
30/06/2025
BE SURE BE TRISURE.
✅ 1. Non-invasive and safe
No risk of miscarriage, unlike invasive procedures such as amniocentesis or chorionic villus sampling (CVS).
Only requires a simple blood draw from the mother, typically after 9 weeks of pregnancy.
✅ 2. High accuracy
High sensitivity and specificity for common chromosomal abnormalities:
Trisomy 21 (Down syndrome): >99% sensitivity
Trisomy 18 (Edwards syndrome) and Trisomy 13 (Patau syndrome): also highly accurate
Lower false-positive rates compared to traditional first-trimester screening.
✅ 3. Early detection
Can be done as early as 9 weeks of gestation, allowing earlier decision-making, confirmatory testing, or planning.
✅ 4. Broad screening capabilities
Detects common aneuploidies (T21, T18, T13)
Screens for:
S*x chromosome abnormalities (e.g., Turner syndrome)
Microdeletions (e.g., DiGeorge syndrome)
Fetal s*x determination
Rare autosomal trisomies
✅ 5. Suitable for high- and average-risk pregnancies
Initially recommended for high-risk groups (advanced maternal age, abnormal ultrasound), but now widely used in average-risk pregnancies due to its reliability and safety.
✅ 6. Can reduce need for invasive testing
Because of its high accuracy, NIPT reduces the number of women needing invasive follow-up tests, minimizing procedure-related complications.
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