CK Regeon

28/06/2023

One of the influencers from Twitter posted PTD-DBM as the hair loss miracle peptide and mentioned it as the potential to become a game-changer for hair growth. Its features include follicle neogenesis and promoting hair cell proliferation, etc.

CK Regeon Inc. which originally developed the PTD-DBM is developing a product that is much more powerful than PTD-DBM with longer stability. If the product comes out, who is interested?

https://lnkd.in/gnG_25PM

/β-catenin-signaling-pathway # Dishevelled # humanhairfollicledermalpapillacell # proliferatingcell nuclearantigen # wound-inducedhairfollicleneogenesis # androgeneticalopecia # CXXC5-Dvl-protein-protein-interaction

“is PTD-DBM the hair loss miracle peptide nobody is talking about? it’s a CXXC5 inhibitor that supports β-catenin signaling - follicle neogenesis - supports anagen induction/duration - synergizes w/ other tools experimental, but could be a gamechanger for hair regrowth”

26/06/2023

Alzheimer’s disease (AD) is the most prevalent type of dementia and is characterized by cognitive deficits and accumulation of pathological plaques. Owing to the complexity of AD development, paradigms for AD research and drug discovery have shifted to target factors that mediate multiple pathogenesis in AD.

Increasing evidence suggests that the suppression of the Wnt/β-catenin signaling pathway plays substantial roles in AD progression. However, the underlying mechanism for the suppression of Wnt/β-catenin pathway ssociated with AD pathogenesis remains unexplored.

In this study, we identified that CXXC5, a negative feedback regulator of the Wnt/β-catenin pathway, was overexpressed in the tissues of AD patients and 5xFAD transgenic mice paired with the suppression of Wnt/β-catenin pathway and its target genes related to AD. The level of CXXC5 was upregulated, upon aging of 5xFAD mice.

AD characteristics including cognitive deficits, amyloid-β (Aβ) plaques, neuronal inflammation, and age-dependent increment of AD-related markers were rescued in Cxxc5-/-/5xFAD mice. 5-methoxyindirubin-3'-oxime (KY19334), a small molecule that restores the suppressed Wnt/β-catenin pathway via interference of the CXXC5-Dvl interaction, significantly improved the overall pathogenic phenotypes of 5xFAD mice.

Collectively, our findings revealed that CXXC5 plays a key role in AD pathogenesis and suggest inhibition of CXXC5-Dvl interaction as a new therapeutic approach for AD.

Article Link:
evier.com/sd/article/S1043-6618(23)00192-5

/β-catenin-signaling-pathway -/-/5xFADmice # CXXC5-Dvl-protein-protein-interaction

30/05/2023

I am speaking at BIO 2023 on June 7th, 2023 in Boston, USA. To join me, click here.

https://www.bio.org/events/bio-international-convention/speakers/1974313

#β-catenin

22/05/2023

Imagine what we can do if we stand together. Meet with us at the 2023 BIO International Convention, June 5-8. Find our company in the partnering system for potential meetings at the largest gathering of the global biotech community!

#β-catenin

11/05/2023

CK Regeon Inc. is speaking and participating in person.
Join me at the worlds largest biotech gathering in Boston, June 5-8, 2023.

#β-catenin

27/04/2023

With over 44,000+ projected meetings to happen over four days, we're excited to meet with likeminded companies that stand up for science. Find our company. CK Regeon Inc. in the BIO's One-on-One Partnering System for potential meetings at the largest gathering of the global biotech community!

#β-catenin

14/04/2023

This image shows the mechanism through which the novel HA-PG adhesive hydrogel patch delivers a combination drug therapy to facilitate regenerative wound healing.

Wound healing and scar reduction are important goals of wound therapies which can now be achieved by novel regeneration promoting materials

During wound healing, human fetal skin develops normal, scar-free skin tissue after injury. This phenomenon, called regenerative healing, is enabled by the abundance of stem cells and the protein Collagen III. However, adult human skin does not undergo regenerative healing, which results in scarring.

Triggering the regenerative healing pathways in adult humans could minimize scarring during wound healing, which can improve the quality of life for patients suffering from various types of wounds.

According to a research article in Advanced Healthcare Materials, a team of scientists led by Dr. Kang-Yell Choi at the Yonsei University in Korea have devised a novel patch for delivery of pro-regenerative material that can promote regenerative wound healing in mice.

This patch could act as a potential therapeutic agent for wound healing and scar reduction in different kinds of acute and minor wounds. It may also find applications in the treatment of chronic wounds like bedsores or diabetic foot ulcers.

“We developed and used a pyrogallol-functionalized hyaluronic acid (HA-PG) patch as a drug delivery system for local and sustained delivery of pro-regenerative materials to the wounds.” says Dr. Choi. Hyaluronic acid is known to promote cellular movement and trap water, aiding regeneration in human fetuses. The high affinity of the pyrogallol molecule for multiple substrates allows the simultaneously delivery of multiple materials that work synergistically.

In mouse models, the HA-PG patch showed clear self-crosslinking abilities and excellent tissue-adhesiveness. The HA-PG patch could effectively deliver a combination of two substances: protein transduction domain-fused Dishevelled-binding motif (PTD-DBM) and valproic acid (VPA).

Both of these are known to promote wound healing in mice by activating the regenerative Wnt/?-catenin signaling pathway.
The HA-PG patches with PTD-DBM and/or VPA brought about an increase in the expression of stem cells at the wound site. They achieved this through the suppression of differentiated cell markers and promotion of stem cell markers in the cells at the wound site.

The production of Collagen III, which is associated with scarless wound healing, was also noted. As Dr. Choi mentions, “Collectively, these data show that the HA-PG patches with PTD-DBM and/or VPA not only promote cutaneous wound healing but also inhibit scar formation.”

Thus, treatment with HA-PG patches loaded with PTD-DBM and/or VPA not only promotes wound healing, but also produces Collagen III which is an important factor for scarless regenerative healing. There are no reported adverse effects of long-term treatment with PTD-DBM on the skin, making this a safe treatment option.

The pro-regenerative materials targeting the regenerative signaling pathway could be highly beneficial for the treatment of many patients by inducing regeneration in various damaged tissues, including skin wounds.

< Photo credits: Dr. Kang-Yell Choi, Yonsei University, CEO of CK Regeon Inc.>

#씨케이리제온

31/03/2023

We are excited to share that your work, published in British Journal of Pharmacology, is among our most downloaded papers!*

KY19382, a novel activator of Wnt/beta-catenin signalling, promotes hair regrowth and hair follicle neogenesis

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07/10/2022

07/10/2022

CK Regeon was founded in October 10th, 2016. Now, CK Regeon aims to develop first-in-class drugs with clear MOA and become a leader in the future bio-medical industry.

#β-catenin

19/09/2022

We support world Alzheimer's day.

www.ckregeon.com

diseaasecauses #β-catenin

05/09/2022

WNT Pathway restoration, a therapeutic target for safe tissue regeneration.

#β-catenin

www.ckregeon.com