08/02/2017
For those at high risk for cardiovascular disease, or are currently being treated with standard therapy such as statin drug, the following study should be of great interest.
RESVERATROL IMPROVES INFLAMMATORY STATUS IN ADULTS AT HIGH RISK FOR CARDIOVASCULAR DISEASE
In a study published in the American Journal of Cardiology, researchers investigated the effects of a dietary supplement containing resveratrol on the inflammatory and fibrinolytic status of adults at high risk of cardiovascular disease (CVD). Subjects were on statin drugs for primary prevention of CVD and at high CVD risk (i.e., with diabetes or hypercholesterolemia plus ≥1 other CV risk factor).
The study included 75 patients that were treated for a period of one year, with a year of follow-up. Subjects were randomized into 3 groups; placebo (maltodextrin), resveratrol rich supplement (8mg), or a conventional grape supplement lacking resveratrol. These dosages were used for the first 6 months, and then doubled for the next 6 months.
In contrast to placebo and conventional grape supplement, the resveratrol-rich grape supplement significantly decreased markers of inflammation; high-sensitivity C-reactive protein by 26%, tumor necrosis factor-α by 19.8%, plasminogen activator inhibitor type 1 by 16.8%, and interleukin-6/interleukin-10 ratio by 24%. In addition, the resveratrol supplement increased anti-inflammatoryinterleukin-10 by 19.8%. A marker of fibrinolytic (clotting) activity, soluble intercellular adhesion molecule, was also decrease in the resveratrol group by 5.7%.
The results of the present study show that a 1-year consumption of a resveratrol-rich supplement improved the inflammatory and fibrinolytic status in patients who were on statins for primary prevention of CVD. Thus, dietary intervention with resveratrol could complement the current standard therapy in the primary prevention of CVD.
http://www.ncbi.nlm.nih.gov/pubmed/22520621
