18/06/2023
Fibromyalgia Syndrome
is a disease characterized by chronic pain, stiffness, and tenderness of muscles, tendons, and joints, without detectable inflammation. Fibromyalgia does not cause body damage or deformity. Fatigue affects 90 percent of patients and sleep disorders are common. Fibromyalgia can be associated with other rheumatic conditions, and irritable bowel syndrome (IBS). There is no definitive medical test for the diagnosis of fibromyalgia and fibromyalgia symptoms can come and go over time. Diagnosis is made by eliminating other possible causes of the symptoms. It can take time to tease out which symptom is caused by what problem[1]. FMS is NOT just one condition; it's a complex syndrome involving many different factors that can severely impact and disrupt a person’s daily life.
Fibromyalgia Syndrome (FMS) is considered as a systemic problem involving biochemical, neuroendocrine, and physiologic abnormalities, leading to a disorder of pain processing and perception (i.e. allodynia, hyperalgesia). The symptoms associated with FMS may originate from primary or secondary/reactive causes. [2]
The most effective treatment is a combination of education, stress reduction, exercise, and medication.
Prevalence
FMS occurs in more than 6 million Americans, or 4% of the population, causing it to be the most common musculoskeletal disorder in the U.S. It affects mainly women (90%) more often than men. Symptoms typically present between the ages of 20-55 years, but individuals have been diagnosed as young as 6 years and as old as 85 years of age.
Pathophysiology
The pathogenesis of FMS is theorized to be a malfunctioning of the central nervous system (CNS), characterized by central sensitization, which is a heightened pain perception accompanied by ineffective pain inhibition and/or modulation. This increased response to peripheral stimuli causes hyperalgesia, allodynia, and referred pain across multiple spinal segments, resulting in chronic widespread pain and decreased tolerance to sensory input of the musculoskeletal system.
FMS systemically causes a dysregulation : : neurologic; immunologic; endocrinologic; and enteric organ systems
1. Autonomic Nervous System
The Autonomic Nervous System (ANS) is responsible for regulating the Sympathetic (“fight or flight”) and the Parasympathetic (“rest and digest”) responses. With FMS, patients experience a systemically heightened sympathetic (SNS) response with a diminished parasympathetic (PNS) modulation. Continuous over activation of the SNS results in increased heart rate, excessive gastric secretions and contractions, abnormalities of smooth muscle contraction throughout the digestive tract, rapid and shallow respiration, and vasoconstriction. This can lead to malnutrition due to absorption and digestion disruptions. Prolonged inhibition of PNS alters the neuroimmunoendocrine systems, directly affecting growth hormone secretion by the pituitary gland. This can result in nonrestorative sleep, pain, fatigue, and cognitive/mood symptoms.
2. Immune System
The immune response to infection, inflammation, and/or trauma is a release of cytokines for local healing, which trigger the CNS to release glial cells within the brain and spinal cord for healing support and pain response. With FMS, this auto-immune response is heightened, causing an excess of glia in the body which creates an exaggerated state of pain (chronic)
Causes
There are many hypotheses of how multiple factors play a role in the development of FMS. The exact etiology of FMS is still being researched; however, there are several potential causes and risk factors, listed below, that are currently associated with, or increase one’s risk for developing this condition.
Viral
Occupation, seasonal, environmental influences
Adverse childhood experiences (i.e. PTSD)
Psychological and cognitive/behavioral factors
Other conditions: RA, systemic lupus erythematosus, or AS
Current research remains inconclusive regarding the genetic or hereditary cause of SMS. A family history of FMS is a risk factor.
Muscle pain is characterized as the major symptom of FMS, often described by patients as “aching or burning” regardless of physical activity. Other symptoms or associated problems occur, with various reports of frequencies, that can also affect function. FMS may cause residual pain sensations at a lower intensity due to repetitive exposure to peripheral stimuli or activity, also known as the “Wind-up Response.”[3][2]Other symptoms include sleep disturbances, fatigue, and other cognitive and somatic symptoms. [4]
Symptoms are often exacerbated by:
Stress
Overloading physical activity
Overstretching
Damp or chilly weather
Heat exposure of humidity
Sudden change in barometric pressure
Trauma
Another illness
A recent study carried out by Sempere-Rubio et al found out that functional capacity, upper limb muscular strength, postural maintenance, pain threshold, and anxiety are important predictive factors of QoL in women with FM.
Aerobic and Resistance Exercise
According to the Ottawa Panel evidence-based clinical practice guidelines (2008), supervised light aerobic exercise and strength/resistance training is highly recommended for the management of patients with chronic pain, like those with FMS. It has been found to increase their capacity for activity while minimizing their symptoms associated with FMS. Specifically, aerobic activity has been shown to improve psychological symptoms associated with depression, cognitive decline, and sleep disturbances. Exercise also improves patient’s cellular metabolism and respiratory capacity, increases lean muscle mass and tone, and increases oxygen uptake within the body’s system(s), which ultimately minimizes their complaints of chronic pain and fatigue.[2][9]
Manual / Passive Therapy
Some studies support that TENS and joint mobilizations foster the reduction of pain as short-term relief in patients with FMS. Specifically, patients with chronic back pain due to FMS may benefit from spinal manipulations with limited evidence to support this modality. Moderate evidence shows that the use of passive STM is helpful with pain regulation. In addition, diffuse chronic pain presentations are less likely to be reliable for medical management with TENS compared to localized pain. Passive therapy should not be the foundation of FMS medical management due to the maladaptive illness beliefs and coping strategies for patients’ pain.
Manual lymph drainage therapy and connective tissue massage have also been studied in women with fibromyalgia. Researchers used the Fibromyalgia Impact Questionnaire and the Nottingham Health Profile to measure the impact of the treatment. Their research suggests that both manual lymph drainage therapy and connective tissue massage show improvements in both the FIQ and the Nottingham Health Profile. However, there were significantly greater improvements in the group that received manual lymph drainage therapy, suggesting that manual lymphatic drainage therapy may be preferred over connective tissue.