Maastricht Clinical Neuro Imaging

01/07/2020

To those interested, thank you so much for liking this page!
My research focuses on the application of advanced MRI methodology and analysis methods in cognitive and other neurological disorders.
Although I'm more active on twitter (https://twitter.com/jfajansenphd), I occasionally update this page as well. Today, I'd like to refer you to my website, in which I list my main topics and some highlights.
https://www.jansenjfa.com/research/

Some of my favorite topics include Neurotransmitter MR Spectroscopy, Advanced Diffusion Models, High Field MR, and Myelin Imaging.

Thanks!

My research focuses on the application of advanced MRI methodology and analysis methods in cognitive and other neurological disorders. Click on the topics for some highlights (for complete list see Publications)

12/05/2020

The last chapter from Gerald’s PhD thesis made it to pubmed. The work described in this article was based on the MSc project from Floor Fasen, who was supervised by Gerald. We investigated the brain functional networks of children with Childhood Absence Epilepsy, and it was published in our frequent journal: Neuroimage Clinical. Enjoy!

https://pubmed.ncbi.nlm.nih.gov/32387851/

While cognitive impairments are not generally considered to be part of the childhood absence epilepsy (CAE) syndrome, some recent studies report cognitive, mainly attentional, deficits. Here we set out to investigate the whole brain functional network of children with CAE and controls. Furthermore,....

09/04/2020

Geralds latest work, which combines Myelin imaging with DTI has also been published:

Constructing an Axonal-Specific Myelin Developmental Graph and Its Application to Childhood Absence Epilepsy
Gerhard S Drenthen et al. J Neuroimaging. 2020

https://onlinelibrary.wiley.com/doi/full/10.1111/jon.12707

On February 7th 2020 Gerald Drenthen succesfully defended his PhD thesis, in which he developed myelin MRI imaging techniques and applied these to children with absence epilepsy. These are some of his recent publications:

A new analysis approach for T2 relaxometry myelin water quantification: Orthogonal Matching Pursuit. Drenthen, G. S.; Backes, W. H.; Aldenkamp, A. P.; Op 't Veld, G. J.; and Jansen, J. F. A. Magn Reson Med, 81(5): 3292-3303. 2019.
http://www.ncbi.nlm.nih.gov/pubmed/30444019

Applicability and reproducibility of 2D multi-slice GRASE myelin water fraction with varying acquisition acceleration. Drenthen, G. S.; Backes, W. H.; Aldenkamp, A. P.; and Jansen, J. F. A. Neuroimage, 195: 333-339. 2019.
http://www.ncbi.nlm.nih.gov/pubmed/30965132

Lower myelin-water content of the frontal lobe in childhood absence epilepsy. Drenthen, G. S.; Fonseca Wald, E. L. A.; Backes, W. H.; Debeij-Van Hall, M. H. J. A.; Hendriksen, J. G. M.; Aldenkamp, A. P.; Vermeulen, R. J.; Klinkenberg, S.; and Jansen, J. F. A. Epilepsia, 60(8): 1689-1696. 2019.
http://www.ncbi.nlm.nih.gov/pubmed/31283841

On the merits of non-invasive myelin imaging in epilepsy, a literature review
Gerhard S Drenthen, Walter H Backes, Albert P Aldenkamp, R Jeroen Vermeulen, Sylvia Klinkenberg, Jacobus F A Jansen
Journal of Neuroscience Methods
Volume 338, 15 May 2020, 108687
https://www.sciencedirect.com/science/article/pii/S0165027020301096

30/03/2020

On February 7th 2020 Gerald Drenthen succesfully defended his PhD thesis, in which he developed myelin MRI imaging techniques and applied these to children with absence epilepsy. These are some of his recent publications:

A new analysis approach for T2 relaxometry myelin water quantification: Orthogonal Matching Pursuit. Drenthen, G. S.; Backes, W. H.; Aldenkamp, A. P.; Op 't Veld, G. J.; and Jansen, J. F. A. Magn Reson Med, 81(5): 3292-3303. 2019.
http://www.ncbi.nlm.nih.gov/pubmed/30444019

Applicability and reproducibility of 2D multi-slice GRASE myelin water fraction with varying acquisition acceleration. Drenthen, G. S.; Backes, W. H.; Aldenkamp, A. P.; and Jansen, J. F. A. Neuroimage, 195: 333-339. 2019.
http://www.ncbi.nlm.nih.gov/pubmed/30965132

