18/01/2025
https://www.ncbi.nlm.nih.gov/books/NBK592402/ Epigenetic is the evironmental and nutritional factors can alter histones, leading to persistent changes that last a lifetime and can pass through paternal and maternal generations.
In utero exposure can cause epigenetic variations, such as gestational diabetes exposure resulting in methylated DNA changes that lead to multiple adiposity-related outcomes. This phenomenon was discovered through epigenome-wide association analysis, highlighting the crucial role of maternal health in obesity.
Obesogens are chemicals that can promote obesity by altering adipose tissue indirectly. These chemicals can impact metabolism, food calorie intake, and energy balance and may cause an altered set point leading to obesity later in life. Some environmental sources contain obesogens such as bisphenols, phthalates, parabens, nonsteroid estrogens, organotins, and polychlorinated biphenyls.