Internal Medicine Interest Group

13/06/2025

Diabetic neuropathy tends to affect longer nerve axons initially, therefore patients typically first present with symptoms in their feet.
Screening test : tuning fork test

06/05/2025

S/p cholecystectomy shows a huge cholesterol stone with multiple tiny stones

27/04/2025

Guillain-Barré Syndrome

25/03/2025

18/11/2023

anti-arrhythmic

12/11/2023

Difference between myasthenia crisis and cholinergic crisis

09/10/2023

Spot dx?

29/09/2023

ECG of long Qt

29/09/2023

Congenital LQTS
Congenital LQTS arises from mutations in genes that code for ion channels within myocytes (e.g., KCNE1 gene, located on chromosome 11p that encodes potassium channels in the heart and inner ear)
These mutations all cause ventricular action potentials to be prolonged, resulting in a lengthened QT interval on ECG.
LQTS type 1
Most common type of congenital LQTS
Loss of function mutation on the KCNQ1 gene located on chromosome 11p → defective slow delayed rectifier voltage-gated potassium channel → affected repolarization phase
Subtypes
1. Jervell and Lange-Nielsen syndrome
-Associated with congenital deafness
-Autosomal recessive
-Associated with ventricular tachyarrhythmias
2. Romano-Ward syndrome
-No associated deafness
-Autosomal dominant
-Associated with ventricular tachyarrhythmias

13/09/2023

Gurd's criteria for dx of Fat embolism.