01/02/2026
Common Liver Diseases :
๐ฃ Fatty Liver (Hepatic Steatosis)
โ Excess triglyceride accumulation in hepatocytes
โ Common causes: obesity, type 2 diabetes, alcohol, metabolic syndrome
โ Usually asymptomatic initially
โ May progress to steatohepatitis โ fibrosis โ cirrhosis
Key labs
โ Mild โ ALT/AST (ALT > AST in NAFLD)
๐ฃ Alcoholic Liver Disease
โ Due to chronic alcohol intake
Progression sequence
โ Fatty liver โ Alcoholic hepatitis โ Cirrhosis
Histology
โ Ballooned hepatocytes
โ MalloryโDenk bodies
โ Neutrophilic infiltration
Labs
โ AST : ALT > 2:1 (classic)
๐ฃ Hepatitis (Viral / Inflammatory)
โ Inflammation of liver parenchyma
Causes
โ Viral (A, B, C, D, E)
โ Autoimmune
โ Drugs / toxins
Symptoms
โ Fatigue, jaundice, RUQ pain, nausea
Chronic hepatitis may lead to
โ Fibrosis
โ Cirrhosis
โ Hepatocellular carcinoma
๐ฃ Liver Cirrhosis
โ Irreversible fibrosis with regenerative nodules
Major consequences
โ Portal hypertension
โ Ascites
โ Varices
โ Hepatic encephalopathy
โ Coagulopathy
Common causes
โ Alcohol
โ Chronic hepatitis B/C
โ NAFLD
๐ฃ Hepatocellular Carcinoma (HCC)
โ Primary liver malignancy
โ Usually develops on cirrhotic liver
Risk factors
โ Chronic HBV/HCV
โ Alcohol
โ NAFLD
Features
โ Weight loss
โ RUQ pain
โ Rising AFP (alpha-fetoprotein)
โ Vascular invasion common
๐ฃ Cholestasis / Bile Duct Obstruction
โ Impaired bile flow
Clinical features
โ Pruritus
โ Pale stools
โ Dark urine
โ Jaundice
Labs
โ โ ALP
โ โ GGT
โ โ Direct bilirubin
Causes
โ Gallstones
โ Tumors
โ Strictures
โ Primary biliary cholangitis
๐ฃ Acute Liver Failure
โ Rapid loss of liver function
Defined by
โ Encephalopathy
โ Coagulopathy (โ INR)
Causes
โ Acetaminophen toxicity (most common)
โ Viral hepatitis
โ Drugs / toxins
Histology
โ Massive hepatocyte necrosis
Medical emergency.
๐ฃ Primary Biliary Cholangitis (PBC)
โ Autoimmune destruction of intrahepatic bile ducts
Typical patient
โ Middle-aged woman
Labs
โ โ ALP
โ Positive antimitochondrial antibodies (AMA)
Leads to
โ Progressive cholestasis
โ Cirrhosis
๐ฃ Portal Hypertension
โ Increased pressure in portal venous system (usually due to cirrhosis)
Consequences
โ Splenomegaly
โ Ascites
โ Esophageal varices
โ Caput medusae
Mechanism
โ Increased intrahepatic resistance + collateral formation