29/12/2025
overview of Radiotherapy:
1. Definition
Radiotherapy (or radiation therapy) is a medical treatment that uses high-energy radiation to kill cancer cells or shrink tumors. It can also be used to relieve symptoms in certain non-cancerous conditions.
2. Principle
Radiation damages the DNA of cells.
Cancer cells are less able to repair DNA damage compared to normal cells.
This leads to cell death or loss of ability to divide, reducing the tumor size.
3. Types of Radiotherapy
A. Based on Delivery
External Beam Radiotherapy (EBRT / Teletherapy):
Radiation is delivered from outside the body using a machine called linear accelerator (LINAC).
Common techniques:
3D Conformal Radiotherapy (3D-CRT)
Intensity-Modulated Radiotherapy (IMRT)
Stereotactic Radiosurgery (SRS) / Stereotactic Body Radiotherapy (SBRT)
Internal Radiotherapy (Brachytherapy):
Radioactive sources are placed inside or near the tumor.
Example:
Intracavitary (e.g., cervical cancer)
Interstitial (e.g., prostate seeds)
B. Based on Purpose
Curative: To cure cancer completely.
Adjuvant: After surgery to kill remaining cancer cells.
Neoadjuvant: Before surgery to shrink tumors.
Palliative: To relieve symptoms like pain, bleeding, or obstruction.
4. Mechanism of Action
Radiation ionizes atoms in cells → produces free radicals.
Free radicals damage DNA strands.
Cancer cells die or cannot divide → tumor shrinks.
5. Side Effects
Acute: Fatigue, skin redness, hair loss at treatment site, nausea (depending on area).
Chronic: Fibrosis, secondary cancers, organ-specific damage (lung, heart, kidney, etc.).
6. Advantages
Non-invasive (for EBRT).
Can target tumors precisely with modern techniques.
Can be combined with chemotherapy or surgery for better outcomes.
7. Example Uses
Breast cancer, lung cancer, prostate cancer, brain tumors.
Leukemia rarely (mostly total body irradiation before bone marrow transplant).
Palliation in advanced cancers (bone metastases, spinal cord compression).