Ajolote Azul

21/01/2026

México tiene todo para convertirse en un líder mundial en el cultivo de cáñamo 🌾 Su ubicación geográfica privilegiada, la diversidad de climas, la calidad de sus suelos y, sobre todo, su profunda tradición agrícola, representan una ventaja competitiva real frente a muchos otros países.

El cáñamo industrial es una materia prima renovable y sustentable con aplicaciones en biocombustibles, textiles, bioplásticos, materiales de construcción, alimentos, suplementos y más. Una sola planta con decenas de industrias posibles.

Una regulación clara y bien diseñada podría detonar miles de empleos, atraer inversión, fortalecer economías rurales y reivindicar al campesino mexicano, que durante generaciones ha cultivado la planta y que, en muchos casos, ha sido criminalizado, desplazado o perseguido por políticas prohibicionistas y por el crimen organizado.

Regular el cáñamo no es promover el consumo, es apostar por el desarrollo económico, la sostenibilidad y la justicia social. México no necesita inventar nada nuevo, necesita reglas claras para transformar un potencial histórico en una oportunidad de futuro.

🌱 Necesitamos una regulación inteligente, técnica y con visión de largo plazo.

21/01/2026

https://www.facebook.com/share/p/17mKPuQXPd/

Unmetabolised Folic Acid (UMFA): The Hidden Risk Behind “Standard” Folic Acid

A NeuroThrive evidence-based guide

Folate (vitamin B9) is essential for life. It supports DNA synthesis, red blood cell production, methylation, and healthy neurological development. Because of its role in preventing neural tube defects, folic acid has been added to foods and supplements worldwide.

But here’s the problem most people are never told:

👉 Folic acid is not a natural vitamin.
👉 Many people cannot process it efficiently.
👉 Excess folic acid can remain unmetabolised in the bloodstream.

This inactive form is known as unmetabolised folic acid (UMFA) — and growing evidence suggests it may interfere with health in certain individuals.

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Folic Acid vs Folate: Not the Same Thing
• Folate: the natural form of vitamin B9 found in food (leafy greens, legumes, liver).
• Folic acid: a fully oxidised, synthetic compound used in fortified foods and most low-cost supplements.

Before folic acid can be used by the body, it must be converted in the liver by an enzyme called dihydrofolate reductase (DHFR) into active folate (5-MTHF).

Human DHFR activity is slow and highly variable.
When intake exceeds this conversion capacity, folic acid remains unmetabolised and enters circulation as UMFA.

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What Is Unmetabolised Folic Acid (UMFA)?

UMFA is inactive folic acid circulating in the blood.
It does not participate in methylation or DNA synthesis and may interfere with normal folate metabolism.

Large population studies show UMFA is now common in fortified countries, even at standard supplement doses.

In simple terms:

You can be “taking folate” but still be functionally folate-deficient at a cellular level.

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Why UMFA May Be Harmful: What the Science Shows

This is not fear-mongering. It’s about biochemistry, dose, and individual genetics.

1. UMFA May Block Active Folate Uptake

UMFA appears to compete with natural folates and 5-MTHF for folate receptors and transporters.

This means:
• Less active folate enters cells
• Methylation may remain impaired
• Homocysteine clearance may be sub-optimal

This is especially relevant for people with MTHFR gene variants, where methylation efficiency is already reduced.

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2. UMFA and Immune Suppression

Multiple human studies have linked detectable UMFA levels with reduced natural killer (NK) cell cytotoxicity — a key component of immune surveillance.

NK cells play a role in:
• Viral defence
• Tumour surveillance
• Immune balance

While outcome-level disease risk is still being studied, the signal is consistent enough to raise concern around chronic high folic acid exposure.

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3. Masking and Potentially Worsening Vitamin B12 Deficiency

This is the most established risk of excess folic acid.

High folic acid intake can:
• Correct anaemia caused by B12 deficiency
• Hide the deficiency on blood tests
• Allow neurological damage to progress unnoticed

Emerging evidence suggests folic acid may also exacerbate neurological injury in B12 deficiency, particularly in older adults.

This is critical because B12 deficiency can cause:
• Neuropathy
• Cognitive decline
• Balance problems
• Psychiatric symptoms

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4. Pregnancy, Neurodevelopment, and Excess Exposure

Adequate folate before and during early pregnancy is essential — this is not disputed.

However, research has raised questions about:
• Very high folic acid intake
• UMFA levels in maternal and cord blood
• Possible associations with altered neurodevelopmental outcomes

The science here is complex and evolving, but the takeaway is clear:

More is not always better. Correct form and dose matter.

