OaxaCannabis

30/03/2026

https://www.facebook.com/photo/?fbid=1516214793209279&set=a.528642321966536

As restrictions on cannabis relax, scientists are investigating long-held beliefs about the drug—and their findings change a lot of what we thought we knew.

For example, it’s often said that cannabis has few side effects and can effectively relieve pain. But recent research suggests that this might not actually be the case. So what's fact from fiction? https://on.natgeo.com/Jmfup8

07/03/2026

In Vitro Antimicrobial Effect of THC on the primary carious pathogen Streptococcus mutans. and Its Anticariogenic Potential.
THC inhibits S mutans growth and biofilm formation while also reducing bacterial viability, EPS production, and acid production. Although it does not degrade preformed biofilm biomass, THC diminishes its metabolic activity and viability. These effects may be linked to THC-induced membrane hyperpolarization. This in vitro study suggests that THC may reduce the cariogenic capacity of S mutans.
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Efecto antimicrobiano in vitro del THC sobre el principal patógeno causante de caries, Streptococcus mutans, y su potencial anticariogénico.
El THC inhibe el crecimiento de S. mutans y la formación de biopelículas, al tiempo que reduce la viabilidad bacteriana, la producción de EPS y la producción de ácido. Aunque no degrada la biomasa de la biopelícula preformada, el THC disminuye su actividad metabólica y su viabilidad. Estos efectos pueden estar relacionados con la hiperpolarización de la membrana inducida por el THC. Este estudio in vitro sugiere que el THC puede reducir la capacidad cariogénica de S. mutans.

https://www.sciencedirect.com/science/article/pii/S0020653925086678

03/03/2026

https://www.facebook.com/photo/?fbid=1462670591980472&set=a.568782714702602

400-year-old pipe fragments from Shakespeare’s garden have traces of cannabis on them.

Modern science is casting a new light on the Elizabethan era after researchers used gas chromatography mass spectrometry to analyze pipe fragments found on William Shakespeare’s property. The study, published in the South African Journal of Science, identified cannabis residue on several items excavated from the playwright's garden in Stratford-upon-Avon. While the discovery does not definitively prove the "Swan of Avon" was the one lighting up, it confirms that the substance was present in his immediate environment during the peak of his career. Interestingly, other pipes found in the surrounding area even showed traces of Peruvian co***ne, highlighting a surprisingly diverse world of botanical exploration in the 17th century.

The findings have breathed new life into theories surrounding Shakespeare’s Sonnet 76, where he famously writes about "invention in a noted w**d" and "compounds strange." While many scholars argue these phrases refer to clothing or general herbs, some believe they might be a subtle nod to the mind-stimulating properties of cannabis. Skeptics maintain that the pipes could have belonged to visitors or household staff, yet the intersection of archaeological evidence and poetic wordplay continues to fascinate. Whether or not Shakespeare was personally under the influence, the presence of these substances suggests that the creative culture of the 1600s may have been far more complex than history books originally let on.

source: Thackeray, J. F. Shakespeare, plants, and chemical analysis of 17th-century clay pipes from Stratford-upon-Avon. South African Journal of Science.

18/02/2026

Check out this vintage gem from the Kohler Manufacturing Co.—a real patent medicine bottle of "One Night Cough Syrup" that promised to knock out your cough in a single night so you could finally rest easy.

Sold over-the-counter in the late 1800s through the early 1900s (with labels evolving by the 1910s–1930s era), this remedy packed quite the punch with its bold ingredient list!

Breaking down the key components straight from the label:

Alcohol (less than 1%) — A common base for many old tonics to help with soothing and preservation.

Cannabis Indica (4 grains per ounce) — Yes, cannabis extract was a standard ingredient in many medicines back then for its calming and pain-relieving properties.

Chloroform (2 minims) — Used as a sedative and cough suppressant (though we now know it carried serious risks like cardiac issues).

Morphia Sulph. (morphine sulfate, about ⅛ grain) — A powerful opioid derived from the poppy plant, included for its strong cough-suppressing and pain-easing effects.

This combo was typical of the era's patent medicines—before strict modern regulations like today's FDA standards kicked in fully.

Manufacturers like Kohler in Baltimore created these "miracle" remedies that blended narcotics, sedatives, and botanicals to deliver fast relief (and often deep sleep!).

While incredibly effective for silencing a cough, they highlight how far pharmaceutical safety and drug regulation have come—many of these substances are now tightly controlled or banned in consumer products due to addiction potential and health risks.

