20/04/2026
[RESETA ISSUE #11]
What is Intermittent Fasting and How It Can Improve Brain Function
Oftentimes, fasting is thought of as a routine to lose weight. However, what if there were a structured approach to fasting that could not only improve physical health, but also enhance brain function? This approach, known as intermittent fasting, has gained increasing attention for its potential cognitive benefits. This article aims to discuss what intermittent fasting is, its potential effects on brain health, and its advantages and limitations as a dietary practice.
Fad diets have become widely used approaches for achieving the ideal body weight through weight reduction (Llanes et al., 2020). These diets are often characterized by their popularity, restrictive patterns, and promises of rapid results, but they may lack long-term sustainability and balanced nutrition (Tahreem et al., 2022). In recent years, both intermittent fasting (IF) and the ketogenic diet (KD) have gained significant popularity among Filipinos (Llanes et al., 2020). Various media platforms have played a key role in promoting these dietary trends, shaping public perception regarding their effectiveness and safety (Llanes et al., 2020).
Intermittent fasting is a dietary pattern that alternates between periods of eating and fasting. This may be done in two ways, including alternate-day fasting (ADF) and time-restricted fasting (TRF) (Liu et al., 2023). ADF involves alternating between “eating days” in which individuals consume approximately 125-150% of calories found from a regular diet, and “fasting days”, in which they reduce their intake to 25% or less (Liu et al., 2023). On the other hand, TRF allows individuals to eat within a limited time window, typically ranging from 3 to 12 hours, followed by fasting for the rest of the day (Liu et al., 2023).
Over time, intermittent fasting may contribute to weight loss and improvements in metabolic health (Londre, 2022; Liu et al., 2023). Beyond this, emerging research suggests that intermittent fasting may also have beneficial effects on brain function. One proposed mechanism is its ability to induce levels of brain-derived neurotrophic factor (BDNF), a protein produced in the central nervous system that plays a key role in synaptic transmissions and neuroplasticity (Alkurd et al., 2024). Neuroplasticity refers to the brain’s ability to adapt and reorganize itself by forming new neural connections (Puderbaugh & Emmady, 2023). In other words, BDNF strengthens connections between neurons in the brain which greatly improves memory formation and learning (Takeuchi et al., 2013; Alkurd et al., 2024). In addition to its cognitive benefits, intermittent fasting has been associated with improved insulin sensitivity, reduced inflammation, and better metabolic regulation (Liu et al., 2023; Nye et al., 2024).
Despite these potential benefits, intermittent fasting is not without limitations. Some individuals may experience adverse effects such as fatigue, headaches, irritability, and difficulty concentrating, particularly during the initial stages of fasting (Nye et al., 2024). Furthermore, some studies suggest that restrictive eating patterns may be associated with reduced bone density and potential hormonal imbalances when practiced long-term without proper nutritional guidance (Nye et al., 2024). Moreover, prolonged or improperly managed fasting may lead to inadequate nutrient intake, which can negatively affect overall health (Tahreem et al., 2022).
Another important consideration is sustainability. While intermittent fasting may produce short-term benefits, maintaining such dietary patterns over the long term can be challenging due to their restrictive nature and the difficulty of adherence over time (Liu et al., 2023; Tahreem et al., 2022). This reflects a broader concern with fad diets, which often emphasize rapid results but may lack long-term sustainability and balanced nutritional intake (Llanes et al., 2020). As a result, individuals may struggle to maintain consistent dietary habits, potentially limiting the long-term effectiveness of these approaches (Liu et al., 2023).
In conclusion, intermittent fasting is a structured dietary practice in which a person sets specific periods or days to fast and eat. While it may offer benefits such as weight loss, improved metabolic health, and enhanced brain function, it also presents potential risks and limitations. As with many fad diets, its effectiveness and safety depend on proper implementation and individual health conditions. Therefore, intermittent fasting should be approached with caution, and individuals are encouraged to consider balanced, sustainable dietary practices when aiming to improve both physical and cognitive health
REFERENCES
Alkurd, R., Mahrous, L., Zeb, F., Khan, M. A., Alhaj, H., Khraiwesh, H. M., & Faris, M. E. (2024). Effect of calorie restriction and intermittent fasting regimens on Brain-Derived Neurotrophic factor levels and Cognitive Function in Humans: a systematic review. Medicina, 60(1), 191. https://doi.org/10.3390/medicina60010191
Llanes, E. J. B., Gonzales, E. M., Reyes, D. R., Gubat, M. J. G., Estipona-Villaraza, M. E., Bautista, J. T., Santos, L. E. G., Rey, N., De Guzman-Quizon, O. Q., Saret, J., Saret, T., Nicodemus, N. A., Matawaran, B. J., & Jimeno, C. A. (2020). Philippine Consensus Statement on the use of ketogenic diet and intermittent fasting diet on Adults for weight reduction. Philippine Journal of Internal Medicine, 58(4), 106–111. https://doi.org/10.65564/pjim.3d944b84ce
Liu, S., Zeng, M., Wan, W., Huang, M., Li, X., Xie, Z., Wang, S., & Cai, Y. (2023). The Health-Promoting Effects and the mechanism of intermittent fasting. Journal of Diabetes Research, 2023, 1–15. https://doi.org/10.1155/2023/4038546
Londre, R. [Romi Londre, RDN, CD]. (2022, June 17). Intermittent fasting: fad or valid weight-loss solution? Mayo Clinic Health System.https://www.mayoclinichealthsystem.org/hometown-health/speaking-of-health/intermittent-fasting-fad-or-solution
Nye, K., Cherrin, C., & Meires, J. (2024). Intermittent Fasting: Exploring approaches, benefits, and implications for health and weight management. The Journal for Nurse Practitioners, 20(3), 104893. https://doi.org/10.1016/j.nurpra.2023.104893
Puderbaugh, M., & Emmady, P. D. (2023, May 1). Neuroplasticity. StatPearls - NCBI Bookshelf. https://www.ncbi.nlm.nih.gov/books/NBK557811/
Tahreem, A., Rakha, A., Rabail, R., Nazir, A., Socol, C. T., Maerescu, C. M., & Aadil, R. M. (2022). Fad diets: Facts and fiction. Frontiers in Nutrition, 9, 960922. https://doi.org/10.3389/fnut.2022.960922
Takeuchi, T., Duszkiewicz, A. J., & Morris, R. G. M. (2013). The synaptic plasticity and memory hypothesis: encoding, storage and persistence. Philosophical Transactions of the Royal Society B Biological Sciences, 369(1633), 20130288. https://doi.org/10.1098/rstb.2013.0288
Article by: Katina Venise P. Lim
Revised by: Mehkiah Ocean D. Bautista & Reiann Marie J. Lampa
Pubmat by: Kervin Chua