Stem Cell Therapy Malaysia

02/09/2025

We may have a cure for diabetes.

A patient with type 1 diabetes is now producing his own insulin after receiving a groundbreaking transplant of gene-edited pancreatic cells, without needing any anti-rejection drugs.

This is the first time in humans that donor islet cells have been genetically modified to evade the immune system entirely. Type 1 diabetes is caused when a person’s immune system mistakenly attacks the islet cells in their pancreas, which are responsible for insulin production.

Treatments typically involve lifelong insulin injections and, in rare cases, transplants, though these usually require immunosuppressants, which carry serious long-term risks. In this new case, a 42-year-old man who had lived with type 1 diabetes since childhood received injections of donor islet cells into his forearm. But before that, scientists made three specific edits using CRISPR: two removed cellular markers that help T cells recognize foreign tissue, and one added a protein called CD47, which helps block the body's innate immune responses.

The results were dramatic. Over 12 weeks, the edited cells began producing insulin in response to glucose spikes, like after meals. The man didn’t need any immunosuppressive medication to keep the cells alive. Not all the edited cells survived, only those with all three edits remained functional, which gave researchers a built-in comparison and proof that their editing approach worked. While the patient didn’t receive enough cells to fully manage his condition without additional treatment, the experiment shows that functional, gene-edited cell transplants can survive and work in the human body without being attacked by the immune system.

paper
"Survival of Transplanted Allogeneic Beta Cells with No Immunosuppression" New England Journal of Med. (2025)

01/09/2025

🧠 Scientists may have just found the “off switch” for brain aging.

A groundbreaking study from the University of California, San Francisco has identified a single protein—FTL1—that appears to drive cognitive decline with age.

Researchers found that elevated FTL1 levels slow brain activity, weaken neural connections, and impair memory. Young mice engineered to produce more of the protein began to show aging-like symptoms, while older mice in which FTL1 was reduced regained memory function and stronger neural pathways in the hippocampus—the brain’s memory hub.

Even more striking, the work suggests aging in the brain may not only be slowed but reversed at the molecular level. FTL1 also disrupts cellular metabolism, further accelerating brain aging, meaning therapies that target this protein could provide a new strategy against dementia and Alzheimer’s disease.

As senior author Dr. Saul Villeda explains: “We’re talking about a real reversal.”

This discovery could reshape the future of neurodegenerative treatment, offering the possibility of restoring youthful brain function in aging populations.

01/09/2025

👂✨ Born Deaf — Now Hearing the World, Thanks to Gene Therapy!

In a groundbreaking clinical trial, scientists have restored hearing in children born completely deaf — by repairing a single faulty gene (OTOF) using viral gene therapy.

🔬 The OTOF gene is crucial for sending sound signals from the ear to the brain. When it’s defective, the result is lifelong silence.

But now, using a modified virus to deliver a healthy version of this gene directly into the inner ear, researchers were able to partially or fully restore hearing — and one child began hearing within weeks!

👶 This marks the first time gene therapy has reversed congenital deafness in humans — and it could change the lives of millions affected by genetic hearing loss.

The trial, conducted in China, used a dual-vector AAV system to overcome the gene’s large size — a technical feat that may now pave the way for treating many other genetic conditions.

The future of hearing is here — and it’s coded in our DNA.

30/08/2025

Bendera berkibar megah di angkasa,
Jalur Gemilang lambang negara,
Merdeka 2025 penuh makna,
Cinta Malaysia selamanya.

29/08/2025

28/08/2025

The calf muscles—especially the soleus and gastrocnemius—function as a “second heart” by helping push blood from the legs back toward the heart.

When they contract, the veins are compressed, and one‑way valves ensure blood moves upward. This action supports venous return and prevents blood from pooling in the lower extremities.

If activity is limited, the calf pump weakens, increasing risks of DVT, varicose veins, and chronic venous issues.

Because the soleus muscle is well-suited for endurance, it is particularly effective at sustaining the pump over time.

Strengthening and stretching the calves—via exercises like calf raises and calf stretches—enhances their function, helping maintain healthy circulation, reduce blood pressure, and protect against clot formation.

25/08/2025

Scientists have discovered a molecule called SCUBE3 that shows promising potential to reverse baldness by reactivating dormant hair follicles.

This discovery comes from a 2022 study by researchers at the University of California, Irvine, who demonstrated that SCUBE3—a signaling protein naturally produced by dermal papilla cells at the base of hair follicles—can effectively stimulate hair growth.

In lab tests, when SCUBE3 was injected into mice, both mouse and transplanted human hair follicles that were previously inactive began producing new hair.

This confirms that the molecule plays a direct role in kickstarting the hair growth cycle, specifically by pushing follicles into the active (anagen) phase.

The findings are especially significant for people suffering from androgenetic alopecia, the most common form of hair loss.

Unlike treatments that only slow hair loss, SCUBE3 directly targets the reactivation of the body's existing hair growth systems.

The molecule appears to act as a messenger that tells nearby hair follicles it's time to grow again.

The results have been consistent across different models, making SCUBE3 a strong candidate for a future baldness therapy.

24/08/2025

New research reveals a startling reason why men may be more prone to heart disease than women. Scientists have found that as men age, they can lose their Y chromosome in a significant number of immune cells, a condition called mosaic loss of Y. This loss appears to increase the risk of narrowed blood vessels, a major contributor to cardiovascular disease.

The study, which involved over 30,000 participants, shows that losing the Y chromosome impairs immune function and triggers inflammation, gradually damaging blood vessels over time. Experts say this chromosomal instability may help explain the shorter average lifespan of men compared to women. Kenneth Walsh from the University of Virginia called the findings alarming, highlighting the potential impact of s*x chromosome loss on male health.