Lower myelin-water content of the frontal lobe in childhood absence epilepsy. Drenthen, G. S.; Fonseca Wald, E. L. A.; Backes, W. H.; Debeij-Van Hall, M. H. J. A.; Hendriksen, J. G. M.; Aldenkamp, A. P.; Vermeulen, R. J.; Klinkenberg, S.; and Jansen, J. F. A. Epilepsia, 60(8): 1689-1696. 2019.
http://www.ncbi.nlm.nih.gov/pubmed/31283841

On the merits of non-invasive myelin imaging in epilepsy, a literature review
Gerhard S Drenthen, Walter H Backes, Albert P Aldenkamp, R Jeroen Vermeulen, Sylvia Klinkenberg, Jacobus F A Jansen
Journal of Neuroscience Methods
Volume 338, 15 May 2020, 108687
https://www.sciencedirect.com/science/article/pii/S0165027020301096

21/01/2020

We are recruiting a new PhD student on ultra-high field (7.0T) MRI in epilepsy.

The School for Mental Health and Neuroscience has a vacancy for a PhD student 4 years Project title: Value of Ultra High field MRI for focal epilepsy (EpiUltra study)

13/01/2020

The official press release (in Dutch) for our Horizon2020 grant capture, in which we will investigate heart failure and vascular dementia with advanced MRI techniques.

Nieuws | 13 januari 2020 Onderzoek naar gedeelde oorzaak hartfalen en vasculaire dementie Actueel › Nieuws › Onderzoek naar gedeelde oorzaak hartfalen en vasculaire dementie Europese miljoenensubsidie voor onderzoek naar de kleinste bloedvaatjes in hart en breinWetenschappers van het Maastricht ...

03/11/2019

https://m.limburger.nl/cnt/dmf20191101_00130680/hersenen-worden-sneller-ouder-door-diabetes

Diabetes maakt hersenen sneller ouder. Dit blijkt uit een studie naar ruim tweeduizend MRI-scans in het MUMC. Het ziekenhuis hoopt vooral dat mensen met pr...

02/11/2019

Some local media attention (De Limburger, Nov 2nd ‘19) for our recent work in Diabetes Care https://care.diabetesjournals.org/content/early/2019/10/09/dc19-0762.long

18/09/2019

Very happy with this one, our work on white matter connectivity in prediabetes and T2DM has been accepted in Diabetes Care (IF 15.27), a new high for me 🤗

05/09/2019

Very happy with this one, after inspiration from Vera Keil at the 2015 ISMRM, we are now able to show the merits of the spectral diffusion analysis in disease:
Spectral Diffusion Analysis of Intravoxel Incoherent Motion MRI in Cerebral Small Vessel Disease https://onlinelibrary.wiley.com/doi/full/10.1002/jmri.26920

15/08/2019

It took some perseverance, but our spectral IVIM work in cSVD has finally found its home in JMRI 😉

09/08/2019

The multi-institutional Horizon2020 grant, in which we also play an important role, has been awarded 6M€. CRUCIAL - MiCRovascular rarefaction in vascUlar Cognitive Impairment and heArt faiLure.

08/08/2019

Optimal Detection of Subtle Gadolinium Leakage in CSF with Heavily T2-Weighted Fluid-Attenuated Inversion Recovery Imaging http://www.ajnr.org/content/early/2019/08/08/ajnr.A6145

06/08/2019

We are currently hiring 2 PhD students: 1 in population imaging, and 1 in post-stroke epilepsy:

https://www.academictransfer.com/nl/284946/phd-student-faculty-of-health-medicine-and-life-sciences-school-for-mental-health-and-neuroscience/

https://www.academictransfer.com/nl/285029/phd-candidate-position-imaging-of-blood-brain-barrier-leakage-as-a-prediction-for-post-stroke-epilepsy/

The School for Mental Health and Neuroscience has a vacancy for a PhD student Project title: Use it or lose it - Brain reserve as a resilience factor for cognitive and mental health

02/08/2019

We are hiring a PhD student in population imaging.
https://www.academictransfer.com/en/284946/phd-student-faculty-of-health-medicine-and-life-sciences-school-for-mental-health-and-neuroscience/

The School for Mental Health and Neuroscience has a vacancy for a PhD student Project title: Use it or lose it - Brain reserve as a resilience factor for cognitive and mental health

10/07/2019

Don't forget to check out my website! https://www.jansenjfa.com/

I am a neuroscientist working at the Maastricht University Medical Center, with an expertise in neuroimaging and a background in chemistry and biomedical engineering. I aim to answer clinically relevant neurological questions using advanced MRI, in order to obtain a better understanding of the under...

