Extracellular Vesicles & Cancer

10/08/2021

Is syntenin-1 the first of the long-awaited exosomes universal markers? Join the discussion this Wednesday to discover it.
Paper: https://www.nature.com/articles/s41556-021-00693-y
Wednesday, August 11, 12 noon EDT/18.00 CEST/12 AM CST
Login here: https://jhjhm.zoom.us/j/97543276379...
Waiting room opens 30 minutes before the event

Join us this Wednesday for as Fernanda Kugeratski presents her work on the proteome of and the identification of syntenin-1 as a possible universal biomarker.
Uta Erdbrügger and Luca Musante will moderate the discussion.

https://www.nature.com/articles/s41556-021-00693-y

When? Wed, 11 August, 12 noon EDT (GMT-4), 18.00 CEST, 12 AM CST
Need the login? Sign up at: https://www.surveymonkey.com/r/L25KDWB
ISEV International Society for Extracellular Vesicles
Ken Witwer

23/11/2020

Our Projects: "Clinical utility of extracellular vesicle-enclosed human and microbial transcriptomes" funded by the European Regional Development Fund and in collaboration with Riga East Hospital and SIA "GenEra".

In one of our previous studies, we discovered the presence of microbial RNA fragments inside EVs isolated from different human biofluids. Thus, sparked our curiosity and we decided to dig deeper in the topic.

The main aim of this project is to gain new knowledge about the composition and origin of RNA cargo of EVs circulating in cancer patients’ blood, and to assess the clinical utility of EV-enclosed human and microbial RNAs for the diagnosis, prognosis and tracking disease progression in three distinct types of cancer – prostate, breast and gastric cancer.

You can check our latest updates of the project in the following link: http://biomed.lu.lv/en/research/projects/all-projects/clinical-utility-of-extracellular-vesicle-enclosed-human-and-microbial-transcriptomes/

23/11/2020

Have you ever wonder how would it be to see the inside of a cell in 3D? And how the EVs are released from an inside perspective? Then, do not miss out the following video!
!

Excellular vesicles are small areas of cellular membranes that bud inwardly or outwardly, often carrying cargo from one cell to another. Research is only now...

23/11/2020

Our projects: PROSCANEXO 🇱🇻🇪🇸🇪🇪🇳🇴🇳🇱
A project aiming to develop a novel, ultrasensitive lateral flow assay for the detection of EVs in human urine that would enable simple, fast and robust point-of-care diagnosis of prostate cancer. The project is carried out in collaboration with the CIBER (Spain), Erasmus Medical Center (The Netherlands); Oslo University Hospital & Norwegian Radium hospital (Norway) & The University of Tartu (Estonia).

Our main tasks have been:
1) Selecting & optimizing the best extraction method for urinary EVs.

2) Testing RNA biomarkers by qRT-PCR in a set of patients and controls.

3) Establishing ddPCR assays for the absolute quantification of the most relevant RNA biomarkers

4) Primary validation of RNA markers and final assay conditions to be tested.

Soon we will be ready to show some interesting results!Keep posted!

16/11/2020

Wondering what are the main topics that we focus on?