
04/10/2022
Stroke remain a condition with high morbidity and mortality. Stroke happens as a result of insufficient blood and oxygen supply to the brain. 3 main types of stroke are artery rupture (hemorrhagic), blood clot blockage (embolism) and plaque obstruction (atherosclerosis).
Rupture of blood vessel causes blood to accumulate in brain, which compress brain tissue and cause damage. Thereafter, inflammation occurs. The biochemicals released from the damaged blood vessel and inflammation process further damage brain tissue.
In atherosclerosis, plaque form in the blood vessel, either plaque buildup completely obstruct blood vessel, or the thin fibrous cap of plaque rupture and cause blood clot that completely block the blood vessel. Either way, blood vessel will be obstructed and therefore cannot deliver oxygen to the brain tissue. Brain tissue that couldn't get oxygen will die. When brain tissue die, they release biochemicals that will further damage the brain tissue.
For embolism, bloot clot that form elsewhere travels to the blood vessel that supplies the brain and obstruct the vessel. This also causes brain tissue to be deprived from oxygen and die.
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