Mayo Pathology Lab

15/03/2023

Que no se te pase, tu salud es lo más importante. Contamos con una gama de estudios de laboratorio, no dudes en preguntar. 👌🔬

10/06/2022

Médula ósea 🩸🔬🔬

23/03/2022

Paciente con anemia megaloblástica.

06/02/2022

Mycobacterium Tuberculosis. 🔬

22/01/2022

14/01/2022

Leukocytosis with left-shifted myeloid maturation in a peripheral blood specimen: a clue to the lymphoid blast phase of CML

A 57-year-old woman with no known medical history presented with fatigue and weakness. Her complete blood count showed white blood cell count, 413.6 × 109/L; hemoglobin level, 83 g/L; and platelet count, 244 × 109/L. A review of the peripheral blood smear showed 37% blasts with irregular nuclear contours, fine chromatin, and scant agranular cytoplasm. Other prominent findings included leukocytosis with left shift, mild basophilia, and eosinophilia (panels A-F; original magnification, ×1000). Flow cytometry of a peripheral blood specimen showed 34% blasts with the following immunophenotype: CD19+/CD10+/cytoCD22+/cytoCD79a+/TdT+/CD34partial+/CD20partial+/CD38(decreased+)/CD45 dim+/cytoCD3−/MPO−/κ−/λ− (panel G), diagnostic of B-cell acute lymphoblastic leukemia (B-ALL). Left-shifted myeloid maturation and eosinophilia were illustrated by flow cytometric immunophenotyping (panel G). Concurrent cytogenetics analysis showed an abnormal karyotype: 46,XX,t(9;22)(q34.1;q11.2)[17]/47,idem,+der(22)t(9;22)(q34.1;q11.2)[3]. Fluorescence in situ hybridization with a tricolor, dual-fusion BCR/ABL1 probe set revealed 77.5% cells with dual-fusion signals (1R1G2F2A) and 16.5% with an abnormal pattern (1G3F1A). Molecular testing by reverse transcription polymerase chain reaction showed a p210 BCR-ABL1 fusion transcript. Subsequent bone marrow biopsy showed 90% to 100% cellularity predominantly involved by B-ALL.
The overall findings in this case were diagnostic of B-ALL. The clinical and laboratory features were highly suggestive of the B-lymphoid blast phase of chronic myeloid leukemia (CML). This case is an example of leukocytosis with myeloid left-shift maturation providing a clue for diagnosing the B-lymphoid blast phase in a patient with undiagnosed CML.
https://ashpublications.org/blood/article/139/2/305/483353/Leukocytosis-with-left-shifted-myeloid-maturation

04/01/2022

Cromosomas humanos. Tinción de Giemsa 🔬citogenética.
Que este año cumplan cada una de sus metas.

23/10/2021

Leucemia mieloide crónica 🔬

🔬Leucemia Mieloide Crónica.
🧪BCR-ABL: +

El cromosoma 22 truncado que resulta de la translocación recíproca t (9; 22) (q34; q11) se conoce como el cromosoma Filadelfia (Ph) y es un sello distintivo de la leucemia mieloide crónica (LMC).

15/08/2021

La historia clínica es importante. Hombre 78 años con sangrados de tubo digestivo alto, por consumó crónico de medicamentos. Hb de 6 gr/dL.
Diagnóstico: Anemia por deficiencia de Hierro 🔬🩸
EHDL Ricardo Bautista.
Especialista en Hematopatología: Elyel Mayo.

02/08/2021

🔬🩸

Único linfócito normal! (Seta)

Paciente, apresentando tumor de crescimento rápido no mediastino, fez vários exames laboratoriais. No hemograma foi observada uma discreta leucocitose com evidente linfocitose com PREDOMÍNIO DE CÉLULAS LINFÓIDES (imagem), sugerindo o Linfoma Primário de Grandes Células B do Mediastino (raro no sangue periférico).

Confirmado por exames complementares. A paciente já está em tratamento.

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