Understanding mosaic loss of Y opens new possibilities for protecting men’s heart health. Researchers hope this discovery could lead to screening methods that identify men at higher risk or even treatments that counteract the harmful effects of Y chromosome loss. As science uncovers the role of chromosomes in disease, this breakthrough could help tackle one of the leading causes of death in men worldwide.

The study underscores the importance of genetic research in understanding age-related health risks and could be a turning point in preventing cardiovascular disease in men as they grow older.

22/08/2025

What you might be referring to as an “or**sm chair” is most likely the BTL Emsella® chair—a medical treatment chair that’s sometimes nicknamed this due to its ability to help improve intimate wellness, including or****ic ability, by strengthening pelvic floor muscles via focused electromagnetic stimulation. It does not directly induce or**sm, but rather enhances your pelvic muscle function, which can indirectly support improved s*xual experiences. Here’s a look at its safety and effectiveness:

What Is the Emsella (“Orgasm”) Chair?
• The Emsella chair uses High-Intensity Focused Electromagnetic (HIFEM) technology to stimulate pelvic floor muscles through thousands of supramaximal contractions—much more than you can achieve with voluntary Kegels.  
• You remain fully clothed and simply sit in the chair for about 30 minutes per session.  
• Treatment typically involves multiple sessions (often six, twice a week), tailored per individual.  

Safety & Side Effects

Safety Profile:
• The Emsella chair is non-invasive, FDA-cleared, and CE-marked, with no known serious side effects.  
• It’s considered pain-free, with most users reporting only a light tingling or muscle contraction sensation.  
• There’s no downtime—you can resume normal activities immediately after treatment.  

Possible Mild Side Effects:
• Temporary sensations like warmth, tingling, or slight muscle soreness in the pelvic area.  
• Some may experience muscle spasms, redness, frequent urination, or even mild dizziness or nausea, typically resolving within a couple of days. 

Precautions:
• Not suitable for individuals with electronic implants (e.g., pacemakers, cochlear implants), pregnancy, or certain health conditions like heart disease, cancer, hypertension, or neurological disorders. Always inform your provider.  
• Metal accessories (e.g., jewelry, piercings) should be removed before treatment. 

What It’s Used For & Effectiveness
• Stress urinary incontinence (SUI): Studies report up to 95% improvement and 75% reduction in pad use. 
• Sexual function: By strengthening pelvic floor muscles, many users report enhanced s*xual satisfaction and improved or**sm ability.  
• Everyday functionality: Beneficial post-pregnancy, during menopause, or for pelvic health in men as well.   

Summary: Is It Safe?
• Yes, generally regarded as safe when recommended by a qualified provider and used according to guidelines.
• Low-risk, high-convenience: No invasive procedures, no discomfort, and no downtime.
• Minor side effects may include temporary tingling or muscle soreness.
• Not for everyone—consult your doctor if you have contraindications like implants, certain medical conditions, or if you’re pregnant.
• Effectiveness: Backed by clinical evidence for incontinence and showing promise for enhancing intimate wellness.

Final Thoughts

The Emsella (“or**sm”) chair is a legitimate, clinically backed treatment aimed at improving pelvic floor health—not a device that “triggers or**sm.” If you are considering it, it’s wise to first consult a pelvic health specialist or trained clinician to ensure it’s appropriate for your needs and physical condition.

21/08/2025

German scientists have unveiled a revolutionary injectable gel that can regrow cartilage in damaged joints, offering a potential end to many knee and hip replacement surgeries. This bioactive hydrogel is loaded with growth factors, collagen fibres, and stem cell attractants, creating the perfect environment for natural cartilage repair.

Once injected into a worn joint, the gel forms a flexible scaffold that mimics real cartilage. It recruits the body’s own stem cells, triggering layer-by-layer regrowth of cartilage while adapting to movement and becoming stronger over time. In clinical trials, patients with severe osteoarthritis showed visible cartilage regeneration within just 60 days, along with significant pain relief and improved mobility.

Unlike traditional implants, this gel does not require surgery, has no risk of long-term wear or rejection, and even reduces inflammation without the need for post-operative medication. It naturally biodegrades once healing is complete, leaving behind healthy, functional joint tissue.

The treatment could be life-changing for millions, especially younger patients and athletes seeking non-invasive recovery options. With regulatory approval in Europe expected soon, Germany plans to make this breakthrough therapy available in clinics by 2026. Experts say this could mark the beginning of a new era in orthopaedic medicine, replacing artificial joints with the body’s own natural healing power.

20/08/2025

A new study has sparked concern for men’s reproductive health, revealing that keeping mobile phones in your pocket or using laptops directly on your lap could quietly affect s***m quality. Researchers found that prolonged exposure to radiofrequency electromagnetic radiation (RF-EMR) from these devices may lower s***m count, reduce motility, and even damage DNA integrity.

The heat generated by laptops and smartphones can also play a role. Testicular temperature that rises above the optimal range can disrupt normal s***m production, leading to decreased fertility potential. In particular, s***m cells are highly sensitive to both heat and oxidative stress, making daily habits like pocket storage or lap use riskier than many realize.

RF-EMR exposure is being studied worldwide for its biological effects, and while more research is needed, early evidence suggests a connection between device placement and reproductive harm. The closer the source of radiation and heat is to the reproductive organs, the greater the potential impact.

Experts recommend simple preventive measures: keep your phone in a bag or on a desk instead of your pocket, use a laptop stand or desk rather than resting it on your lap, and take regular breaks from close-contact device use.

Protecting fertility may come down to small changes in daily tech habits that reduce unnecessary exposure while still allowing the convenience of modern devices.