09/07/2019

Apologies for not updating this page more often. Here are some recent highlights, please also check twitter: https://twitter.com/jfajansenphd

15/03/2019

Blood-brain barrier impairment and hypoperfusion are linked in cerebral small vessel disease. https://n.neurology.org/content/early/2019/03/13/WNL.0000000000007263/tab-article-info

23/12/2018

We’re hiring a PhD student on ultra-high imaging in Alzheimers Disease!

The position is funded by Alzheimer Nederland, on the topic “Glymphatic dysfunction and cognitive impairment: a memory clinic study”. Candidates’ work aims to tailor and apply innovative MRI techniques at ultra-high field (7T) yielding metrics...

16/11/2018

Our work in MRM just came out

Magnetic Resonance in Medicine Volume 0, Issue 0 FULL PAPER Open Access A new analysis approach for T2 quantification: Orthogonal Matching Pursuit Gerhard S. Drenthen School for Mental Health and Neuroscience, Maastricht University Medical Center, Maastricht, the Netherlands Department of Radiology....

12/11/2018

Good news from Alzheimer Nederland, our 200k€ major proposal "Glymphatic dysfunction and cognitive impairment: a memory clinic study" has been awarded funding.

16/10/2018

Another high impact factor (>13) one: Prediabetes Is Associated With Structural Brain Abnormalities: The Maastricht Study http://care.diabetesjournals.org/content/early/2018/10/10/dc18-1132

OBJECTIVE Structural brain abnormalities are key risk factors for brain diseases, such as dementia, stroke, and depression, in type 2 diabetes. It is unknown whether structural brain abnormalities already occur in prediabetes. Therefore, we investigated whether both prediabetes and type 2 diabetes a...

01/10/2018

The latest work, based on a dataset I acquired over 10y ago:
“Structural covariance networks relate to the severity of epilepsy with focal-onset seizures”

https://www.sciencedirect.com/science/article/pii/S2213158218302985?via%3Dihub

The brains of patients with epilepsy may exhibit various morphological abnormalities, which are often not directly visible on structural MR images, as…

01/10/2018

Focal application of accelerated iTBS results in global changes in graph measures

https://onlinelibrary.wiley.com/doi/abs/10.1002/hbm.24384

Human Brain Mapping Volume 0, Issue 0 RESEARCH ARTICLE Open Access Focal application of accelerated iTBS results in global changes in graph measures Deborah C. W. Klooster Corresponding Author E-mail address:d.c.w.klooster@tue.nl http://orcid.org/0000-0002-9850-9192 Department of Electrical Engineer...

15/09/2018

We are hiring a PhD student on population imaging, apply now! https://www.academictransfer.com/en/49741/phd-candidate-faculty-of-health-medicine-and-life-sciences-school-for-mental-health-and-neuroscience-department-of-radiology/

The position is embedded in the Maastricht Study, a population study of diabetes mellitus type 2 and cardiovascular disease, of which approximately 5500 participants underwent advanced MRI imaging. Candidates’ work aims to accomplish brain volumetric...

12/08/2018

So true!

“The world of precision medicine and artificial intelligence, in a nutshell!”

01/08/2018

Interesting development!

“One step closer to the clinics: Nir Lipsman, Sandra Black and colleagues publish a phase I trial showing they can safely use magnetic resonance-guided focused ultrasound to open the blood-brain barrier of patients with Alzheimer's disease. https://t.co/71gt4bMFnU”

24/07/2018

Our work introducing the concept of neurotransmitter networks, published in Neuroimage Clinical:
High field imaging of large-scale neurotransmitter networks: Proof of concept and initial application to epilepsy, finally hit pubmed: https://t.co/rC6bsu53bz

Neuroimage Clin. 2018 Apr 4;19:47-55. doi: 10.1016/j.nicl.2018.04.006. eCollection 2018.

28/06/2018

Cross-Sectional Associations Between Cardiac Biomarkers, Cognitive Performance, and Structural Brain Changes Are Modified by Age https://t.co/CqrjAjrkAY

Objective— NT-proBNP (N-terminal pro-B-type natriuretic peptide) and cardiac troponin T (cTNT) are associated with cognitive performance. Whether this extends to individuals

29/05/2018

Abnormal Blood Oxygen Level–Dependent Fluctuations in Focal Cortical Dysplasia and the Perilesional Zone: Initial Findings https://t.co/HHb0taJ2Hk

BACKGROUND AND PURPOSE: Focal cortical dysplasia is a common cause of intractable epilepsy for which neurosurgery is an option. Delineations of a focal cortical dysplasia lesion on structural brain images may not necessarily reflect the functional borders of normal tissue. Our objective was to deter...