13/03/2026
H**P COMPOUNDS HELP RESTORE INSULIN FUNCTION
New research highlights how molecules from h**p seed hulls may support metabolic health
โ๏ธ What researchers studied
โข Scientists isolated two natural compounds from Cannabis sativa h**p seed hulls
โข These compounds are called Cannabisin A and Cannabisin B
โข The goal was to see whether they could improve metabolic dysfunction linked to diabetes and obesity
โ๏ธ Why this matters
โข A protein called PTP1B blocks insulin and leptin signaling when it becomes overactive
โข This disruption is strongly linked to insulin resistance, weight gain, and type 2 diabetes
โ๏ธ What the study found
โข Both h**p compounds strongly blocked PTP1B activity
โข Cannabisin A was especially potent
โข Cannabisin B also showed strong inhibition
โข By blocking PTP1B, the compounds helped restart several important metabolic pathways
โข Insulin signaling (IRS-1 and AKT)
โข Cellular energy regulation (AMPK)
โข Leptin signaling involved in appetite and metabolism
โ๏ธ Results in cells and animals
โข In insulin-resistant muscle and liver cells, the compounds restored normal glucose uptake
โข In diabetic mice given oral doses
โข Blood sugar levels dropped
โข Glucose tolerance improved
โข Insulin sensitivity improved
โข Researchers also observed healthier metabolic signaling in muscle and liver tissues
โ๏ธ Why the findings are important
โข H**p seed hulls are usually treated as agricultural waste
โข This research shows they contain biologically active molecules that may help regulate metabolism and glucose control
โ๏ธ Bigger picture
โข Cannabis sativa is one of the most versatile plants studied in modern agriculture and medicine
Every part of the plant has value
โข Seeds provide nutrition and beneficial compounds
โข Flowers produce cannabinoids and terpenes used in medicine
โข Leaves contain antioxidants and polyphenols
โข Stalks provide strong natural fiber for textiles and sustainable materials
Few plants offer this level of usefulness while producing almost no waste.
This study adds to growing evidence that compounds from h**p may help support metabolic health by improving how the body responds to insulin and energy signals.
Phytomedicine (2026)
DOI: 10.1016/j.phymed.2026.158054
SOURCE HERE and in Comments
https://www.sciencedirect.com/science/article/abs/pii/S0944711326002904