18/08/2025
[Patient Story] [Hongkong – Lung Cancer – Cryoablation]
Hong Kong Woman with Advanced Lung Cancer; Father, Brother, and Sister Also Diagnosed with Lung Nodules or Lung Cancer
This story begins with two sisters from Hong Kong.
In December 2022, the elder sister, Xiao (pseudonym), began experiencing headaches. Initially, she thought it was trigeminal neuralgia caused by periodontal disease, but repeated examinations found nothing abnormal. However, as her headaches and chest pains worsened, she underwent a chest CT scan at a local hospital, which revealed a 4.7 × 4.7 cm mass in the right upper lung near the hilum. She was eventually diagnosed with right lung adenocarcinoma, with multiple metastases to lymph nodes, bones, liver, lungs, and brain.
Genetic testing revealed an EGFR exon 19 deletion mutation, so Xiao began taking oral targeted therapy and received whole-brain radiotherapy along with local intensity-modulated therapy. However, she soon developed drug resistance. Despite multiple changes in medication and treatment adjustments, her cancer continued to progress, leaving local doctors at a loss. Xiao suffered immensely—she was unable to walk, her bones and thighs were immobile, and she relied entirely on a wheelchair. The level of pain she endured was described as “10 out of 10.”
Later, Xiao learned about cryoablation technology from an American friend and read news reports about Fuda Cancer Hospital in Guangzhou. Hoping to relieve her suffering, Xiao and her younger sister, Xia, went together to Fuda’s Medical Department One on March 30 of this year to seek treatment.
Based on admission examinations and her medical history, and in order to control the tumor locally and reduce tumor burden, the team at Medical Department One performed cryoablation to control the tumor in her right lung, combined with anti-angiogenic targeted therapy and intra-arterial infusion chemotherapy, allowing small doses of drugs to directly reach the tumor.
“Whether it’s interventional therapy or cryoablation, there’s no obvious discomfort. Targeted therapy feels just like a glucose infusion—you just lie in bed or walk around with this ‘Christmas tree IV stand.’” After each treatment, doctors provided liver- and kidney-protective care to reduce side effects. Compared with before, Xiao’s CT scans showed the tumor had shrunk.
△ Assistant to the President and Deputy Director of Medical Department One, Long Xin’an, with attending physician Li Chunli, leading ward rounds
Xia, her younger sister, was not only a companion during the treatment but also a patient herself. Two years earlier, she had been found to have a lung nodule. At that time, the nodule was small, so only regular follow-ups were needed. Over time, however, it grew into a 0.7 cm ground-glass nodule. This year’s chest CT revealed multiple ground-glass nodules in both lungs, the largest located in the anterior basal segment of the right lower lobe—classified as intermediate risk.
Recalling that their father had died of lung cancer, and that among eight siblings, one sister had lung cancer and both she and her younger brother had lung nodules, Xia became determined to address her worrying lung nodule. She underwent cryoablation at Fuda Hospital. Fortunately, postoperative pathology confirmed it was benign.
“It was our own prejudice,” said their younger brother, Mr. Xu, who had come along specifically to see for himself whether the Fuda Hospital so highly praised by his sisters truly lived up to its reputation. Within just a few days, he had become an ardent supporter. Holding the hospital’s brochure in his hands, he flipped through it page by page, commenting on each section with visible admiration.
△ Younger brother Mr. Xu reviewing the hospital’s promotional materials
“Many of these techniques are not yet available in Hong Kong.” Before coming to Fuda, he thought medical treatments around the world were largely the same. But upon arriving, he felt as though he had stepped into a whole new world. He was particularly interested in Fuda’s unique “3C+P” treatment model—especially after witnessing his sister’s tangible improvement under this approach. “When my sister first arrived, every step caused pain and she needed a wheelchair. Now she can walk around with a cane, take care of herself, and has even gained over 10 pounds.”
In addition to advanced medical technologies, what impressed them most was Fuda’s exceptional service and comfortable medical environment. “During ward rounds, the medical staff enter in an orderly manner like a disciplined team, asking questions in detail. The nurses are practically on call around the clock.” The siblings also noticed that Fuda’s patients come from all over the world, and the hospital provides special facilities for international patients, such as a Buddhist hall, prayer room, and halal room. “In Hong Kong, even if you have money, it’s hard to enjoy this level of service because hospital beds are in such short supply.” Xiao still requires ongoing treatment, but each return trip to Fuda now feels like a journey—and she believes she will grow stronger along the way.
Did You Know? — Can Lung Cancer Be Inherited?
Lung cancer is not directly inherited, but genetic factors may increase an individual’s risk. This risk is most apparent in family clusters of the disease. If several family members across multiple generations have had lung cancer, certain genetic mutations or chromosomal abnormalities may be present, increasing the likelihood for descendants to develop the disease.
Research shows that first-degree relatives of lung cancer patients have more than double the risk compared to the general population. However, lung cancer develops as a result of multiple factors combined, including smoking, air pollution, occupational exposures, and chronic lung disease. Genetic predisposition is only one factor—it is not decisive.
Therefore, people with a long history of smoking, exposure to secondhand smoke or cooking oil fumes, long-term occupational exposure to radon, arsenic, beryllium, or their compounds, a family history of lung cancer, or chronic lung disease—especially those over the age of 40—are advised to undergo regular lung cancer screenings such as low-dose spiral CT, in order to detect potential early-stage lesions and improve survival rates.
