07/09/2025
Salmon s***m facials, also known as polydeoxyribonucleotide (PDRN) therapy, use purified DNA from salmon s***m to support skin regeneration. Despite the name, the procedure does not involve using raw salmon s***m. Instead, the salmon s***m undergoes a multi-step purification process to remove proteins and other cellular components.
This Korean beauty trend has been popularised by celebrities like Jennifer Aniston and Kim Kardashian, who have been adding salmon s***m facials to their skin care routines for supposed collagen-boosting and anti-aging properties. There are many ways PDRN is used in skincare: microinjections, microneedling and topical treatment.
Clinical and pre-clinical studies suggest that PDRNs may support tissue repair and cell regeneration by stimulating fibroblasts and promoting collagen production. However, some experts note the lack of well-designed human studies and FDA approval, with some benefits possibly attributed to hyaluronic acid, a common accompanying ingredient. If something isn’t FDA-approved, there’s a reason, and the reason is your safety.
Word of mouth and social media can be persuasive; if you’re seeing videos of people with glowing, radiant skin saying they owe it all to salmon s***m, it’s natural to want to try it for yourself. But for every video praising the service, there are more from plastic surgeons or dermatologists saying to hold off and wait for more research along with the FDA approval.
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