
23/07/2025
Difference between Diclofenac Potassium and Diclofenac Sodium
Diclofenac potassium and diclofenac sodium are two different salt forms of the nonsteroidal anti-inflammatory drug (NSAID) diclofenac. While they share similar properties and uses, there are some key differences:
1. Salt Form
- *Diclofenac Potassium*: Contains potassium as the counterion.
- *Diclofenac Sodium*: Contains sodium as the counterion.
2. Absorption Rate
- *Diclofenac Potassium*: Generally considered to have a faster absorption rate compared to diclofenac sodium.
- *Diclofenac Sodium*: Has a slower absorption rate, which may lead to a more gradual onset of action.
3. Bioavailability
- *Diclofenac Potassium*: Typically has a higher bioavailability (around 50-60%) compared to diclofenac sodium.
- *Diclofenac Sodium*: Has a lower bioavailability (around 30-50%).
4. Therapeutic Effects
- *Diclofenac Potassium*: Often preferred for acute pain management due to its faster onset of action.
- *Diclofenac Sodium*: May be more suitable for chronic pain management due to its longer duration of action.
5. Side Effects
- *Diclofenac Potassium*: May have a higher incidence of gastrointestinal side effects due to its faster absorption rate.
- *Diclofenac Sodium*: May have a lower risk of gastrointestinal side effects, but may cause more sodium-related issues in sensitive individuals.