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Who Is Most at Risk of UMFA Accumulation?

You may be more vulnerable if you:
• Consume fortified foods daily plus supplements
• Take high-dose folic acid (≥1 mg/day) long-term
• Have an MTHFR gene variant
• Have low or borderline vitamin B12
• Are older, vegan/vegetarian, or on metformin or PPIs

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A Smarter, Science-Led Approach to Folate

At NeuroThrive, we believe in precision nutrition — not blanket supplementation.

Evidence-aligned guidance:
• 🥬 Food first: natural folate from whole foods
• ❌ Avoid unnecessary high-dose folic acid
• 🧬 Consider 5-MTHF (methylfolate) — the biologically active form
• 🧠 Always support folate with adequate vitamin B12
• 🩸 Monitor homocysteine, not just “serum folate”

This approach supports methylation without creating UMFA.

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The NeuroThrive Perspective

We don’t believe folic acid is “evil.”
We believe biochemistry is personal.

For many people — especially those with methylation issues — switching from folic acid to bioactive folate is not a trend. It’s common sense.

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References (selected, peer-reviewed)
• Bailey, S. W. Human dihydrofolate reductase: slow and variable activity.
• Pfeiffer, C. M. et al. (2015). Unmetabolized folic acid is detected in nearly all serum samples in fortified populations. Am J Clin Nutr.
• Troen, A. M. et al. (2006). UMFA associated with reduced NK cell cytotoxicity. PNAS.
• Sawaengsri, H. et al. (2016). UMFA and immune function in humans.
• Paniz, C. et al. (2017). High-dose folic acid increases UMFA and reduces NK activity.
• Miller, J. W. (2024). Excess folic acid and vitamin B12 deficiency: neurological implications.
• UK Committee on Toxicity (COT). Folic acid and masking of B12 deficiency.
• Husebye, E. S. N. et al. (2022). UMFA in pregnancy: a review.

11/12/2025

27/07/2025

Could psilocybin could become a monthly neurotropic at high doses and/or a near-daily neurotropic vitamin at low doses? So exciting for this to be further explored. Will the U.S. government fund research? I hope so! Read more about this study: https://www.nature.com/articles/s41514-025-00244-x.epdf?sharing_token=Q0ZZYUlHmeSnrFjGz2S1Q9RgN0jAjWel9jnR3ZoTv0PyRv5iaSQQ2PWA7_FlthLNvoQwwb75DA84SBPFAv3EJ2kPOzYnH5UVjRm_VUO7mu9BYL1OtN2dPM7GWuhRiHtZQLyCJIaRICnF0XPP2S8QlZlXcdKa-V4x89tLjKsfU_w%3D

09/10/2024

Ideally, depending per individuals preferences, we initiate ice baths 2-5 times a week, with a separate sauna schedule.

By reducing muscle soreness and inflammation, ice baths can significantly speed up your recovery after intense workouts.

They enhance athletic performance by improving central nervous system function and reducing fatigue, allowing you to train harder and recover faster.

Not only do ice baths boost your mood and mental health by triggering the release of endorphins, but they also help you feel more alert and less stressed.

Regular cold exposure supports your immune system, potentially increasing white blood cell counts to help fight off illness.

Additionally, ice baths can improve your sleep quality by lowering your body temperature before bedtime, making it easier to drift into a restful night. They activate brown fat tissue, which supports metabolic health and aids in weight management through calorie burning.

Finally, cold water immersion enhances circulation as your body works to maintain its core temperature, promoting cardiovascular health and detoxification.

"C-Reactive Protein (CRP): Cold water immersion has been shown to significantly decrease CRP levels, a common marker of inflammation in the body. Elevated CRP levels are often associated with chronic inflammatory conditions and can indicate increased risk for various diseases, including cancer.

Interleukin-1 Beta (IL-1β): Research indicates that ice baths can lower levels of IL-1β, a pro-inflammatory cytokine that promotes inflammation and is often elevated in cancer and other inflammatory diseases.

Tumor Necrosis Factor-alpha (TNF-α): Some studies suggest that cold exposure can lead to increased levels of TNF-α, which plays a role in systemic inflammation. However, the overall impact on inflammation may vary depending on individual circumstances and specific conditions.

Erythrocyte Sedimentation Rate (ESR): This test measures how quickly red blood cells settle at the bottom of a test tube. A faster-than-normal rate can indicate inflammation. While direct evidence linking ice baths to reduced ESR is less clear, cold exposure is known to affect overall inflammatory responses

Alpha-1 Antitrypsin: Cold exposure may decrease levels of this protein, which is associated with inflammation and tissue damage."

