18/09/2025
đ¨BREAKING STUDY: First Direct Evidence of mRNA "Vaccine" Genomic Integration Identified in Stage IV Cancer Patient
We found a vaccine DNA plasmidâderived Spike gene sequence integrated into chromosome 19 with PERFECT 20/20 bp identity â accompanied by widespread genomic dysfunction âŹď¸
We describe a previously healthy 31-year-old woman who developed rapidly progressive stage IV bladder cancer within 12 months of completing a three-dose Moderna mRNA injection series. Bladder cancer is exceedingly rare in young women, and such aggressive presentations are almost unheard of.
To investigate, we performed comprehensive multi-omic profiling, including plasma-derived circulating tumor DNA, whole-blood RNA, and urine exosome proteomics. What we uncovered was striking:
â ď¸DIRECT GENOMIC INTEGRATION EVENT: Within circulating tumor DNA, a hostâvector chimeric read mapped to chr19:55,482,637â55,482,674 (GRCh38), in cytoband 19q13.42, positioned ~367 kb downstream of the canonical AAVS1 safe harbor and ~158 kb upstream of ZNF580 at the proximal edge of the zinc-finger (ZNF) gene cluster. This sequence aligned with perfect 20/20 bp identity to a segment (bases 5905â5924) within the Spike open reading frame (ORF) coding region (bases 3674â7480) of the Pfizer BNT162b2 DNA plasmid reference (GenBank accession OR134577.1).
Although the patient received only Moderna injections, the sequence aligned to Pfizerâs published BNT162b2 plasmid reference because Moderna has never deposited its proprietary plasmid in NCBI. Crucially, both Pfizer and Moderna vaccines encode the same prefusion-stabilized SARS-CoV-2 Spike protein and therefore share identical stretches of nucleotide sequence within the Spike ORF coding region. It is within one of these conserved regions that the integration was captured, producing the perfect 20/20 bp match to the Pfizer reference.
The probability of a random 20-base sequence perfectly matching a predefined target is ~1 in a trillion. This makes accidental artifact virtually impossible.
Multi-omics profiling revealed:
â Oncogene activation (KRAS, NRAS, MAPK1, PIK3CA, CHD4, SF3B1)
â DNA repair collapse (ATM, MSH2) â genomic instability
â Transcriptomic chaos across plasma, blood, and urine
The convergence of (i) close temporal proximity to vaccination, (ii) genomic integration of a vaccine plasmidâderived spike gene fragment, and (iii) consistent transcriptomic and proteomic instability across biospecimens represents a highly unusual and biologically plausible pattern.
These findings demand urgent genomic surveillance, orthogonal validation with long-read sequencing, and large-scale cohort studies to fully assess the genomic and oncologic risks of synthetic mRNA technology.
This evidence compels the immediate withdrawal of all COVID-19 mRNA products from the market. Humanity now confronts the unprecedented threat of vaccine-induced genomic disruptionâa danger too great to ignore