18/02/2026

A review concluded that cannabinoids exert multi-target neuroprotection in ischaemic stroke by improving cerebral blood flow, reducing brain oedema and blood–brain barrier permeability, and inhibiting oxidative stress, neuroinflammation, apoptosis, and excitotoxicity.
Exploring the neuroprotective effects and underlying mechanisms of medical cannabinoids in ischemic stroke.
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Una revisión concluyó que los cannabinoides ejercen una neuroprotección multiobjetivo en el accidente cerebrovascular isquémico al mejorar el flujo sanguíneo cerebral, reducir el edema cerebral y la permeabilidad de la barrera hematoencefálica, e inhibir el estrés oxidativo, la neuroinflamación, la apoptosis y la excitotoxicidad.
Exploración de los efectos neuroprotectores y los mecanismos subyacentes de los cannabinoides médicos en el accidente cerebrovascular isquémico.

https://www.frontiersin.org/journals/neuroscience/articles/10.3389/fnins.2025.1731738/full

09/02/2026

Un estudio demostró que el CBD induce la apoptosis en células cancerosas humanas, al tiempo que retrasa los procesos apoptóticos en células de control no malignas. Estos hallazgos subrayan el potencial del CBD como agente terapéutico complementario para el tratamiento del cáncer, destacando sus efectos citotóxicos selectivos sobre las células malignas con un impacto limitado en las células no malignas.
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Study demonstrated that CBD induces apoptosis in human cancer cells while delaying apoptotic processes in non-malignant control cells. These findings underscore the potential of CBD as an adjunctive therapeutic agent for cancer treatment, highlighting its selective cytotoxic effects on malignant cells with limited impact on non-malignant cells.

https://www.mdpi.com/1422-0067/26/24/12136

Foto de HippoPX.

09/02/2026

Cannabis, particularly low-dose THC and CBD, may improve cognitive function in older adults by reducing brain inflammation, boosting neurogenesis in the hippocampus, and enhancing neural connectivity. It potentially reverses age-related decline by stimulating CB1 receptors, improving memory, learning, and processing speed while preserving brain volume in key areas. 

🗂️Key Mechanisms for Cognitive Improvement 

📑Neuroprotection and Anti-inflammatory Effects: CBD reduces oxidative stress and neuroinflammation, which are common in aging brains and linked to neurodegenerative conditions.

📑Restoring Brain Function via Low-Dose THC: Preclinical studies suggest very low-dose THC can reverse age-related declines in cognitive performance by acting on the endocannabinoid system.

📑Improved Neural Connectivity: Cannabis use in older adults has been associated with greater functional connectivity between the hippocampus and cerebellum, areas vital for memory and learning.

📑Neurogenesis: Daily stimulation of cannabinoid receptors has been shown to increase the growth of new neurons in the hippocampus. 

🗂️Impact on Cognitive Domains:

📑Memory and Processing: Studies have linked lifetime cannabis use to better performance in processing speed, attention, and working memory.

📑Neural Structure: Lifetime use has been associated with larger brain volumes in CB1-rich regions like the caudate, putamen, and hippocampus.

12/11/2025

Los cannabinoides en la investigación preclínica de la sepsis: una revisión exhaustiva.
Los cannabinoides son dianas terapéuticas prometedoras en el tratamiento de la sepsis, ya que mejoran la supervivencia y reducen la inflamación y las lesiones orgánicas. Sin embargo, se notificaron efectos adversos nocivos, cuyos mecanismos moleculares subyacentes aún se desconocen, y es necesario seguir investigando para evaluar sus beneficios y su futuro uso en la investigación clínica.
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Cannabinoids in preclinical research of sepsis: a scoping review.
Cannabinoids are promising therapeutic targets in the treatment of sepsis, as they improved survival, and reduced inflammation and organ injury. However, deleterious adverse effects were reported, with the underlying molecular mechanisms still unknown, and further research is needed to evaluate their benefits and future use in clinical research.

https://link.springer.com/article/10.1007/s00011-025-02090-9

Foto por formulario PxHere.

07/11/2025

https://neurosciencenews.com/nano-tech-cbd-pain-29910/

A new study shows that CBD delivered through a nano-micelle system can cross the blood–brain barrier and produce rapid neuropathic pain relief.

28/10/2025

https://www.cannabistrades.org/stories/polyploid-and-triploid-cannabis-what-s-the-difference-and-why-does-it-matter

Every living thing, from humans to plants, has chromosomes, tiny packages of DNA that carry genetic information. The number of chromosome sets a plant has is described by the term ploidy.

02/10/2025

Psilocybin Rewire Brain Circuits Tied to Pain and Mood

Researchers have shown that psilocybin, the psychedelic compound in mushrooms, can relieve chronic pain and depression-like symptoms by targeting brain circuits rather than the site of injury.

In mice, a single dose eased suffering for nearly two weeks by modulating serotonin activity in the anterior cingulate cortex.

Unlike opioids, psilocybin worked like a “dimmer switch,” finely tuning signals rather than shutting them off completely.

The findings point to a promising new class of non-addictive treatments for chronic pain and mood disorders.

23/09/2025

https://medicalxpress.com/news/2025-09-body-endocannabinoid-receptor-result-neuropsychiatric.html

Endocannabinoids are similar to the cannabinoids present in cannabis, but they are found naturally in the body. Endocannabinoids—and cannabinoids—work through a signaling system that supports neurodevelopment, but whether manipulating this system prenatally has long-lasting effects remains uncle...