Novothor at Laser Institute NZ

Novothor at Laser Institute NZ Bringing you the art & science of human healing & health optimisation through Light, by the leading

19/12/2024

NovoTHOR Red Light Therapy Bed: Reduce your pain, improve your health, and increase your performance.

18/12/2024

Well, it wonโ€™t fit under the treeโ€ฆ
Give us a jingle if you want the gift of great health.

Visit https://www.novothor.com/

NovoTHOR THOR Laser Photomedicine

05/11/2024
14/10/2024

Red light therapy stimulates the bodyโ€™s natural processes using a mix of scientifically determined wavelengths.

Want to learn more?
Visit https://www.novothor.com/

29/09/2024

NovoTHOR uses red and near-infrared light to treat injuries, reduce pain, relax muscles/joints, and increase blood circulation.

๐‚๐ž๐ฅ๐ฅ๐ฎ๐ฅ๐š๐ซ ๐ž๐Ÿ๐Ÿ๐ž๐œ๐ญ๐ฌ ๐จ๐Ÿ ๐ฅ๐จ๐ฐ ๐ฉ๐จ๐ฐ๐ž๐ซ ๐ฅ๐š๐ฌ๐ž๐ซ ๐ญ๐ก๐ž๐ซ๐š๐ฉ๐ฒ ๐œ๐š๐ง ๐›๐ž ๐ฆ๐ž๐๐ข๐š๐ญ๐ž๐ ๐›๐ฒ ๐ง๐ข๐ญ๐ซ๐ข๐œ ๐จ๐ฑ๐ข๐๐žKaru, et.al.[...]Study Design/Materials and M...
14/08/2023

๐‚๐ž๐ฅ๐ฅ๐ฎ๐ฅ๐š๐ซ ๐ž๐Ÿ๐Ÿ๐ž๐œ๐ญ๐ฌ ๐จ๐Ÿ ๐ฅ๐จ๐ฐ ๐ฉ๐จ๐ฐ๐ž๐ซ ๐ฅ๐š๐ฌ๐ž๐ซ ๐ญ๐ก๐ž๐ซ๐š๐ฉ๐ฒ ๐œ๐š๐ง ๐›๐ž ๐ฆ๐ž๐๐ข๐š๐ญ๐ž๐ ๐›๐ฒ ๐ง๐ข๐ญ๐ซ๐ข๐œ ๐จ๐ฑ๐ข๐๐ž
Karu, et.al.

[...]
Study Design/Materials and Methods - A suspension of HeLa cells was irradiated with a monochromatic visible-to-near infrared radiation (600โ€“860 nm, 52 J/m2) or with a diode laser (820 nm, 8โ€“120 J/m2) and the number of cells attached to a glass matrix was counted after 30 minute incubation at 37ยฐC. The NO donors sodium nitroprusside (SNP), glyceryl trinitrate (GTN), or sodium nitrite (NaNO2) in the concentration range 5 ร— 10โˆ’9โ€“5 ร— 10โˆ’4M were added to the cellular suspension before or after irradiation. The action spectra and the concentration and fluence dependencies obtained were compared and analyzed.

Results - The well-structured action spectrum for the increase of the adhesion of the cells, with maxima at 619, 657, 675, 740, 760, and 820 nm, points to the existence of a photoacceptor responsible for the enhancement of this property (supposedly cytochrome c oxidase, the terminal respiratory chain enzyme), as well as signaling pathways between the cell mitochondria, plasma membrane, and nucleus. Treating the cellular suspension with SNP (5 ร— 10โˆ’5M) before irradiation significantly modifies the action spectrum for the enhancement of the cell attachment property (band maxima at 642, 685, 700, 742, 842, and 856 nm). The action of SNP, GTN, and NaNO2 added before or after irradiation depends on their concentration and radiation fluence.

Conclusions - The NO donors added to the cellular suspension before irradiation eliminate the radiation-induced increase in the number of cells attached to the glass matrix, supposedly by way of binding NO to cytochrome c oxidase. NO added to the suspension after irradiation can also inhibit the light-induced signal downstream. Both effects of NO depend on the concentration of the NO donors added. These results indicate that NO can control the irradiation-activated reactions that increase the attachment of cells.

https://doi.org/10.1002/lsm.20148

Background and Objectives The objective of this study was to investigate the possibility of involvement of nitric oxide (NO) into the irradiation-induced increase of cell attachment. These experimen...

14/07/2023

๐๐ก๐จ๐ญ๐จ๐›๐ข๐จ๐ฆ๐จ๐๐ฎ๐ฅ๐š๐ญ๐ข๐จ๐ง ๐ฉ๐ซ๐ž๐ฌ๐ž๐ซ๐ฏ๐ž๐ฌ ๐ฆ๐ข๐ญ๐จ๐œ๐ก๐จ๐ง๐๐ซ๐ข๐š๐ฅ ๐ซ๐ž๐๐จ๐ฑ ๐ฌ๐ญ๐š๐ญ๐ž ๐š๐ง๐ ๐ข๐ฌ ๐ซ๐ž๐ญ๐ข๐ง๐จ๐ฉ๐ซ๐จ๐ญ๐ž๐œ๐ญ๐ข๐ฏ๐ž ๐ข๐ง ๐š ๐ซ๐จ๐๐ž๐ง๐ญ ๐ฆ๐จ๐๐ž๐ฅ ๐จ๐Ÿ ๐ซ๐ž๐ญ๐ข๐ง๐ข๐ญ๐ข๐ฌ ๐ฉ๐ข๐ ๐ฆ๐ž๐ง๐ญ๐จ๐ฌ๐š
Gopalakrishnan, et.al.

[...] Our laboratory has shown that FR PBM improves functional and structural outcomes in animal models of retinal injury and retinal degenerative disease. The current study tested the hypothesis that a brief course of NIR (830 nm) PBM would preserve mitochondrial metabolic state and attenuate photoreceptor loss in a model of retinitis pigmentosa, the P23H transgenic rat. P23H rat pups were treated with 830 nm light (180 s; 25 mW/cm2; 4.5 J/cm2) using a light-emitting diode array (Quantum Devices, Barneveld, WI) from postnatal day (p) 10 to p25. Sham-treated rats were restrained, but not treated with 830 nm light. Retinal metabolic state, function and morphology were assessed at p30 by measurement of mitochondrial redox (NADH/FAD) state by 3D optical cryo-imaging, electroretinography (ERG), spectral-domain optical coherence tomography (SD-OCT), and histomorphometry. PBM preserved retinal metabolic state, retinal function, and retinal morphology in PBM-treated animals compared to the sham-treated group. PBM protected against the disruption of the oxidation state of the mitochondrial respiratory chain observed in sham-treated animals. Scotopic ERG responses over a range of flash intensities were significantly greater in PBM-treated rats compared to sham controls. SD-OCT studies and histological assessment showed that PBM preserved the structural integrity of the retina. These findings demonstrate for the first time a direct effect of NIR PBM on retinal mitochondrial redox status in a well-established model of retinal disease. They show that chronic proteotoxic stress disrupts retinal bioenergetics resulting in mitochondrial dysfunction, and retinal degeneration and that therapies normalizing mitochondrial metabolism have considerable potential for the treatment of retinal degenerative disease.

https://www.nature.com/articles/s41598-020-77290-w

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