NIMS NEPAL

02/09/2022

Aripiprazole shortage

The Department of Health says some strengths of the anti-psychotic drug remain available.

11/08/2022

BENZODIAZEPAMS:
Lorazepam, Diazepam , Chlordizepoxide withdrawal symptoms may be even worse then the condition for which drug was prescribed.

25/07/2022

Exenatide must be given by subcutaneous injection within 60 minutes before the morning and evening meals. It should not be given after a meal.

Liraglutide is the other GLP-1 mimetic currently available. One the main advantages of liraglutide over exenatide is that it only needs to be given once a day.

29/11/2021

22/08/2021

3

19/08/2021

Carbamazepine is a well-recognised cause of hyponatraemia, which occurs in a dose-related manner and is reversible after drug cessation.

17/08/2021

Pharmacology Classifications :

17/04/2021

Carbapenemase producing enterobacteriaceae (CPE) are multi-drug resistant coliforms.
They can be treated with polymyxins (e.g. colistin), tigecycline, fosfomycin or aminoglycosides (e.g. gentamicin)

06/02/2021

https://play.google.com/store/apps/details?id=np.com.clinicalmedicalmnemonic&hl=en&gl=US

04/01/2021

Cyclin-dependent kinase (CDK) 4/6 pathway inhibitors
*Palbociclib, Ribociclib, Abemaciclib
*Breast cancer, especially ER+, HER2 -
*Used with aromatase inhibitors

07/12/2020

Patients with MI secondary to co***ne use should be given IV benzodiazepines as part of acute (ACS) treatment

07/12/2020

Metformin should be titrated slowly, leave at least 1 week before increasing dose
(Metformin 500mg od with food for 14 days then metformin 500mg bd for 14 days then review)

03/12/2020

Tolterodine is a competitive, specific muscarinic receptor antagonist with relative tissue selectivity for the bladder so that other systemic anticholinergic effects are less pronounced, such as dry mouth or tachycardia.

03/12/2020

Nabilone is a synthetic cannabinoid that has been shown to have significant anti-emetic activity in patients undergoing chemotherapy, although its precise mechanisms of action are
poorly understood.

06/11/2020

Gemfibrozil and trimethoprim inhibit activity of the CYP2C8 isoenzyme and,therefore, increase pioglitazone concentrations and increase the risk of adverse effects.

11/10/2020

Standard post-exposure prophylaxis, as recommended by most recent guidelines, is triple therapy with tenofovir + emtricitabine plus raltegravir, which should be continued for at least 28 days.

06/10/2020

Dipyridamole is a PDE inhibitor that leads to an increase in intracellular cyclic AMP, and this in turn blocks the platelet response to ADP.

26/09/2020

Angiogenesis inhibitors have been shown to treat cancer by halting tumour growth and stopping the formation of new blood vessels in these tumours.
The most widely used angiogenesis inhibitor,
bevacizumab, is a vascular endothelial growth factor (VEGF) inhibitor and is used in the management of colorectal cancer.