01/02/2026
Over the years in clinic, I have seen clients with suboptimal Vitamin D blood results, and this is despite them either being on a prescribed Vitamin D supplement, or, if they like to have their skin exposed to the sun.
Now as I delve more into DNA/Nutrigenomics I can see why for these types of clients, looking at their genetic variants can be super helpful to understand why this might be the case.
Vitamin D plays a critical role within the metabolic system, immune regulation, neurotransmitter function, bone health and inflammation control, however, optimal vitamin D status is not just about sun exposure or supplementationâit is also influenced by your genetics, particularly the VDR gene.
VDR gene provides instructions for making the vitamin D receptor, found throughout tissue in the body such as the intestinal tract, bones, immune cells, brain and more.
As well as laying out instructions for vitamin D activity, the receptor also activates genes and instructions involved in calcium absorption, overall immune defence, and cellular repair.
Currently our lab testing (in NZ) is aimed towards vitamin D levels for bone health. With a range of between 50-150nmol/L regarded as being adequate.
But, Vitamin D is not just for bone health, but also immunity, cardiovascular health, metabolic health, brain function and more. In clinic I prefer to see clients Vitamin D status at least above 100nmol/L or thereabouts.
Potential gene variants may impact upon Vitamin D function affecting how efficiently vitamin D binds to receptor sites, how strongly vitamin D genes can âturn on or offâ, or how well it can be absorbed. This helps explain why some individuals experience symptoms of deficiency despite adequate intake.
This may impact upon not just bone density, but also immune regulation, increased inflammation, autoimmunity risk, and metabolic dysfunction.
From a functional medicine perspective, understanding VDR genetics allows for personalised vitamin D strategies. Some individuals may benefit from higher dosing, understanding the need for co-factors, understanding the need for the right form of vitamin D, or whether intestinal integrity is compromised.
Suggesting foods to increase, or preferred form of vitamin D and dose, based on genetic insight can help tailor nutrition and supplementation strategies for better outcomes, moving beyond standard reference ranges to truly personalised care.
Want to know more, make sure to reach out!