PGS Malaysia

23/06/2025

PGT-A / PGS in Malaysia - Risky, Unnecessary and Wasteful?
Preimplantation Genetic Testing - Aneuploidy (PGT-A), also known as Preimplantation Genetic Screening (PGS), is broadly applied to the majority of IVF patients in Malaysia. However, this may be risky, unnecessary and wasteful.

Preimplantation Genetic Testing - Aneuploidy (PGT-A), also known as Preimplantation Genetic Screening (PGS), is broadly applied to the majority of IVF patients in Malaysia. However, this may be risky, unnecessary and wasteful.

31/03/2023

Why Assessing Genetic Normality Of IVF Embryos By AI Is A Better Option

It might be preferable for older women undergoing IVF to screen their embryos for genetic abnormalities, before transferring them into their wombs.

31/03/2023

Clinical trial shows that PGS / PGT-A reduces live birth rates in IVF

Following neutral results in several high profile RCTs, PGT-A has once again failed to demonstrate its benefit in terms of LBR, now in a new cohort analysis from the SART database. Can the results be explained by mosaicism in some embryos, misdiagnosis, or biopsy?

21/03/2023

Prominent Doctors and Scientists Criticize Continued Utilization of Preimplantation Genetic Testing for Aneuploidy (PGT-A) in IVF and Warn about a New Fourth Generation Test

January 12, 2021 -- While biological ability of human embryos to self-correct genetic abnormalities renders PGT-A fundamentally useless, more and more IVF centers push the costly test on already cost-burdened fertility patients

21/03/2023

New research casts fresh doubt on a common procedure that promises to increase the odds of IVF

New research casts further doubt on a common — and controversial —procedure that promises to increase the odds of IVF.

14/03/2023

Malaysia needs stricter regulation of the genetic testing of embryos

Photo: EVGENIY SALOV/Dreamstime/Tribune News Service DOWN syndrome is the most common genetic abnormality in newborns, and it is caused by the presence of an additional chromosome 21. As World Down Syndrome day approaches on March 21, we are reminded of the sobering statistic that around 90% of Down...

12/07/2022

Why Assessing Genetic Normality Of IVF Embryos By AI Is A Better Option

It might be preferable for older women undergoing IVF to screen their embryos for genetic abnormalities, before transferring them into their wombs.

05/07/2022

Genetic testing controversy clouds medical tourism in Malaysia

Wealthy couples from Singapore and China are flocking to Malaysia for IVF genetic testing

19/11/2021

Cost-effectiveness of doing genetic testing of IVF embryos ( PGS / PGT-A ) to prevent Down syndrome and other genetic abnormalities in older mothers

Currently, there is an increasing trend of late motherhood in Singapore and many other countries throughout the world, as rising numbers of better-educated women choose to postpone marriage and childbearing in pursuit of career development. Nevertheless, there are heightened risks of conceiving a ba...

14/10/2021

Genetic Testing Of IVF Embryos Overseas: What Singaporean Patients Should Know

Singaporean patients traveling abroad for IVF treatment should be cautious not to be ‘pushed’ into undertaking PGS unnecessarily. The post Genetic Testing Of IVF Embryos Overseas: What Singaporean Patients Should Know appeared first on theAsianparent - Your Guide to Pregnancy, Baby & Raising Kid...

14/10/2021

IVF genetic testing to prevent birth defects in older women https://www.biospectrumasia.com/opinion/54/19177/ivf-genetic-testing-to-prevent-birth-defects-in-older-women.html?fbclid=IwAR13Ka9CszB9YHWFMZMav-W_EJJcTpoY-CrwTTDcmBy7upyNmpbsBRvXBKU

In conversation with Dr. Alexis Heng Boon Chin, Associate Professor, Peking University, China

19/02/2021

Abnormal embryos diagnosed by PGS / PGT-A can give rise to normal healthy births. PGS maybe unnecessary and a waste of money!

Please take note of the controversy surrounding PGS with regards to Mosaic embryos, which have a mixture of normal (euploid) and abnormal (aneuploid) cells. These are often tested to be genetically abnormal by PGS, but in fact can give rise to normal healthy births.
As seen in the attached diagram of a blastocyst-stage human embryo, the ICM gives rise to the embryo, while the TE gives rise to the placenta and yolk sac. Testing a few cells from the TE only gives you a probability about what's going on in the ICM. An embryo with abnormal (aneuploid) TE but normal ICM most likely will still make a healthy baby.
Hence, by discarding such mosaic embryos that are tested abnormal during PGS, one would lower the cumulative chances of IVF success.