03/12/2024
The team at the Centre for Chiropractic Research at the New Zealand College of Chiropractic are excited to share the results of a ground-breaking clinical trial exploring the impact of chiropractic care on brain activity and health outcomes. This study is called ‘Neuroplastic Responses to Chiropractic Care: Broad Impacts on Pain, Mood, Sleep, and Quality of Life’ and was published in Brain Sciences in November 2024.
In this study, 76 participants with chronic low back pain were randomised into a control group or chiropractic group. Participants in the chiropractic group received chiropractic care plus their usual care for 4 weeks, while the control group received usual care only. Usual care referred to whatever self-management they were already doing for their aches and pains. For example, they may have been exercising, taking pain medication, or seeing a physical therapist. We didn’t ask them to change their routines, but half of the participants were randomly assigned to also receive chiropractic care for four weeks.
Dr Jerome Poupel, a chiropractor with 30 years of clinical experience, played a key role in delivering the chiropractic care for this study, providing invaluable expertise throughout. This parallel-group randomised controlled design study chiropractic care was conducted at a private chiropractic clinic in Henley-on-Thames, England in 2022/2023.
The recorded outcome measures included resting electroencephalography (EEG), somatosensory evoked potentials (SEPs), sleep and physical activity tracking with a wearable device, and assessments of quality of life and mental health using the PROMIS-29 questionnaire.
One of the most exciting findings in this study was the improvements in mental health observed in the chiropractic group. Over the four weeks of chiropractic care, participants reported significantly less anxiety and depression. These improvements corresponded with notable brain activity changes, including significant increases in theta, alpha, and beta EEG band activity, and decreased delta activity in the chiropractic group. EEG analysis also revealed altered alpha and beta activity within the Default-Mode Network (DMN). The DMN is a critical brain network involved in self-referential thinking, mind-wandering, memory, and emotional regulation. Changes in DMN activity could explain improved mental clarity, emotional balance, and resilience seen in some people who receive chiropractic care. You can explore our supplementary file for a detailed discussion about the DMN changes observed after a single chiropractic session and after four weeks of care.
Data from wearable devices showed significantly improved light sleep stages in the chiropractic group. This aligns with common feedback that people sleep better after chiropractic care. The study provides scientific evidence supporting this feedback. The PROMIS-29 questionnaire revealed significantly reduced levels of anxiety, depression, fatigue, and pain after four weeks of chiropractic care. These findings make this one of the first randomised controlled trials to show improved mental health outcomes following chiropractic care.
The SEPs analysis revealed decreased N30 amplitudes in the chiropractic group, a result consistently observed in our studies over the past 20 years. These changes highlight alterations in early sensorimotor processing pathways. As these changes correspond with improved clinical outcomes, the N30 SEP peak changes might reflect enhanced interoceptive and exteroceptive processing, as well as improved mental and physical quality of life.
It is important to note that none of these findings were observed in the control group. All significant changes were found in the chiropractic care group, suggesting that many of the benefits of chiropractic care are linked to changes in brain activity and neural processing.
A study of this scale requires extensive funding and collaboration, and we are deeply appreciative of the many individuals and organisations who made it possible. Our heartfelt thanks go to Amit Pujari from the School of Physics, Engineering, and Computer Science at the University of Hertfordshire. Without Amit and his doctoral student Moeez Ashfaque, this project could not have come to fruition. We also extend a special thank you to Ernest Nlandu Kamavuako from the Centre for Robotics Research, Department of Informatics at King’s College London. Your invaluable collaboration helped to bring this project to life.
We are profoundly grateful to our funders, including His Grace, the Duke of Bedford; Dr Jerome Poupel; and the Centre for Chiropractic Research Supporters Programme. Their support was essential in making this project possible. It is important to highlight that funders (including the chiropractor) played no role in the study's design, data collection, analysis, publication decisions, or manuscript preparation.
If you would like to support more amazing research like this, please visit: https://chiropractic.ac.nz/research/support-our-research/
To read the full study, visit: https://www.mdpi.com/2076-3425/14/11/1124
For a detailed discussion on DMN changes, see the supplementary file: https://www.mdpi.com/article/10.3390/brainsci14111124/s1
And don’t miss Heidi discussing this study with Jerome and Russell Brand on YouTube: https://www.youtube.com/watch?v=f1QeKW1Wnfg