Healthy life by meera

21/06/2025

11/05/2025

Omeprazole vs. Esomeprazole – What’s the Difference?

Before we dive into the differences, let’s understand the basics.

Both Omeprazole and Esomeprazole are prescribed for patients suffering from:

Peptic ulcers

Zollinger-Ellison syndrome

Gastroesophageal reflux disease (GERD)

These medications are taken on an empty stomach to ensure they pass through the stomach and reach the intestines, where they are absorbed effectively.

How Do They Work?

Once absorbed, part of the drug is metabolized by the liver enzyme CYP2C19, while the rest diffuses passively into the bloodstream due to its high lipophilicity. From the blood, it reaches the parietal cells in the stomach lining — which have a highly acidic environment.

There, the drug gains a proton and is converted into its active form, sulfenamide, which binds irreversibly to the H+/K+ ATPase enzyme (the proton pump). This prevents hydrogen ion secretion into the stomach, reducing both:

Basal acid secretion (naturally occurring)

Stimulated acid secretion (due to external triggers like NSAIDs)

What’s the Difference Then?

While both drugs share the same chemical structure, they differ in their spatial (stereoisomeric) arrangement.

Omeprazole is a mixture of two mirror-image forms: R- and S-isomers

Esomeprazole contains only the S-isomer, which has a higher binding affinity to the proton pump and is more effective

Why does that matter?

Because the R-isomer is less efficient and is metabolized more variably by CYP2C19 — an enzyme whose activity differs between individuals, especially in East Asian populations.

If CYP2C19 activity is high, Omeprazole is metabolized faster → lower drug levels in blood

If activity is low, the drug stays longer → higher drug levels

This variability leads to inconsistent drug efficacy.

On the other hand, Esomeprazole is metabolized mainly by CYP3A4, an enzyme with more consistent activity across populations.
→ This leads to more stable blood concentrations and higher bioavailability (about 90%, compared to 60% for Omeprazole).

13/03/2025

#التمر #الصحة #رمضان

05/03/2025

Healthy suhoor options:
_1 tsp of peanut butter
_1/2 cup of watermelon cupes
_ 1 cup yogurt of ur choice flavor 0 fat
_ you can add 5 raw almonds

04/03/2025

معليش بدي احكي بعيد عن الأكل و الدايت شوي....
لحبيبي و شريكي بشغل و داعمي الاول و الأخير بدي الك من كل قلبي شكرا عا كل شي ❤️❤️..

20/02/2025

Nothing like a warm matcha latte on a snowy day🍵

18/02/2025

This is images of my routine day what I eat most of my time ... I really like to eat avocado fruits so it's going to be most of my daily diet plan
And usually I eat specific type of fruits
And of course the matcha
About the sport part to be honest I try to do 2 to 3 times per week some training that could help me

This life plan helped me a lot... Have a same shape and weight for more than 5 years ... And to fight a lot of sickness time in my life .. lot of love ❤️

هذه صور من روتيني اليومي الذي أتناوله في أغلب أوقاتي... أحب حقًا تناول فاكهة الأفوكادو لذا ستكون معظم خطتي الغذائية اليومية وعادةً ما أتناول نوعاً محدداً من الفاكهة وبالطبع الماتشا فيما يتعلق بالجزء الرياضي لأكون صادقًا، أحاول القيام ببعض التدريبات مرتين إلى ثلاث مرات أسبوعيًا والتي يمكن أن تساعدني خطة الحياة هذه ساعدتني كثيرًا... أن أكون بنفس الشكل والوزن لأكثر من 5 سنوات... وأن أحارب الكثير من أوقات المرض في حياتي.. الكثير من الحب ❤️

18/02/2025

Why I always prefer fruit as snack not something else ?! ... Well this is the reason

23/01/2025