10/08/2025
This is huge.
I was diagnosed with Myalgic Encephalomyelitis when I was only 18.
My hope is that now, with this new uncovered biological evidence, all the negative stigma and medical gaslighting ceases and new treatments are developed to help improve lives.
Chronic fatigue syndrome also known as myalgic encephalomyelitis (ME/CFS) is not ājust in your head.ā A landmark genetic study has uncovered compelling biological evidence that the illness has deep roots in our DNA. Researchers identified eight regions of the human genome that differ significantly between people with and without ME/CFS, with many of these areas tied to immune system function and nervous system signaling.
The DecodeME project, led by the University of Edinburgh alongside patient groups and charities, analyzed genetic data from more than 15,000 ME/CFS patients and over 250,000 healthy controls. The findings suggest certain genetic variants may increase susceptibility by weakening infection-fighting abilities or altering chronic pain pathways. For millions of people living with debilitating fatigue, brain fog, and post-exertional malaise, these results offer long-awaited validation and a new direction for scientific research.
While thereās still no cure or definitive diagnostic test, this is a turning point in how ME/CFS is understood and treated. The results could lay the groundwork for genetic screening, targeted therapies, and deeper studies into why the condition disproportionately affects women and how it differs from illnesses like long Covid. Above all, itās a powerful step toward ending the stigma and ensuring ME/CFS is recognized as a serious, biologically driven disease. Source: DecodeME Consortium (2025). Genetic associations with myalgic encephalomyelitis/chronic fatigue syndrome.
