One Day MD

09/05/2026

09/05/2026

Collagen is the most abundant protein in the human body, forming the structural framework of skin, bones, tendons, ligaments, and joint cartilage. Research has established that the body's natural collagen synthesis begins declining at approximately 1 percent per year from the mid-twenties onward, with the rate of decline accelerating significantly after age 40.
In joints specifically, collagen forms the cartilage that cushions bones from impact and friction. As collagen declines cartilage thins and becomes less resilient, contributing to joint pain, stiffness, and increased injury risk over time. A randomized controlled trial published in Current Medical Research and Opinion found that participants who supplemented with hydrolyzed collagen for 24 weeks experienced significant reductions in joint pain during activity and improved joint flexibility compared to the placebo group.
Vitamin C is essential for collagen synthesis because it is required for the enzyme that converts proline to hydroxyproline, a critical step in building stable collagen fibers. Research published in the American Journal of Clinical Nutrition found that consuming vitamin C alongside hydrolyzed collagen significantly increased collagen synthesis in connective tissue compared to collagen alone.
Dietary sources that support collagen production include bone broth, chicken skin, fish, egg whites, and foods rich in vitamin C, glycine, and proline. The combination of these nutrients provides the raw materials the body needs to maintain collagen synthesis naturally.
Shared for information purpose only.
Source: Clark et al., Current Medical Research and Opinion

09/05/2026

A controversial new Alzheimer’s study from the ADNI (Alzheimer’s Disease Neuroimaging Initiative) database suggests omega-3 supplementation may be linked to faster cognitive decline in older adults — challenging the long-held belief that fish oil universally protects the brain.

Researchers found:
🧠 Faster decline in memory and cognition scores
🧠 No link to amyloid or tau buildup
🧠 Possible association with reduced brain glucose metabolism (FDG-PET hypometabolism)

But there’s an important catch:
⚠️ The study was observational and does NOT prove causation.

Major limitations include:
• Reverse causation (people with memory concerns may be more likely to take omega-3s)
• Unknown supplement quality and oxidation status
• No detailed assessment of DHA/EPA dose or fish intake

Key takeaway:
Omega-3 supplements may not be a “one-size-fits-all” brain health solution. Quality, dosage, metabolic health, genetics, and timing likely matter more than previously thought.

The study raises important questions — but it’s far too early to conclude that fish oil causes dementia.



Source: Liao ZB et al. (2026). The association between omega-3 supplementation and cognitive decline in older adults. The Journal of Prevention of Alzheimer’s Disease.

31/03/2026

A study of nearly 96,000 people published today in the European Heart Journal has found that just 15 to 20 minutes of vigorous physical activity per week is linked to a 63% lower risk of dementia, a 60% lower risk of type 2 diabetes, and a 46% lower risk of death. The key finding overturns the assumption that total exercise time is what matters most — researchers discovered that how hard you move, not merely how long, is the decisive factor for several of the most feared diseases of aging. During vigorous activity, the kind that briefly leaves you breathless, your heart pumps more efficiently, blood vessels grow more flexible, and inflammation throughout the body measurably drops. Think of it this way — running to catch a bus, taking stairs two at a time, or playing hard with a child for a few minutes counts as medicine your doctor currently cannot prescribe. The research team, led by Professor Minxue Shen of Central South University, noted that intensity appears especially critical for inflammatory conditions such as arthritis and psoriasis, where the duration of activity mattered far less than its intensity. These findings open the door to personalized activity recommendations based on individual disease risk rather than one-size-fits-all weekly step targets.
Shared for information purpose only.
Source: Wei et al., European Heart Journal, 2026. DOI: 10.1093/eurheartj/ehag168.

28/03/2026

Check out One Day MD’s video.

28/03/2026

Every vitamin performs a defined biochemical function.
When that function is compromised, downstream systems are affected.

This visual maps vitamins not as abstract “nutrients,” but as biological operators embedded across skeletal, immune, neurological, hematologic, and connective tissue systems.

⬇️

🧬 Function specificity
Vitamins act as cofactors, regulators, and structural enablers, not interchangeable inputs.

🧠 System integration
Deficiencies rarely present in isolation. Hormonal balance, immune signaling, red blood cell formation, and neural integrity are tightly coupled.

🦴 Structural dependence
Bone, connective tissue, and vascular health depend on coordinated vitamin activity (e.g., D–K–calcium directionality).

⚠️ Deficiency ≠ absence
Clinical dysfunction often emerges from suboptimal status, not outright deficiency (fatigue, impaired immunity, poor wound healing, and cognitive changes).

📈 Absorption matters
Bioavailability, form, and nutrient pairing determine physiological impact, not label presence alone.

The takeaway is simple but often ignored:
Micronutrients are not optional accessories, they are required instructions.

Understanding nutrition at this level shifts the conversation from “what to take” to what fails when something is missing.

Every vitamin has a job.
Every deficiency has a consequence.

27/03/2026

This is something I wish every patient understood.

Cancer doesn't appear overnight. The most common cancers, including lung, breast, colorectal, and prostate, have a latency period of 20 years or more. That means the biology is shifting long before any scan or test picks it up.

Researchers have identified 10 hallmarks of cancer. These are the biological processes that drive a cell from normal to malignant. The pharmaceutical industry designs drugs to target each one individually.

But here's what's remarkable: whole plant foods contain compounds that influence all 10 hallmarks simultaneously. Berries, greens, cruciferous vegetables, legumes. No single drug can match that breadth.

This isn't a claim that broccoli cures cancer. It's a recognition that the compounds in whole foods, anthocyanins, sulforaphane, flavonoids, work across multiple pathways at once. Food synergy. The whole is greater than the sum of its parts.

The foundation of cancer prevention, according to the most extensive report on diet and cancer ever published, is not a pill. It's a plate. More whole grains, vegetables, fruits, and beans. Less alcohol, processed meat, and ultra-processed food.

You can't control every risk factor. But you can control your next meal.

One extra serving of cruciferous vegetables today. That's the starting line.

26/03/2026

26/03/2026