💢 According to many studies, gastric mucosal damage caused by H.P causes gastric ulcers through 3 different mechanisms:
Changes in gastric physiology,
◾ Direct poisoning from bacterial products,
◾ Inflammatory reactions with the release of various toxic reaction products.
🔰 If the infection is not treated, after 10-20 years the gastric mucosa will atrophy, increasing gastric pH to 6-8. Gland loss, atrophic gastritis, and intestinal metaplasia may initiate the malignancy stage.
🔰 Mechanism of causing damage of Helicobacter pylori to the stomach begins from entering the body for many reasons, after attaching to the cell membrane through receptors, secreting endotoxins. endocytotoxin) directly damages gastric epithelial cells, causing degeneration, necrosis, cell shedding, creating conditions for acid - pepsin to pe*****te and destroy, causing erosion and ulceration.
🔰 Because H.P damages the gastric mucosa, somatostatin secretion will decrease, causing an increase in blood gastrin from producing cells, which mainly increases gastrin (from the antrum), while gastrin (from the duodenum) increases insignificantly. The above result increases parietal cells in the body, increases acid secretion and is accompanied by increased activation of pepsinogen to pepsin. These are the two main attack factors in the pathogenesis of peptic ulcer.
🔰The body is infected with H.P, producing antibodies against H.P. These antibodies cross-react with similar components on the body's gastric epithelial cells, causing damage to the gastric mucosa.
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