18/08/2022
胃苏颗粒联合铝碳酸镁治疗反流性胃炎的临床研究
Clinical study on Weisu Granules combined with hydrotalcite in treatment of reflux gastritis
Abstract: Objective To explore the clinical effect of Weisu Granules combined with hydrotalcite in treatment of reflux gastritis.
Methods Patients (80 cases) with reflux gastritis in Chinese Medicine Hospital of Yulin from March 2015 to March 2016 were randomly divided into control and treatment groups, and each group had 40 cases. Patients in the control group were po administered with Hydrotalcite Tablets, 2 tablets/time, three times daily. Patients in the treatment group were po administered with Weisu Granules on the basis of the control group, 3 bag/time, three times daily. Patients in two groups were treated for 2 weeks. After treatment, the clinical efficacies were evaluated, and the changes of clinical symptoms, quality of life, vasoactive intestinal peptide (VIP), and IL-6 in two groups were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 80.00% and 95.00%, respectively, and there was difference between two groups (P < 0.05). After treatment, the scores of clinical symptoms and GERD-HRQL in two groups were significantly decreased, and the difference was statistically significant in the same group (P < 0.05). And the observational indexes in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P < 0.05). After treatment, the levels of VIP and IL-6 in two groups were significantly decreased, and the difference was statistically significant in the same group (P < 0.05). And the observational indexes in the treatment group were significantly lower than those in the control group, with significant difference between two groups (P < 0.05).
Conclusion Weisu Granules combined with hydrotalcite has the clinical curative effect in treatment of reflux gastritis, and can improve clinical symptoms, decrease inflammatory reaction, enhance quality of life, which has a certain clinical application value.
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反流性胃炎是消化系统常见的一种疾病,其临床特点为病程长、难以根治且很容易反复发作,其原因在于胃部手术和幽门松弛致使十二指肠内容物逆流所导致的,造成消化道黏膜受损,临床上以恶心呕吐、腹胀、腹痛及烧心等为...