08/01/2026
PCOS Polycystic O***y Syndrome and Herbal medicine.
White Paeony and Licorice are 2 x medicinal herbs to lower androgen hormone levels.
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Blessings
Bridgitt The Naturopath, Reflexologist and Alchemist
https://www.maintainingyourhealth.co.nz/herbal-medicine
The Peony-Glycyrrhiza combination (white peony and licorice), known as Shaoyao-Gancao in China or Shakuyaku-kanzo-to (TJ-68) in Japan, is one of the most instructive synergies in East Asian medicine, illustrating how the insightful pairing of herbs can produce effects not reliably conceived or achieved with either herb alone. Anchored by the constituents paeoniflorin and glycyrrhizin, the combination exerts reproducible hormonal, skeletal antispasmodic, analgesic and neuroendocrine-modulating actions with clear clinical relevance.
Clinical research on this pairing has evolved in three discernible phases. In the late 1980s, Takahashi and colleagues explored its use in women with polycystic o***y disease (PCOS), reporting reductions in androgen levels alongside menstrual induction and occasional pregnancies. This endocrine signal was extended in early-to-mid 1990s PCOS studies, which demonstrated significant reductions in total and free testosterone and longer-term shifts consistent with improved ovarian steroidogenesis.
During the 2000s, research attention shifted toward skeletal muscle cramping, a known traditional use. Clinical studies—particularly in haemodialysis patients—demonstrated rapid relief of painful muscle spasms, with reductions in cramp frequency, severity, and duration for both preventive and as-needed use.
More recently, from the 2010s onward, controlled trials have focussed on the formula’s endocrine effects, this time in antipsychotic-induced hyperprolactinaemia (which was also studied in the late 1990s), firmly reframing this ancient herb pair within a contemporary neuroendocrine context. The most recent study in this domain is reviewed in the next posting.
For more information see:
https://pubmed.ncbi.nlm.nih.gov/3292675/
https://pubmed.ncbi.nlm.nih.gov/8012442/
https://pubmed.ncbi.nlm.nih.gov/12943175/
https://pubmed.ncbi.nlm.nih.gov/27363396/
https://pubmed.ncbi.nlm.nih.gov/27755159/