02/01/2026
https://youtube.com/shorts/z2ZQ5i16LIo?si=4yD6sljXh6FoulCx
🩺 End-stage lymphostatic fibromatosis 📈
complicating chronic congenital lymphedema.
Pathophysiology:
persistent high-protein lymphostasis → macrophage recruitment 🧟♂️ → TGF-β surge 📡 → fibroblast activation 🏭 → pathologic collagen I/III deposition 🧱 → brawny, indurated, nodular extremity.
Clinical:
30-yr ♀️, 15-yr unilateral LL swelling → non-pitting, woody consistency 🪵, peau d’orange 🍊, recurrent cellulitis 🔥.
Imaging:
MRI 📸—cutaneous thickening great than 1 cm, honey-comb trabeculae 🍯, no neoplasia.
Rx:
radical en-bloc resection ✂️ + STSG 🩹; aim: restore contour, slash infection nidus.
Pearl:
early decongestive therapy 💆♀️ + infection prophylaxis 💊 = best defense against irreversible fibrosis 🪨.
🩺 End-stage lymphostatic fibromatosis 📈 complicating chronic congenital lymphedema.Pathophysiology: persistent high-protein lymphostasis → macrophage recru...