30/09/2025
Brain scans reveal why some depression cases don’t improve with typical drugs.
Researchers have discovered a new kind of depression called the cognitive biotype that hits memory, concentration, and planning hard, showing up in about a quarter of people with depression and not responding well to typical antidepressants.
In a study of over 700 untreated patients, those with this type had lower brain activity in areas responsible for focus and decision-making and were less likely to get better with standard meds. Knowing this could help doctors spot who has this harder-to-treat depression early and offer different therapies, like ADHD medications, that target the specific brain circuits involved.
RESEARCH PAPER 📄
PMID: 37318808