17/05/2025
A brand-new male contraceptive has just been tested in mice, and the results are pretty exciting. This isn't your usual hormone-based solution; it's a drug called CDD-2807 that doesn’t mess with hormones, and it seems to work without causing major side effects. What's even cooler? It's fully reversible, so once you stop the treatment, fertility comes back!
Here’s the science behind it: CDD-2807 targets a protein called STK33, which plays a big role in how s***m become active. When this protein is inhibited, it slows down s***m movement and decreases the number of hyperactive s***m, making them less likely to fertilize an egg. Researchers at Baylor College of Medicine tested the drug on male mice for 21 days, and during that time, none of the treated mice fathered any offspring. But after about 53 days without the drug, the males regained their ability to reproduce. So, it works and it’s reversible!
One of the best things about CDD-2807 is that it didn’t cause any major side effects in the mice. No brain issues, no change in the size of their te**es, and the drug didn’t accumulate in their systems. It’s also important to note that this isn’t some one-time miracle; the effect only lasts as long as the drug is active, and once it’s stopped, the mice returned to being fertile. That’s a big deal because it means no long-term damage.
For years, scientists have been working on finding a male contraceptive that’s as easy and effective as female birth control. We've seen a lot of ideas, from hormonal injections to nanoparticles that heat up the testicles, but most of them have had mixed results or scary side effects. CDD-2807 seems to be the real deal, and it doesn't come with all the risks that some other methods have shown.
The researchers are now planning to test this drug on non-human primates, which is the next step before moving into human trials. So while we're still a ways away from seeing this on the market, the research so far is super promising!
