
19/09/2025
The Hormonal Backstory of Depression and Stress
Feeling low, wired but tired, or emotionally fragile after stress?
It’s not “just in your head” — it’s in your hormones, your brain, and your nervous system.
Chronic stress activates a powerful system in your body called the HPA axis (hypothalamus-pituitary-adrenal). When it's overactive, your brain stays stuck in survival mode — pumping out cortisol and disrupting the balance of mood, memory, energy, sleep, and hormones.
In depression, we often see:
✨Elevated cortisol
✨Shrinking of mood-regulating areas like the hippocampus
✨Disruption of thyroid hormones and estrogen
✨Activated inflammation pathways
✨Impaired brain healing (BDNF, glial cells, astrocyte function)
What this means: Stress and depression are biologically connected.
Women's mental wellbeing deserves an approach that's hormone-aware, HPA-axis sensitive, and trauma-informed — because healing happens when we treat the whole system, not just the symptoms on the surface.
✨ Hormones. Mood. Metabolism. It’s all connected.
We'd love to help: click link in bio to book a consult with Dr Deborah Brunt
GP with special interests in integrative and hormonal health.