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【患者故事】【香港-肺癌-冷冻+介入】
一家四口接連患肺癌，疑與家族遗傳相關
故事要由香港兩姐妹講起。
2022年12月，家姐阿霄（化名）出現頭痛症狀，最初以為係牙周病影響咗三叉神經，但多次檢查都搵唔到異常。不過，隨住頭痛同胸痛越嚟越嚴重，她去當地醫院做咗胸部CT檢查，發現右上肺近肺門位置有一個大約4.7×4.7厘米嘅腫塊，最終確診為右肺腺癌，並且伴隨淋巴結、骨骼、肝臟、肺部同腦部多處轉移。
因為基因檢測發現佢有EGFR第19號外顯子缺失，阿霄開始口服靶向藥，同步接受全腦放療同局部調強治療。但唔耐之後，阿霄就出現咗耐藥情況，雖然多次換藥、調整治療方案，腫瘤依然持續進展，本地醫生亦束手無策。當時嘅阿霄深受病痛折磨：行唔到路，骨頭同大髀完全郁唔到，只能依賴輪椅，痛楚程度堪稱十級劇痛。
後來，阿霄從一位美國朋友口中聽到「冷凍消融技術」，並且查閱咗廣州復大腫瘤醫院嘅相關報道。抱住減輕痛苦嘅希望，阿霄同細妹阿霞喺今年3月30日一齊嚟到復大醫療一科求醫。
結合入院檢查結果同既往病史，為咗局部控制腫瘤、降低腫瘤負荷，醫療一科團隊同姐妹倆詳細溝通後，為阿霄實施咗冷凍消融術局部控制右肺腫瘤，同時畀佢接受抗血管生成靶向治療，並聯合介入動脈灌注化療，令小劑量藥物直擊腫瘤內部。
「無論係介入定係冷凍治療，都冇明顯嘅唔舒服感。靶向治療時，感覺好似打葡萄糖咁，只要訓喺張床度，或者拖住呢個『聖誕樹吊架』周圍行。」每次治療之後，醫生都會幫佢做護肝、護腎等處理，減少副作用。相比之前，阿霄嘅CT影像顯示病灶明顯縮細。
△院長助理、醫療一科副主任龍新安，主管醫生李春麗帶隊查房
而喺呢度嘅治療，細妹阿霞唔淨止係陪診者，仲係親身經歷者。兩年前，佢被發現有肺結節，因為當時結節細，只需定期覆檢。不過，隨住時間過去，結節慢慢長到0.7厘米嘅磨玻璃樣結節。特別係今年，胸部CT檢查顯示雙肺多發磨玻璃結節，其中最大嘅位於右肺下葉前基底段，屬於中危。
諗起爸爸因肺癌離世，而自己八兄妹之中，家姐患肺癌，細妹同阿弟都查出肺結節，阿霞迫切希望處理呢個令人不安嘅結節。最終，她喺復大醫院接受咗冷凍消融術。幸好，術後病理結果顯示係良性。
「係我哋有偏見。」阿弟許生今次專登陪兩位姐姐嚟，就係想親眼睇吓嗰間被姐姐們屢次稱讚嘅復大醫院，係咪真係名副其實。然而，只係短短幾日，佢就變成咗復大嘅忠實粉絲。佢手捧住醫院嘅宣傳冊，一頁頁仔細翻，逐處認真評論，滿滿嘅仰慕之情溢於言表。
△弟弟許生拎住醫院宣傳資料逐處評論
「好多技術而家香港仲未有。」嚟復大之前，弟弟一直以為全球嘅治療方式都差唔多，但踏入復大之後，佢好似打開咗一扇新世界嘅大門。除咗滿心感激之外，佢對復大獨特嘅「3C+P」治療模式好感興趣。特別係親眼見到家姐喺呢種治療模式幫助之下，病情真係改善咗。「我家姐以前一落地就痛，要靠輪椅，到而家可以自己拄拐杖周圍行，生活可以自理，體重仲重咗十幾磅。」
除咗先進嘅醫療技術，更令佢哋讚唔絕口嘅係復大醫院卓越嘅服務同舒適嘅就醫環境。「每次查房，醫護人員好似部隊咁有序入嚟，逐一細心問診。護士幾乎全天候在線服務。」阿霄兄妹三人仲發現，復大嘅病人來自世界各地，醫院仲為外籍患者提供專門嘅設施，例如佛堂、祈禱室、清真室等等。「喺香港，就算有錢，都好難享受到咁嘅待遇，因為床位極之緊張。」而家，阿霄仍需繼續治療，但每一次返院，她都當成一次旅行，並相信自己會喺呢段旅程中變得更好。
知識知多啲——肺癌會遺傳嗎？
肺癌唔係一種直接遺傳嘅疾病，但遺傳因素可能會增加個人患肺癌嘅風險。呢種風險主要表現為家族聚集性。如果家族中有多個或者多代人患肺癌，可能係因為體內有某啲遺傳基因或者染色體異常，增加後代患病嘅機會。
有研究顯示，肺癌患者嘅一級親屬患肺癌嘅風險比普通人高兩倍以上。不過，肺癌嘅發生係多種因素綜合作用嘅結果，包括吸煙、空氣污染、職業暴露、肺部慢性疾病等等。遺傳因素只係其中一部分，並唔係決定性因素。
所以，建議有長期吸煙史、二手煙暴露史、廚房油煙暴露史、氡、砷、鉍及其化合物長期職業暴露史、肺癌家族史，以及慢性肺部疾病史嘅人士，特別係40歲以上人群，應該定期進行肺癌篩查，例如低劑量螺旋CT，以期更早發現潛在早期病變，提高生存率。
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