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2211456/

09/10/2024

The biggest advantage of our location is that we have direct access to open ocean waters.

The minerals in seawater help detoxify the body, facilitating the removal of toxins that can accumulate during cancer treatments.

More so, the ocean provides significant relaxation, which can help alleviate stress and anxiety often experienced by patients. This mental well-being is crucial during the search of peace and acceptance.

09/10/2024

Early mornings start with easy movements and stretching, continuing with an aerobic exercise, ideally running.

Later in the day if swimming is not an option, depending of ocean activity, we procced with weight lifting to promote bone density, muscle growth and blood flow.

09/10/2024

The Ajolote Azul Cancer Program, designed with a holistic approach built on Four Common Sense Pillars and a strong Roof of Immunity.
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The Four Pillars of Our Approach:
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1. Nutrition: We emphasize the importance of a balanced diet precision tailored to support your treatment and needs. With the use of a our Nutrigenetic test, we work closely with you to create personalized meal plans and adequate supplement use, to address possible deficiencies, enhance health and create the building blocks for fast recovery.
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2. Exercise: Regular physical activity is crucial for maintaining strength , lower inflammation, promote cardiovascular health and improve overall mood on a daily basis. We provide customized exercise programs that cater to your individual motor capabilities, preferences and necessities.
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3. Activities: Engaging in meaningful activities can significantly enhance emotional support and quality of life. We offer various programs, including art therapy and support groups, to help you connect with others and share experiences.
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4. Sleep: Quality sleep is essential for healing. Our team provides resources and strategies to monitor and improve your sleep patterns, ensuring you receive the restorative rest necessary for constant energy levels, focused and sharp mind.
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The Roof: Immunity:
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At the top of our program is the Immunity, which is vital for fighting cancer and achieving homeostasis from treatments. By vigorously integrating all four pillars, we aim to enhance your immune function and regenerative capability that gradually will better the response against disease.
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Education Throughout Recovery
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We are committed to educating participants throughout their recovery process. Our program spans from 3 to 6 months, during which we provide ongoing support and education to help you understand your treatment options and make informed decisions about your health. "The Why's and How's".
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Incorporating Natural Medicine
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In addition to conventional treatments, we also utilize natural medicine, including cannabis and psilocybin, as part of our comprehensive care approach. These therapies can complement traditional treatments by helping manage symptoms and improve overall well-being, providing excellent anti-inflammatory and anti-tumoral qualities.
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Join us in building a strong foundation for your health and well-being. Your journey matters, and we are here to support you every step of the way!
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After doing your due diligence please contact us directly so we can procced with the formalities of first contact via our form. Thank you.

09/10/2024

"Almost 14% of colorectal tumor malignancies in the population are ascribed to a physically inactive lifestyle [16]. Most studies have observed a 70% reduction in the risk of colon cancer in individuals with higher levels of physical activity"

"Exercise and Breast Cancer Exercise has been shown to reduce the risk of breast cancer by 30–40% in women with increased physical activity and even a dose–response relationship has been found in menopausal women"

"Moderate aerobic exercise five times a week combined with daily physical activity has reduced risk by 50–75% in postmenopausal women [81]. Aerobic exercise can also be beneficial for both the prevention and therapy of the cardiotoxicity impacts of doxorubicin and trastuzumab, promoting cardiorespiratory capability"

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10648074/

09/10/2024

The main exercise integrated in the program is swimming.

Each individual has the responsibility to complete a minimum of 1 hour swim or 1km distance daily.

It is well known that this stands as the most well rounded physical activity, without putting pressure on the joints of the participant, while directly helping with injury prevention and recovery.

09/10/2024

Sleep is critically important in cancer care, enhancing recovery and treatment efficacy.

Quality sleep improves pain tolerance and boosts remission rates, allowing the body to better combat disease and respond to therapies. It regulates key hormones like cortisol and melatonin, vital for immune function and cell growth.

Adequate rest also enhances the effectiveness of treatments aligned with the body’s circadian rhythms.

Additionally, good sleep supports mental well-being, reducing anxiety and depression often experienced by patients. Prioritizing sleep is essential for improving recovery, treatment outcomes, and overall quality of life for those affected.

09/10/2024

Tailored interventions that consider the unique genetic, biological, and lifestyle factors of each patient to optimize treatment effectiveness. These approaches aim to enhance patient outcomes by integrating individualized regimens, and psychological support, ultimately improving both physical health and quality of life during cancer care.