
10/07/2025
Causes of IVF Failure: Difficult Embryo Transfer
One critical but often overlooked cause of IVF failure is difficult embryo transfer, typically resulting from issues with the cervix or uterine cavity. To improve the chances of success, a thorough pre-IVF evaluation is essential.
Women preparing for IVF should undergo a sono-hysterogram (saline infusion sonography) performed by a skilled specialist. This imaging procedure helps identify potential abnormalities within the uterine cavity and assess the patency and accessibility of the cervix.
When the cervix is narrowed or distorted—a condition known as cervical stenosis—it can be difficult to insert the embryo transfer catheter smoothly. A traumatic or forceful transfer can cause cervical or endometrial bleeding. If the catheter is contaminated with blood during the transfer, it may negatively affect embryo viability, leading to implantation failure. Unfortunately, the patient is often unaware of these complications, as the procedure is usually performed under sedation. However, the attending fertility specialist would recognize when the transfer conditions were suboptimal.
To avoid this, any detected cervical abnormalities should be addressed in advance. This may involve cervical dilation, medical softening agents, or a diagnostic hysteroscopy to ensure the cervical canal is clear and accessible for a smooth embryo transfer.
Early detection and intervention can significantly improve the success rate of IVF procedures.
WOJUADE KEHINDE SAMUEL IS THE FERTILITY SCIENTIST AT ABIMS FERTILITY AND ANDROLOGY IKEJA, LAGOS.